Potential role of group X secretory phospholipase A2 in cyclooxygenase‐2‐dependent PGE2 formation during colon tumorigenesis

• Published in: FEBS letters Vol. 487; no. 2; pp. 262 - 266
• Main Authors: Morioka, Yasuhide, Ikeda, Minoru, Saiga, Akihiko, Fujii, Noriko, Ishimoto, Yoshikazu, Arita, Hitoshi, Hanasaki, Kohji
• Format: Journal Article
• Language: English
• Published: 29.12.2000
• Subjects: BSA, bovine serum albumin; Colon tumor; COX, cyclooxygenase; cPLA2, cytosolic PLA2; Cyclooxygenase; Cytosolic phospholipase A2; FAP, familial adenomatous polyposis; NSAIDs, non-steroidal anti-inflammatory drugs; PBS, phosphate-buffered saline; PG, prostaglandin; Phospholipase A2; PLA2, phospholipase A2; PPARδ, peroxisome proliferator-activated receptor δ; Prostaglandin; Secretory phospholipase A2; sPLA2, secretory PLA2; sPLA2-IB, group IB sPLA2; sPLA2-IIA, group IIA sPLA2; sPLA2-X, group X sPLA2

Although the cyclooxygenase‐2 (COX‐2) pathway of the arachidonic acid cascade has been suggested to play an important role in colon carcinogenesis, there is little information concerning the identity of phospholipase A2 (PLA2) involved in the arachidonic acid release in colon tumors. Here, we compar...