ICU入室患者におけるinterleukin-1関連遺伝子多型のIL-1ra/IL-1β不均衡を介した予後への影響
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| Published in | 日本集中治療医学会雑誌 Vol. 14; no. 1; pp. 81 - 84 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本集中治療医学会
01.01.2007
|
| Online Access | Get full text |
| ISSN | 1340-7988 1882-966X |
| DOI | 10.3918/jsicm.14.81 |
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| Author | 織田, 成人 中田, 孝明 平澤, 博之 渡邉, 栄三 大谷, 俊介 仲村, 将高 鈴木, 理紗 安部, 隆三 |
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| Author_xml | – sequence: 1 fullname: 中田, 孝明 organization: 千葉大学大学院医学研究院救急集中治療医学 – sequence: 1 fullname: 大谷, 俊介 organization: 千葉大学大学院医学研究院救急集中治療医学 – sequence: 1 fullname: 平澤, 博之 organization: 千葉大学大学院医学研究院救急集中治療医学 – sequence: 1 fullname: 仲村, 将高 organization: 千葉大学大学院医学研究院救急集中治療医学 – sequence: 1 fullname: 鈴木, 理紗 organization: 千葉大学医学部 – sequence: 1 fullname: 渡邉, 栄三 organization: 千葉大学大学院医学研究院救急集中治療医学 – sequence: 1 fullname: 安部, 隆三 organization: 千葉大学大学院医学研究院救急集中治療医学 – sequence: 1 fullname: 織田, 成人 organization: 千葉大学大学院医学研究院救急集中治療医学 |
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| References | 1) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-74. 13) Watanabe E, Hirasawa H, Oda S, et al. Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms. Crit Care Med. 2005;33:89-97. 4) 渡邉栄三, 平澤博之, 織田成人, 他. Cytokine産生に関する遺伝子多型. ICUとCCU. 2003;27:3-10. 14) Watanabe E, Hirasawa H, Oda S, et al. Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications. J Trauma. 2005;59:1181-90. 2) 志賀英敏, 平澤博之, 織田成人, 他. SIRS/CARS. ICUとCCU. 2002;26:503-9. 5) Gebhard F, Pfetsch H, Steinbach G, et al. Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg. 2000;135:291-5. 3) 中村祐輔. SNPの医学的意義. 中村祐輔編. SNP遺伝子多型の戦略. 東京 : 中山書店 ; 2000. p. 2-17. 8) 相川直樹. ショックと臓器障害の病態におけるサイトカインの役割. 日救急医会誌. 1994;5:641-54. 16) Vamvakopoulos J, Green C, Metcalfe S. Genetic control of IL-1β bioactivity through differential regulation of the IL-1 receptor antagonist. Eur J Immunol. 2002;32:2988-96. 9) 松田兼一, 平澤博之, 織田成人, 他. Cytokine血中濃度迅速測定. 救急医学. 2001;25:847-53. 12) Vincent JL, De Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med. 1998;26:1793-800. 19) Wen AQ, Wang J, Feng K, et al. Effects of haplotypes in the interleukin 1β promoter on lipopolysaccharide-induced interleukin 1β expression. Shock. 2006;26:25-30. 6) Oda S, Hirasawa H, Shiga H, et al. Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS) /sepsis. Cytokine. 2005;29:169-75. 18) 井ノ上逸朗. 遺伝子多型を利用した疾患遺伝子検索法. 中村祐輔編. SNP遺伝子多型の戦略. 東京 : 中山書店 ; 2000, p. 47-70. 11) Hurme M, Santtila S. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes. Eur J Immunol. 1998;28:2598-602. 15) Tountas NA, Casini-Raggi V, Yang H, et al. Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. Gastroenterology. 1999;117:806-13. 10) Santtila S, Savinainen K, Hurme M. Presence of the IL-1RA allele*2 (IL-1RN*2) is associated with enhanced IL-1β production in vitro. Scand J Immunol. 1998;47:195-8. 7) Van Zee KJ, DeForge LE, Fischer E, et al. IL-8 in septic shock, endotoxemia, and after IL-1 administration. J Immunol. 1991;146:3478-82. 17) Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323-40. |
| References_xml | – reference: 5) Gebhard F, Pfetsch H, Steinbach G, et al. Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg. 2000;135:291-5. – reference: 9) 松田兼一, 平澤博之, 織田成人, 他. Cytokine血中濃度迅速測定. 救急医学. 2001;25:847-53. – reference: 13) Watanabe E, Hirasawa H, Oda S, et al. Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms. Crit Care Med. 2005;33:89-97. – reference: 19) Wen AQ, Wang J, Feng K, et al. Effects of haplotypes in the interleukin 1β promoter on lipopolysaccharide-induced interleukin 1β expression. Shock. 2006;26:25-30. – reference: 4) 渡邉栄三, 平澤博之, 織田成人, 他. Cytokine産生に関する遺伝子多型. ICUとCCU. 2003;27:3-10. – reference: 8) 相川直樹. ショックと臓器障害の病態におけるサイトカインの役割. 日救急医会誌. 1994;5:641-54. – reference: 6) Oda S, Hirasawa H, Shiga H, et al. Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS) /sepsis. Cytokine. 2005;29:169-75. – reference: 11) Hurme M, Santtila S. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes. Eur J Immunol. 1998;28:2598-602. – reference: 7) Van Zee KJ, DeForge LE, Fischer E, et al. IL-8 in septic shock, endotoxemia, and after IL-1 administration. J Immunol. 1991;146:3478-82. – reference: 2) 志賀英敏, 平澤博之, 織田成人, 他. SIRS/CARS. ICUとCCU. 2002;26:503-9. – reference: 14) Watanabe E, Hirasawa H, Oda S, et al. Cytokine-related genotypic differences in peak interleukin-6 blood levels of patients with SIRS and septic complications. J Trauma. 2005;59:1181-90. – reference: 17) Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323-40. – reference: 1) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-74. – reference: 3) 中村祐輔. SNPの医学的意義. 中村祐輔編. SNP遺伝子多型の戦略. 東京 : 中山書店 ; 2000. p. 2-17. – reference: 15) Tountas NA, Casini-Raggi V, Yang H, et al. Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. Gastroenterology. 1999;117:806-13. – reference: 10) Santtila S, Savinainen K, Hurme M. Presence of the IL-1RA allele*2 (IL-1RN*2) is associated with enhanced IL-1β production in vitro. Scand J Immunol. 1998;47:195-8. – reference: 16) Vamvakopoulos J, Green C, Metcalfe S. Genetic control of IL-1β bioactivity through differential regulation of the IL-1 receptor antagonist. Eur J Immunol. 2002;32:2988-96. – reference: 12) Vincent JL, De Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med. 1998;26:1793-800. – reference: 18) 井ノ上逸朗. 遺伝子多型を利用した疾患遺伝子検索法. 中村祐輔編. SNP遺伝子多型の戦略. 東京 : 中山書店 ; 2000, p. 47-70. |
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| Title | ICU入室患者におけるinterleukin-1関連遺伝子多型のIL-1ra/IL-1β不均衡を介した予後への影響 |
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