Reovirus type-2–triggered autoimmune cholangitis in extrahepatic bile ducts of weanling DBA/1J mice

• Published in: Pediatric research Vol. 75; no. 1; pp. 29 - 37
• Main Authors: Nakashima, Tomomi, Hayashi, Toshiharu, Tomoeda, Saki, Yoshino, Midori, Mizuno, Takuya
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2014
• Subjects: 631/250/38; 692/699/1503/1328/1325; 692/699/255/2514; 692/700/1720; Alkaline Phosphatase - blood; Animals; Animals, Newborn; Autoantigens - blood; Autoimmune Diseases - virology; Bile Ducts, Extrahepatic - pathology; Bile Ducts, Extrahepatic - ultrastructure; Cholangitis - virology; Disease Models, Animal; Interferon-gamma - biosynthesis; Interferon-gamma - blood; Interferon-gamma - genetics; Interleukin-17 - genetics; Interleukin-4 - genetics; Liver - enzymology; Medicine & Public Health; Mice; Mice, Inbred DBA; Orthoreovirus, Mammalian - pathogenicity; Orthoreovirus, Mammalian - physiology; Pediatric Surgery; Pediatrics; RNA, Messenger - genetics; Transforming Growth Factor beta1 - biosynthesis; Transforming Growth Factor beta1 - blood; translational-investigation; Virus Replication

Background: Reovirus is a proposed cause of infantile biliary atresia. However, mechanistic insight regarding Reo-2 as a potential cholangiotropic virus is lacking. Furthermore, it is unknown whether Reo-2 infection can induce autoimmune-mediated bile duct injury. Methods: Lesions of bile ducts in n...