ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF SULTAMICILLIN

• Published in: CHEMOTHERAPY Vol. 33; no. Supplement2; pp. 102 - 111
• Main Authors: TACHIBANA, MASAKATSU, NABATA, HIROSHI, IIJIMA, MORITAKE, OHTSUKI, ISAO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1985

Acute, subacute and chronic toxicities of sultamicillin (SBTPC), a mutual prodrug of sulbactam and ampicillin were evaluated in Sprague-Dawley rats or ICR mice. The acute oral LD50 of SBTPC were estimated to be greater than 10000 mg/kg in rats and mice. In the subacute oral toxicity test, all rats t...