A CASE OF TUBERCULOUS ANEURYSM OF SUBCLAVIAN ARTERY OCCURRED IN THE COURSE OF TREATMENT FOR MILIARY TUBERCULOSIS

This case is a 56-year old woman. Steroids were being administered perorally after a thymectomy for myasthenia gravis. A fever of 38-39 degrees Celsius appeared during night, an abnormal shadow showed up on a chest X-ray and the patient was hospitalized. Gaffky No.2 acid-fast bacilli were detected i...

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Published inKekkaku Vol. 82; no. 2; pp. 111 - 114
Main Authors KUDOH, Shouji, SAKAKIBARA, Keitaro, OKANO, Tetsuya, KURANE, Shuji
Format Journal Article
LanguageJapanese
Published Japan JAPANESE SOCIETY FOR TUBERCULOSIS 01.02.2007
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ISSN0022-9776
1884-2410
DOI10.11400/kekkaku1923.82.111

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Abstract This case is a 56-year old woman. Steroids were being administered perorally after a thymectomy for myasthenia gravis. A fever of 38-39 degrees Celsius appeared during night, an abnormal shadow showed up on a chest X-ray and the patient was hospitalized. Gaffky No.2 acid-fast bacilli were detected in the patient's sputum and the chest CT showed diffuse granular-like shadow, the patient was diagnosed as miliary tuberculosis and treatment with combined use of INH, RFP, EB, and PZA was started. Subsequently, fever started to subside and the miliary shadow on chest X-ray improved, however, six weeks after the start of treatment, hoarseness and dysphagia appeared. From the cervical CT and cervical angiography findings, the diagnosis of right subclavian artery impending ruptured aneurysm was made. Because the patient's sputum was acid-fast bacilli positive and because the patient had undergone thymectomy, it was decided that it would be difficult to treat her by a thoracotomy again. Therefore, a right subclavian artery stent insertion, right subclavian artery?right common carotid artery bypass creation operation was carried out with the objective of blocking the flow of blood to the aneurysm. The hoarseness and dysphagia improved post-operatively and the patient's progress is being monitored. Tuberculous aneurysms are a rare affection and they are mostly discovered when the autopsy is done, however, this case was diagnosed due to the manifestation of subjective symptoms. While this case was not diagnosed histopathologically, it is envisaged from the clinical progress that this was a tuberculous subclavian aneurysm complicated during the treatment for miliary tuberculosis.
AbstractList This case is a 56-year old woman. Steroids were being administered perorally after a thymectomy for myasthenia gravis. A fever of 38-39 degrees Celsius appeared during night, an abnormal shadow showed up on a chest X-ray and the patient was hospitalized. Gaffky No.2 acid-fast bacilli were detected in the patient's sputum and the chest CT showed diffuse granular-like shadow, the patient was diagnosed as miliary tuberculosis and treatment with combined use of INH, RFP, EB, and PZA was started. Subsequently, fever started to subside and the miliary shadow on chest X-ray improved, however, six weeks after the start of treatment, hoarseness and dysphagia appeared. From the cervical CT and cervical angiography findings, the diagnosis of right subclavian artery impending ruptured aneurysm was made. Because the patient's sputum was acid-fast bacilli positive and because the patient had undergone thymectomy, it was decided that it would be difficult to treat her by a thoracotomy again. Therefore, a right subclavian artery stent insertion, right subclavian artery?right common carotid artery bypass creation operation was carried out with the objective of blocking the flow of blood to the aneurysm. The hoarseness and dysphagia improved post-operatively and the patient's progress is being monitored. Tuberculous aneurysms are a rare affection and they are mostly discovered when the autopsy is done, however, this case was diagnosed due to the manifestation of subjective symptoms. While this case was not diagnosed histopathologically, it is envisaged from the clinical progress that this was a tuberculous subclavian aneurysm complicated during the treatment for miliary tuberculosis.
This case is a 56-year old woman. Steroids were being administered perorally after a thymectomy for myasthenia gravis. A fever of 38-39 degrees Celsius appeared during night, an abnormal shadow showed up on a chest X-ray and the patient was hospitalized. Gaffky No. 2 acid-fast bacilli were detected in the patient's sputum and the chest CT showed diffuse granular-like shadow, the patient was diagnosed as miliary tuberculosis and treatment with combined use of INH, RFP, EB, and PZA was started. Subsequently, fever started to subside and the miliary shadow on chest X-ray improved, however, six weeks after the start of treatment, hoarseness and dysphagia appeared. From the cervical CT and cervical angiography findings, the diagnosis of right subclavian artery impending ruptured aneurysm was made. Because the patient's sputum was acid-fast bacilli positive and because the patient had undergone thymectomy, it was decided that it would be difficult to treat her by a thoracotomy again. Therefore, a right subclavian artery stent insertion, right subclavian artery-right common carotid artery bypass creation operation was carried out with the objective of blocking the flow of blood to the aneurysm. The hoarseness and dysphagia improved post-operatively and the patient's progress is being monitored. Tuberculous aneurysms are a rare affection and they are mostly discovered when the autopsy is done, however, this case was diagnosed due to the manifestation of subjective symptoms. While this case was not diagnosed histopathologically, it is envisaged from the clinical progress that this was a tuberculous subclavian aneurysm complicated during the treatment for miliary tuberculosis.This case is a 56-year old woman. Steroids were being administered perorally after a thymectomy for myasthenia gravis. A fever of 38-39 degrees Celsius appeared during night, an abnormal shadow showed up on a chest X-ray and the patient was hospitalized. Gaffky No. 2 acid-fast bacilli were detected in the patient's sputum and the chest CT showed diffuse granular-like shadow, the patient was diagnosed as miliary tuberculosis and treatment with combined use of INH, RFP, EB, and PZA was started. Subsequently, fever started to subside and the miliary shadow on chest X-ray improved, however, six weeks after the start of treatment, hoarseness and dysphagia appeared. From the cervical CT and cervical angiography findings, the diagnosis of right subclavian artery impending ruptured aneurysm was made. Because the patient's sputum was acid-fast bacilli positive and because the patient had undergone thymectomy, it was decided that it would be difficult to treat her by a thoracotomy again. Therefore, a right subclavian artery stent insertion, right subclavian artery-right common carotid artery bypass creation operation was carried out with the objective of blocking the flow of blood to the aneurysm. The hoarseness and dysphagia improved post-operatively and the patient's progress is being monitored. Tuberculous aneurysms are a rare affection and they are mostly discovered when the autopsy is done, however, this case was diagnosed due to the manifestation of subjective symptoms. While this case was not diagnosed histopathologically, it is envisaged from the clinical progress that this was a tuberculous subclavian aneurysm complicated during the treatment for miliary tuberculosis.
Author KUDOH, Shouji
KURANE, Shuji
SAKAKIBARA, Keitaro
OKANO, Tetsuya
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  organization: Department of First Internal Medicine, Hakujikai Memorial Hospital
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  organization: Bunkyo Clinic
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References 3) Silbergleit A, Arbulu A, Defever BA, et al.: Tubelculous aortitis. Surgical resection of ruptured abdo m inal false aneurysm. J AMA. 1965; 193: 333-335.
2) Volini FI, Olfield RC, Thompson JR, et al.: Tuberculosis of the aorta. JAMA. 1962; 181: 78-83.
5) Richard L, Randolph G, Howard G, et al.: Tuberculous mycotic aneurysm of the aorta. C hest. 1999; 11 5: 522-531.
1) Parkhurst GF, Decker JP: Bacterial aortitis and mycotic aneurysm of the aorta. A report of the twelve case s. Am J Pathol. 1955; 31: 821-830.
4)須金紀雄, 高橋典明, 児浦利哉, 他: 結核性大動脈瘤の1例, 結核. 2000; 75: 589-593.
6) Lee TY, Lee TY, Cheng YF: Subclavian mycotic aneurysm presentinga s mediastinala bscess. Am J Emerg Med. 1998; 16: 714-716.
References_xml – reference: 2) Volini FI, Olfield RC, Thompson JR, et al.: Tuberculosis of the aorta. JAMA. 1962; 181: 78-83.
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– reference: 3) Silbergleit A, Arbulu A, Defever BA, et al.: Tubelculous aortitis. Surgical resection of ruptured abdo m inal false aneurysm. J AMA. 1965; 193: 333-335.
– reference: 4)須金紀雄, 高橋典明, 児浦利哉, 他: 結核性大動脈瘤の1例, 結核. 2000; 75: 589-593.
– reference: 6) Lee TY, Lee TY, Cheng YF: Subclavian mycotic aneurysm presentinga s mediastinala bscess. Am J Emerg Med. 1998; 16: 714-716.
– reference: 1) Parkhurst GF, Decker JP: Bacterial aortitis and mycotic aneurysm of the aorta. A report of the twelve case s. Am J Pathol. 1955; 31: 821-830.
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SubjectTerms Aneurysm, Infected - complications
Female
Humans
Middle Aged
Miliary tuberculosis
Myasthenia gravis
Steroid
Subclavian Artery
Tuberculosis - complications
Tuberculosis, Miliary - complications
Tuberculosis, Miliary - drug therapy
Tuberculous aneurysm
Title A CASE OF TUBERCULOUS ANEURYSM OF SUBCLAVIAN ARTERY OCCURRED IN THE COURSE OF TREATMENT FOR MILIARY TUBERCULOSIS
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Volume 82
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