RU 28965 IN THE DERMATOLOGICAL FIELD
We used RU 28965, a new macrolide antibiotic, in the treatment of bacterial skin infections, and studied its efficacy. The subjects' diseases were folliculitis (5), furuncle (3), carbuncle (2), erysipelas (1), complicated phlegmon and superficial lymphangitis (1), subcutaneous abscess (1), infe...
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| Published in | CHEMOTHERAPY Vol. 36; no. Supplement4; pp. 568 - 573 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1988
公益社団法人 日本化学療法学会 |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.36.Supplement4_568 |
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| Abstract | We used RU 28965, a new macrolide antibiotic, in the treatment of bacterial skin infections, and studied its efficacy. The subjects' diseases were folliculitis (5), furuncle (3), carbuncle (2), erysipelas (1), complicated phlegmon and superficial lymphangitis (1), subcutaneous abscess (1), infectious atheroma (2), acne conglobata (2) and secondary infection (3), a total of 20 cases. Administration was discontinued in two cases because of adverse effects. Clinical efficacy in the remaining 18 cases was: cure 12, marked improvement 3, and one case each of moderate improvement, slight improvement and no change. Thus the efficacy rate (moderate improvement or better) was 88.9%. Bacteria isolated from the lesions were S. aureus (6 strains), coagulase-negative Staphylococcus sp.(5) and B. subtilis (1). The overall bacterial elimination rate was 100%. Abnormal laboratory test values were 2 cases of COOMBS' test becoming positive, 2 cases of a decrease in hemoglobin and 1 case of a decrease in hematocrit. As adverse effects, digestive organ symptoms such as nausea, vomiting, etc., occurred in 2 patients. The utility rate (useful or better), calculated on the basis of overall evaluation of the above results, was 83.3%. |
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| AbstractList | We used RU 28965, a new macrolide antibiotic, in the treatment of bacterial skin infections, and studied its efficacy. The subjects' diseases were folliculitis (5), furuncle (3), carbuncle (2), erysipelas (1), complicated phlegmon and superficial lymphangitis (1), subcutaneous abscess (1), infectious atheroma (2), acne conglobata (2) and secondary infection (3), a total of 20 cases. Administration was discontinued in two cases because of adverse effects. Clinical efficacy in the remaining 18 cases was: cure 12, marked improvement 3, and one case each of moderate improvement, slight improvement and no change. Thus the efficacy rate (moderate improvement or better) was 88.9%. Bacteria isolated from the lesions were S. aureus (6 strains), coagulase-negative Staphylococcus sp.(5) and B. subtilis (1). The overall bacterial elimination rate was 100%. Abnormal laboratory test values were 2 cases of COOMBS' test becoming positive, 2 cases of a decrease in hemoglobin and 1 case of a decrease in hematocrit. As adverse effects, digestive organ symptoms such as nausea, vomiting, etc., occurred in 2 patients.The utility rate (useful or better), calculated on the basis of overall evaluation of the above results, was 83.3%.
新しい経口マクロライド系抗生剤RU28965を皮膚科領域の細菌感染症に使用し, その効果を検討した。対象疾患は毛嚢炎5例, 痢3例, 痢2例, 丹毒1例, 蜂巣炎と表在性リンパ管炎の併発1例, 皮下膿瘍1例, 感染性粉瘤2例, 集簇性痢瘡2例, 二次感染3例の20例であった。副作用のため途中で投与を中止した2例を除く18例に対する臨床効果は, 治癒12例, 著しく改善3例, かなり改善, やや改善, 不変各々1例であり, 有効率は88, 9%(かなり改善以上) であった。病巣より分離された菌はS.aures6株, Coagulase negativeのStaphylococcussp.5株, B.subtilis1株であり, 全体の消失率は100%であった。臨床検査値異常はクームス陽性化, ヘモグロビン低下各々2例, ヘマトクリット値低下1例が認められ, また, 副作用は嘔気・嘔吐等の消化器症状が2例に認められた。以上の結果を総合した有用率は83.3%(有用以上) であった。 We used RU 28965, a new macrolide antibiotic, in the treatment of bacterial skin infections, and studied its efficacy. The subjects' diseases were folliculitis (5), furuncle (3), carbuncle (2), erysipelas (1), complicated phlegmon and superficial lymphangitis (1), subcutaneous abscess (1), infectious atheroma (2), acne conglobata (2) and secondary infection (3), a total of 20 cases. Administration was discontinued in two cases because of adverse effects. Clinical efficacy in the remaining 18 cases was: cure 12, marked improvement 3, and one case each of moderate improvement, slight improvement and no change. Thus the efficacy rate (moderate improvement or better) was 88.9%. Bacteria isolated from the lesions were S. aureus (6 strains), coagulase-negative Staphylococcus sp.(5) and B. subtilis (1). The overall bacterial elimination rate was 100%. Abnormal laboratory test values were 2 cases of COOMBS' test becoming positive, 2 cases of a decrease in hemoglobin and 1 case of a decrease in hematocrit. As adverse effects, digestive organ symptoms such as nausea, vomiting, etc., occurred in 2 patients. The utility rate (useful or better), calculated on the basis of overall evaluation of the above results, was 83.3%. |
| Author | TAKAHASHI, OSAMU TAKEDA, KATSUYUKI |
| Author_FL | 武田 克之 高橋 収 |
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| References | 1) 荒田次郎, 他: 皮膚ブドウ球菌感染症, 日皮会誌96, 1458, 1986 2) 第35回日本化学療法学会総会, 新薬シンポジウムIV. RU 28965, 盛岡, 1987 |
| References_xml | – reference: 2) 第35回日本化学療法学会総会, 新薬シンポジウムIV. RU 28965, 盛岡, 1987 – reference: 1) 荒田次郎, 他: 皮膚ブドウ球菌感染症, 日皮会誌96, 1458, 1986 |
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| Title | RU 28965 IN THE DERMATOLOGICAL FIELD |
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