TDMの落とし穴 偽陽性と偽陰性
「緒言」Therapeutic drug monitoring (TDM)は, 血中薬物濃度の治療域が狭い薬物の適正使用を実践するうえで必要不可欠なツールの1つである. 現在, TDMの基盤をなす薬物の血中濃度測定には, 一部の薬物を除き免疫学的測定法が汎用されている. 免疫学的測定法には, 酵素免疫測定法(enzyme-linked immunosorbent assay: ELISA), 蛍光偏光免疫測定法(fluorescence polarization immunoassay: FPIA), 均一酵素免疫測定法(enzyme multiplied immunoassay techni...
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| Published in | 医療薬学 Vol. 41; no. 4; pp. 215 - 222 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
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一般社団法人日本医療薬学会
10.04.2015
日本医療薬学会 |
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| Abstract | 「緒言」Therapeutic drug monitoring (TDM)は, 血中薬物濃度の治療域が狭い薬物の適正使用を実践するうえで必要不可欠なツールの1つである. 現在, TDMの基盤をなす薬物の血中濃度測定には, 一部の薬物を除き免疫学的測定法が汎用されている. 免疫学的測定法には, 酵素免疫測定法(enzyme-linked immunosorbent assay: ELISA), 蛍光偏光免疫測定法(fluorescence polarization immunoassay: FPIA), 均一酵素免疫測定法(enzyme multiplied immunoassay technique: EMITなど), 競合蛍光免疫測定法(competitive fluorescence immunoassay: CFIA), 化学発光免疫測定法(chemiluminescent immunoassay: CLIA), 電気化学発光免疫測定法(electro chemiluminescent immunoassay: ECLIA), 微粒子免疫測定法(microparticle enzyme multiplied immunoassay: MEIA), イムノクロマト法(affinity column-mediated immunoassay: ACMIA), ラテックス免疫凝集阻害法(particle-enhanced turbidimetric inhibition immunoassay: PETINIA, kinetic interaction of microparticles in a solution: KIMS)など様々なタイプのものが開発されている. |
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| AbstractList | 「緒言」Therapeutic drug monitoring (TDM)は, 血中薬物濃度の治療域が狭い薬物の適正使用を実践するうえで必要不可欠なツールの1つである. 現在, TDMの基盤をなす薬物の血中濃度測定には, 一部の薬物を除き免疫学的測定法が汎用されている. 免疫学的測定法には, 酵素免疫測定法(enzyme-linked immunosorbent assay: ELISA), 蛍光偏光免疫測定法(fluorescence polarization immunoassay: FPIA), 均一酵素免疫測定法(enzyme multiplied immunoassay technique: EMITなど), 競合蛍光免疫測定法(competitive fluorescence immunoassay: CFIA), 化学発光免疫測定法(chemiluminescent immunoassay: CLIA), 電気化学発光免疫測定法(electro chemiluminescent immunoassay: ECLIA), 微粒子免疫測定法(microparticle enzyme multiplied immunoassay: MEIA), イムノクロマト法(affinity column-mediated immunoassay: ACMIA), ラテックス免疫凝集阻害法(particle-enhanced turbidimetric inhibition immunoassay: PETINIA, kinetic interaction of microparticles in a solution: KIMS)など様々なタイプのものが開発されている. |
| Author | 丸山, 徹 猿渡, 淳二 平田, 憲史郎 田口, 和明 |
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| DOI | 10.5649/jjphcs.41.215 |
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| Subtitle | 偽陽性と偽陰性 |
| Title | TDMの落とし穴 |
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