ACUTE, SUBACUTE AND CHRONIC TOXICITY STUDIES OF SULTAMICILLIN

Acute, subacute and chronic toxicities of sultamicillin (SBTPC), a mutual prodrug of sulbactam and ampicillin were evaluated in Sprague-Dawley rats or ICR mice. The acute oral LD50 of SBTPC were estimated to be greater than 10000 mg/kg in rats and mice. In the subacute oral toxicity test, all rats t...

Full description

Saved in:
Bibliographic Details
Published inCHEMOTHERAPY Vol. 33; no. Supplement2; pp. 102 - 111
Main Authors TACHIBANA, MASAKATSU, NABATA, HIROSHI, IIJIMA, MORITAKE, OHTSUKI, ISAO
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1985
Online AccessGet full text

Cover

Loading…
More Information
Summary:Acute, subacute and chronic toxicities of sultamicillin (SBTPC), a mutual prodrug of sulbactam and ampicillin were evaluated in Sprague-Dawley rats or ICR mice. The acute oral LD50 of SBTPC were estimated to be greater than 10000 mg/kg in rats and mice. In the subacute oral toxicity test, all rats treated with SBTPC (1000, 300, 100, 30mg/kg) for 1 month were well tolerated. Occasional soft stools were noted in the treated groups. The highest dose level (1000mg/kg) of SBTPC produced mild growth inhibition, slight decrease of the liver weight and enlarged cecum and a deposition of glycogen-like droplets in the hepatic cell cytoplasm without any functional abnormality and morphological lesions. The non-toxic dose of SBTPC is considered to be 300mg/kg. In the chronic toxicity test, the rats were treated orally with SBTPC (1000, 300, 100 and 30mg/kg) for 6 months. Deaths were noted in the high dose groups (1000 and 300 mg/kg). Other results were comparable to those in the subacute toxicity test. The non-toxic dose in the chronic toxicity test with SBTPC is considered to be 100mg/kg.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.33.Supplement2_102