FUNDAMENTAL AND CLINICAL STUDIES ON TA-058 IN THE FIELD OF OBSTETRICS AND GYNECOLOGY
TA-058, a new injectable penicillin, was evaluated pharmacologically and clinically in the field of obstetrics and gynecology. In pharmacological studies, 1 g of TA-058 was intravenously administered to 7 cases prior to simple abdominal hysterectomy, and the concentrations of TA-058 after injection...
Saved in:
| Published in | CHEMOTHERAPY Vol. 32; no. Supplement2; pp. 732 - 736 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1984
公益社団法人 日本化学療法学会 |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.32.Supplement2_732 |
Cover
| Abstract | TA-058, a new injectable penicillin, was evaluated pharmacologically and clinically in the field of obstetrics and gynecology. In pharmacological studies, 1 g of TA-058 was intravenously administered to 7 cases prior to simple abdominal hysterectomy, and the concentrations of TA-058 after injection were determined in venous blood, arterial blood of uterus, uterine cervix, portio vaginalis, myometrium, endometrium, oviduct and ovary. The samples were collected during 37 min. to 187 min. after intravenous administration. The venous blood concentration of 4 cases ranged from 2.7μg/ml to 15.9μg/ml and die arterial blood concentration of 6 cases showed from 2.7μg/ml to 28.5 μg/ml. TA-058 was administered to 10 cases of various types of bacterial infections and clinical efficacy was excellent in 5 cases, good in 4 cases and failure in one cases. Overall cure rate was 90.0 %. No side effects nor adverse reactions on clinical laboratory findings in blood and hepatic and renal function were observed. |
|---|---|
| AbstractList | TA-058, a new injectable penicillin, was evaluated pharmacologically and clinically in the field of obstetrics and gynecology.In pharmacological studies, 1 g of TA-058 was intravenously administered to 7 cases prior to simple abdominal hysterectomy, and the concentrations of TA-058 after injection were determined in venous blood, arterial blood of uterus, uterine cervix, portio vaginalis, myometrium, endometrium, oviduct and ovary. The samples were collected during 37 min. to 187 min. after intravenous administration. The venous blood concentration of 4 cases ranged from 2.7μg/ml to 15.9μg/ml and die arterial blood concentration of 6 cases showed from 2.7μg/ml to 28.5 μg/ml.TA-058 was administered to 10 cases of various types of bacterial infections and clinical efficacy was excellent in 5 cases, good in 4 cases and failure in one cases. Overall cure rate was 90.0 %. No side effects nor adverse reactions on clinical laboratory findings in blood and hepatic and renal function were observed.
新しい合成ペニシリン剤TA-058の各種組織への移行性ならびに産婦人科領域感染症の臨床成績について検討した。腹式子宮全摘出術を施行した7例について1g静注投与した場合の肘静脈血, 子宮動脈血。子宮内膜, 子宮筋層, 子宮頸部, 子宮膣部, 卵管および卵巣への移行濃度を検討した。組織は静注後37min.から187min.にわたって採取した。肘静脈血中濃度は2.7μg/ml～15.9μg/ml, 子宮動脈血では2.7μg/ml～28.5μg/mlであった。臨床成績では, 産婦人科領域における感染症10例について検討した結果, 著効5例, 有効4例, 無効1例で有効率 (90%) であった。本剤投与によると思われる副作用は認められなかつた。 TA-058, a new injectable penicillin, was evaluated pharmacologically and clinically in the field of obstetrics and gynecology. In pharmacological studies, 1 g of TA-058 was intravenously administered to 7 cases prior to simple abdominal hysterectomy, and the concentrations of TA-058 after injection were determined in venous blood, arterial blood of uterus, uterine cervix, portio vaginalis, myometrium, endometrium, oviduct and ovary. The samples were collected during 37 min. to 187 min. after intravenous administration. The venous blood concentration of 4 cases ranged from 2.7μg/ml to 15.9μg/ml and die arterial blood concentration of 6 cases showed from 2.7μg/ml to 28.5 μg/ml. TA-058 was administered to 10 cases of various types of bacterial infections and clinical efficacy was excellent in 5 cases, good in 4 cases and failure in one cases. Overall cure rate was 90.0 %. No side effects nor adverse reactions on clinical laboratory findings in blood and hepatic and renal function were observed. |
| Author | SUGIYAMA, SHUSEI DOI, SOUNOSUKE MAEDA, YOICHI SUGIMOTO, OSAMU OHTSUKI, KATSUNORI TSUJII, KIYOSHIGE FUKUDA, YOSHIHIKO TSUBOKURA, SHOGO |
| Author_FL | 杉山 修成 前田 洋一 大槻 勝紀 土居 荘之介 杉本 修 福田 吉彦 坪倉 省吾 辻井 清重 |
| Author_FL_xml | – sequence: 1 fullname: 福田 吉彦 – sequence: 2 fullname: 坪倉 省吾 – sequence: 3 fullname: 大槻 勝紀 – sequence: 4 fullname: 前田 洋一 – sequence: 5 fullname: 杉山 修成 – sequence: 6 fullname: 土居 荘之介 – sequence: 7 fullname: 杉本 修 – sequence: 8 fullname: 辻井 清重 |
| Author_xml | – sequence: 1 fullname: SUGIYAMA, SHUSEI organization: Department of Obstetrics and Gynecology, Osaka Medical College – sequence: 1 fullname: DOI, SOUNOSUKE organization: Department of Obstetrics and Gynecology, Osaka Medical College – sequence: 1 fullname: SUGIMOTO, OSAMU organization: Department of Obstetrics and Gynecology, Osaka Medical College – sequence: 1 fullname: TSUJII, KIYOSHIGE organization: Department of Obstetrics and Gynecology, Hokusetsu Hospital – sequence: 1 fullname: FUKUDA, YOSHIHIKO organization: Department of Obstetrics and Gynecology, Osaka Medical College – sequence: 1 fullname: OHTSUKI, KATSUNORI organization: Department of Obstetrics and Gynecology, Osaka Medical College – sequence: 1 fullname: MAEDA, YOICHI organization: Department of Obstetrics and Gynecology, Osaka Medical College – sequence: 1 fullname: TSUBOKURA, SHOGO organization: Department of Obstetrics and Gynecology, Osaka Medical College |
| BackLink | https://cir.nii.ac.jp/crid/1390001206283850752$$DView record in CiNii |
| BookMark | eNpdUMtugzAQtKpUaprmH3zosaR-4GAfKY8EiYJUyCEn14DTECUUAT3k72uaHqJcdme1M6udeQST5rvRALxgtMCYMPRa7vXpe9jrTrVnLBhdULLIftr2qE-6GYh0KLkDU8y5bTEu7AmYIoSERfGSPYB539cFQhijJeFkCvJwk_jue5DkbgzdxIdeHCWRZ4Ys3_hRkME0gblrIcZhZNA6gGEUxD5MQ5i-ZXmQf0Re9qdcbZPAS-N0tX0C9zt17PX8v8_AJgxyb22Z5XjbOhCbDpYuRElZyeyq0oQI4VRIKfMqMS5FwYR2BKmWpcN31DjATrGzC8IV4SPEnNIZeL7cbepalvVYMRUjl4z2KGfIYcTQPi-0Qz-oLy3brj6p7ixVN9TlUcvbQCUl8jrQm9HkeyVVndQN_QWhCHZV |
| ContentType | Journal Article |
| Copyright | Japanese Society of Chemotherapy |
| Copyright_xml | – notice: Japanese Society of Chemotherapy |
| DBID | RYH |
| DOI | 10.11250/chemotherapy1953.32.Supplement2_732 |
| DatabaseName | CiNii Complete |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | TA-058の基礎的および臨床的効果の検討 |
| DocumentTitle_FL | TA-058の基礎的および臨床的効果の検討 |
| EISSN | 1884-5894 |
| EndPage | 736 |
| ExternalDocumentID | 130004072001 article_chemotherapy1953_32_Supplement2_32_Supplement2_732_article_char_en |
| GroupedDBID | 53G ADBBV ALMA_UNASSIGNED_HOLDINGS BAWUL DIK JSF JSH KQ8 RJT RZJ ZOHVM RYH |
| ID | FETCH-LOGICAL-j243t-eb9c35c54dde22997d0aa00922509b59e792d6c78f300017bf4b28a2817bf1833 |
| ISSN | 0009-3165 |
| IngestDate | Thu Jun 26 21:32:32 EDT 2025 Wed Sep 03 06:24:18 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | Supplement2 |
| Language | English Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j243t-eb9c35c54dde22997d0aa00922509b59e792d6c78f300017bf4b28a2817bf1833 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/chemotherapy1953/32/Supplement2/32_Supplement2_732/_article/-char/en |
| PageCount | 5 |
| ParticipantIDs | nii_cinii_1390001206283850752 jstage_primary_article_chemotherapy1953_32_Supplement2_32_Supplement2_732_article_char_en |
| PublicationCentury | 1900 |
| PublicationDate | 1984-00-00 |
| PublicationDateYYYYMMDD | 1984-01-01 |
| PublicationDate_xml | – year: 1984 text: 1984-00-00 |
| PublicationDecade | 1980 |
| PublicationTitle | CHEMOTHERAPY |
| PublicationTitleAlternate | Chemother. |
| PublicationTitle_FL | ＣＨＥＭＯＴＨＥＲＡＰＹ Chemother |
| PublicationYear | 1984 |
| Publisher | Japanese Society of Chemotherapy 公益社団法人 日本化学療法学会 |
| Publisher_xml | – name: Japanese Society of Chemotherapy – name: 公益社団法人 日本化学療法学会 |
| References | 2a) 高瀬善次郎, 他: 産婦人科領域におけるCefamandoleの基礎的・臨床的研究. Chemotherapy27 (S-5): 568-573, 1979 1) 第30回日本化学療法学会総会, 新薬シンポジウムIII, TA-058, 1982 (東京 b) 杉本修, 他: 産婦人科領域における6059-Sの使用経験. Chemotherapy 28 (S-7): 909-914, 1980 |
| References_xml | – reference: b) 杉本修, 他: 産婦人科領域における6059-Sの使用経験. Chemotherapy 28 (S-7): 909-914, 1980 – reference: 1) 第30回日本化学療法学会総会, 新薬シンポジウムIII, TA-058, 1982 (東京) – reference: 2a) 高瀬善次郎, 他: 産婦人科領域におけるCefamandoleの基礎的・臨床的研究. Chemotherapy27 (S-5): 568-573, 1979 |
| SSID | ssib001106282 ssj0000626693 ssib058492509 ssib005879733 ssib008506721 |
| Score | 1.1819932 |
| Snippet | TA-058, a new injectable penicillin, was evaluated pharmacologically and clinically in the field of obstetrics and gynecology. In pharmacological studies, 1 g... TA-058, a new injectable penicillin, was evaluated pharmacologically and clinically in the field of obstetrics and gynecology.In pharmacological studies, 1 g... |
| SourceID | nii jstage |
| SourceType | Publisher |
| StartPage | 732 |
| Title | FUNDAMENTAL AND CLINICAL STUDIES ON TA-058 IN THE FIELD OF OBSTETRICS AND GYNECOLOGY |
| URI | https://www.jstage.jst.go.jp/article/chemotherapy1953/32/Supplement2/32_Supplement2_732/_article/-char/en https://cir.nii.ac.jp/crid/1390001206283850752 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | CHEMOTHERAPY, 1984/04/25, Vol.32(Supplement2), pp.732-736 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELe6ISFeEAgQA4b8wFtJaZw_Th5DmzZp1xiWRFqfoiR1pVaiTFP7AF-VL8NdkibetIeB4MVK3JxT-y72-Xz3O0I-mLIcriTi23G90Mw8d-Gb0zEaTSJgFbetKjfgIrKD1JxdWVe93i_Fa-mwLwblz3vjSv6Gq1AHfMUo2T_gbNsoVMA18BdK4DCUD-LxJI3GHqLxIz5jNO6PLsKoxjeo9by-iPqJpw0tpx9GlXPPJPQvxujpIz7HiZ9chqO4opwuI3_UnSkdoQsCfyGA7NL70mq8cToNl2iXR7NpkMZ-a3Ydi7CqFGkk4nTuqxTQjMAfRewt0tZaEKezsKKZh0sRB-HU74wQuut05scZLOmYKrN1Mq2cSOS3Jnzsx62514UZv84MMZD1dOs4pmY5dZrj43zc2TsPGA9z3fjRM2Wa5c0zsrmz718MQL0DFpbK38FDw4HBBkqzWdvYLdjthqnZXerMYJlKfecWGss60vwGxPSEPGKc6-hvOv-qHFHqGL6qYKU53OWK7o1Qggp2HSiKLvTHbQ2IQG3bbpspEEf2Mfl47PenB_QalK4tbEEQW-Jkt9koelXyjDxtNkTUq3vznPS2-QuSKJJNQT7pUbJpI9lURLSWbBrCVeDTSrKpmNBOsivKTrJfknTiJ6NAa_J_aFtmGntNFm5pWKVlwhLMQG3iq2GeI0gYjkNhuZK7bGWX3FkbuFXhxdosmJMzBy9hqTJekdPd9518TejKsdeFqa-t0hzCQzKHsZMMI_rLIofyjCzrociua5CX7N_x_4ycw-hm5QZL2HBVxl_kvQEs5hZ78x_f_ZY8wc-1thm-I6f7m4M8By16X7yvpPE39Bi30w |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=FUNDAMENTAL+AND+CLINICAL+STUDIES+ON+TA-058+IN+THE+FIELD+OF+OBSTETRICS+AND+GYNECOLOGY&rft.jtitle=CHEMOTHERAPY&rft.au=SUGIYAMA%2C+SHUSEI&rft.au=DOI%2C+SOUNOSUKE&rft.au=SUGIMOTO%2C+OSAMU&rft.au=TSUJII%2C+KIYOSHIGE&rft.date=1984&rft.pub=Japanese+Society+of+Chemotherapy&rft.issn=0009-3165&rft.eissn=1884-5894&rft.volume=32&rft.issue=Supplement2&rft.spage=732&rft.epage=736&rft_id=info:doi/10.11250%2Fchemotherapy1953.32.Supplement2_732&rft.externalDocID=article_chemotherapy1953_32_Supplement2_32_Supplement2_732_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-3165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-3165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-3165&client=summon |