Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients

• Published in: Alzheimer's & dementia Vol. 16; no. 11; pp. 1504 - 1514
• Main Authors: Finsterwalder, Sofia, Vlegels, Naomi, Gesierich, Benno, Araque Caballero, Miguel Á., Weaver, Nick A., Franzmeier, Nicolai, Georgakis, Marios K., Konieczny, Marek J., Koek, Huiberdina L., Karch, Celeste M., Graff‐Radford, Neill R., Salloway, Stephen, Oh, Hwamee, Allegri, Ricardo F., Chhatwal, Jasmeer P., Jessen, Frank, Düzel, Emrah, Dobisch, Laura, Metzger, Coraline, Peters, Oliver, Incesoy, Enise I., Priller, Josef, Spruth, Eike J., Schneider, Anja, Fließbach, Klaus, Buerger, Katharina, Janowitz, Daniel, Teipel, Stefan J., Kilimann, Ingo, Laske, Christoph, Buchmann, Martina, Heneka, Michael T., Brosseron, Frederic, Spottke, Annika, Roy, Nina, Ertl‐Wagner, Birgit, Scheffler, Klaus, Seo, Sang Won, Kim, Yeshin, Na, Duk L., Kim, Hee Jin, Jang, Hyemin, Ewers, Michael, Levin, Johannes, Schmidt, Reinhold, Pasternak, Ofer, Dichgans, Martin, Biessels, Geert Jan, Duering, Marco
• Format: Journal Article
• Language: English
• Published: United States 01.11.2020
• Subjects: Adult; Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer's disease; biomarker; Brain - diagnostic imaging; Brain - pathology; cerebral small vessel disease; Cerebral Small Vessel Diseases - diagnostic imaging; Cerebral Small Vessel Diseases - pathology; Diffusion Magnetic Resonance Imaging; diffusion tensor imaging; Female; free water imaging; Humans; Male; Middle Aged; white matter; white matter; cerebral small vessel disease; diffusion tensor imaging; free water imaging; biomarker; Alzheimer's disease

Introduction Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. Methods We studied six samples (N = 365 p...