CARUMONAM IN COMPLICATED URINARY TRACT INFECTIONS
Carumonam, a new monobactam antibiotic, was investigated for antibacterial activity, absorption and excretion, clinical evaluation and side effects. The results obtained were as follows: 1) Antibacterial activity of carumonam againstPseudomonas aeruginosawas equal to that of cefoperazone. Antibacter...
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| Published in | CHEMOTHERAPY Vol. 35; no. Supplement2; pp. 778 - 788 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1987
公益社団法人 日本化学療法学会 |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.35.Supplement2_778 |
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| Abstract | Carumonam, a new monobactam antibiotic, was investigated for antibacterial activity, absorption and excretion, clinical evaluation and side effects. The results obtained were as follows: 1) Antibacterial activity of carumonam againstPseudomonas aeruginosawas equal to that of cefoperazone. Antibacterial activity of carumonam againstEscherichia coli, Serratia marcescens, Proteus mirabilis, Proteus vulgaris, andKlebsiella pneumoniaewas superior to that of cefoperazone. Antibacterial activity againstE. coli, S. marcescens, P. mirabilis, P. vulgaris, K. pneumoniae, P. aeruginosawas almost equal to that of aztreonam. 2) Carumonam 1 g was administered by 30 min and by 1 h i. v. drip infusion to three healthy volunteers by a cross-over method. The maximum serum levels of carumonam after 30 min i. v. drip infusion was 88.6±16.2μg/ml, and the maximum serum levels after 1 h i.v. drip infusion was 67.1±8.8μg/ml. 3) Two patients with complicated urinary tract infections were treated with carumonam and good results were obtained in both cases. 4) Adverse reactions were evaluated in five cases; but the only side effects observed were slight increase in eosinophils in two cases, and slight increase of transaminase in one case. |
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| AbstractList | Carumonam, a new monobactam antibiotic, was investigated for antibacterial activity, absorption and excretion, clinical evaluation and side effects. The results obtained were as follows: 1) Antibacterial activity of carumonam againstPseudomonas aeruginosawas equal to that of cefoperazone. Antibacterial activity of carumonam againstEscherichia coli, Serratia marcescens, Proteus mirabilis, Proteus vulgaris, andKlebsiella pneumoniaewas superior to that of cefoperazone. Antibacterial activity againstE. coli, S. marcescens, P. mirabilis, P. vulgaris, K. pneumoniae, P. aeruginosawas almost equal to that of aztreonam. 2) Carumonam 1 g was administered by 30 min and by 1 h i. v. drip infusion to three healthy volunteers by a cross-over method. The maximum serum levels of carumonam after 30 min i. v. drip infusion was 88.6±16.2μg/ml, and the maximum serum levels after 1 h i.v. drip infusion was 67.1±8.8μg/ml. 3) Two patients with complicated urinary tract infections were treated with carumonam and good results were obtained in both cases. 4) Adverse reactions were evaluated in five cases; but the only side effects observed were slight increase in eosinophils in two cases, and slight increase of transaminase in one case. Carumonam, a new monobactam antibiotic, was investigated for antibacterial activity, absorption and excretion, clinical evaluation and side effects.The results obtained were as follows:1) Antibacterial activity of carumonam againstPseudomonas aeruginosawas equal to that of cefoperazone. Antibacterial activity of carumonam againstEscherichia coli, Serratia marcescens, Proteus mirabilis, Proteus vulgaris, andKlebsiella pneumoniaewas superior to that of cefoperazone. Antibacterial activity againstE. coli, S. marcescens, P. mirabilis, P. vulgaris, K. pneumoniae, P. aeruginosawas almost equal to that of aztreonam.2) Carumonam 1 g was administered by 30 min and by 1 h i. v. drip infusion to three healthy volunteers by a cross-over method. The maximum serum levels of carumonam after 30 min i. v. drip infusion was 88.6±16.2μg/ml, and the maximum serum levels after 1 h i.v. drip infusion was 67.1±8.8μg/ml.3) Two patients with complicated urinary tract infections were treated with carumonam and good results were obtained in both cases.4) Adverse reactions were evaluated in five cases; but the only side effects observed were slight increase in eosinophils in two cases, and slight increase of transaminase in one case. Carumonamについて基礎的・臨床的検討を行い以下の結果を得た。1. 尿路感染症より分離したEscherichia coli, Serratia marcescens, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumoniae, Pseudomonas aeruginosaに対する本剤, cefoperazone (CPZ), aztreonam (AZT) のMICを測定し, CPZに比しP. aeruginosaで同等の抗菌力を示したほかは, 他の菌種は1～9管程度優れた抗菌力を有していた。AZTとの比較ではほぼ同程度の抗菌力を示した。2. 健康成人3名に本剤1gを30分および1時間点滴静注し, 血中, 尿中濃度を測定した。血中濃度は30分および1時間点滴静注いずれも点滴終了時にpeakを示し, 前者では平均88.6±16.2μg/ml, 後者では平均67.1±8.8μg/mlであった。尿中濃度は0～2時間で最高濃度を示し, 30分点滴静注では5035±3698μg/ml, 1時間点滴静注では3761±2181μg/mlで, 6時間までの尿中回収率は86.4～95.8%と非常に良好であった。3. 複雑性尿路感染症5例を対象に本剤1日2gを朝, 夕2回に分け, 30分点滴静注し, その薬効をUTI基準に従って検討した。除外, 脱落を除く2例の総合臨床効果は2例とも有効であった。自他覚的副作用は全例で認めず, 臨床検査値で異常を示したものもいずれも一過性, 軽度であり, 本剤があきらかな原因と思われたものはなかった。 |
| Author | SUGITA, OSAMU FUJITA, YUKITOSHI MATSUMOTO, SHIGERU WATANABE, HIRONOBU |
| Author_FL | 渡辺 裕修 藤田 幸利 杉田 治 松本 茂 |
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| Author_xml | – sequence: 1 fullname: WATANABE, HIRONOBU organization: Department of Urology, Kochi Medical School – sequence: 1 fullname: FUJITA, YUKITOSHI organization: Department of Urology, Kochi Medical School – sequence: 1 fullname: MATSUMOTO, SHIGERU organization: Department of Urology, Kochi Medical School – sequence: 1 fullname: SUGITA, OSAMU organization: Department of Urology, Kochi Medical School |
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| References | 4) 守殿貞夫, 藤井明, 田珠相, 川端岳, 岡田弘, 原田益善, 荒川創一, 石神襄次: 尿路感染分離菌の年次的変遷および薬剤感受性について. 西日泌尿 47: 1611-1617, 1985 3) 第33回日本化学療法学会西日本支部総会, 新薬シンポジウムII, Carumonam (AMA-1080). 大阪, 1985 5) 松本茂, 杉田治, 山下元幸, 戦泰和, 小倉朱生, 山本志雄, 大橋洋三, 亀井義広, 森岡政明, 藤田幸利: 複雑性尿路感染症に対するAztreonamの基礎的・臨床的検討. 西日泌尿 47: 1253-1263, 1985 2) 大越正秋 (UTI研究会代表): UTI薬効評価基準 (第2版). Chemotherapy 28: 324-341, 1980 1) MIC測定法改定委員会: 最小発育阻止濃度 (MIC) 測定法再改定について. Chemotherapy 29: 76-79, 1981 |
| References_xml | – reference: 2) 大越正秋 (UTI研究会代表): UTI薬効評価基準 (第2版). Chemotherapy 28: 324-341, 1980 – reference: 1) MIC測定法改定委員会: 最小発育阻止濃度 (MIC) 測定法再改定について. Chemotherapy 29: 76-79, 1981 – reference: 5) 松本茂, 杉田治, 山下元幸, 戦泰和, 小倉朱生, 山本志雄, 大橋洋三, 亀井義広, 森岡政明, 藤田幸利: 複雑性尿路感染症に対するAztreonamの基礎的・臨床的検討. 西日泌尿 47: 1253-1263, 1985 – reference: 4) 守殿貞夫, 藤井明, 田珠相, 川端岳, 岡田弘, 原田益善, 荒川創一, 石神襄次: 尿路感染分離菌の年次的変遷および薬剤感受性について. 西日泌尿 47: 1611-1617, 1985 – reference: 3) 第33回日本化学療法学会西日本支部総会, 新薬シンポジウムII, Carumonam (AMA-1080). 大阪, 1985 |
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| Snippet | Carumonam, a new monobactam antibiotic, was investigated for antibacterial activity, absorption and excretion, clinical evaluation and side effects. The... Carumonam, a new monobactam antibiotic, was investigated for antibacterial activity, absorption and excretion, clinical evaluation and side effects.The results... |
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| Title | CARUMONAM IN COMPLICATED URINARY TRACT INFECTIONS |
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