BMY-28100 IN SURGICAL SKIN AND SOFT-TISSUE INFECTIONS

We conducted a clinical evaluation of BMY-28100, a new non-ester type cephalosporin, in the surgical field. BMY-28100 was administered to 24 patients with various surgical infections, without 2 drop out cases. The clinical effect was excellent in 3, good in 19, fair in none and poor in 2, with an ov...

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Published inCHEMOTHERAPY Vol. 37; no. Supplement3; pp. 715 - 723
Main Authors YOKOYAMA, ISAO, TSUYUKI, KEN, SAITO, TOSHIAKI, NAKATSU, TAKAYOSHI, ARAI, TAKEYUKI
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1989
公益社団法人 日本化学療法学会
Subjects
BMY-28100
外科的感染症
皮膚軟部組織感染症
細菌学的効果
臨床効果
Online AccessGet full text
ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.37.Supplement3_715

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Abstract We conducted a clinical evaluation of BMY-28100, a new non-ester type cephalosporin, in the surgical field. BMY-28100 was administered to 24 patients with various surgical infections, without 2 drop out cases. The clinical effect was excellent in 3, good in 19, fair in none and poor in 2, with an overall efficacy rate of 91.7%. High clinical efficacy was observed in infectious atheroma, paronychia, abscess and mastitis, the efficacy rate for these diseases being 87.5%, 100%, 100% and 100%, respectively. The clinical efficacy rate classified by isolated organism was as follows: 100%(12/12) against Gram-positive cocci, 100%(7/7) against Gram-negative bacilli and 100%(9/9) against anaerobes. The eradication rate was 100%. No side effects due to administration of BMY-28100 were experienced, and no abnormal laboratory findings ocurred in any of the cases.
AbstractList We conducted a clinical evaluation of BMY-28100, a new non-ester type cephalosporin, in the surgical field. BMY-28100 was administered to 24 patients with various surgical infections, without 2 drop out cases. The clinical effect was excellent in 3, good in 19, fair in none and poor in 2, with an overall efficacy rate of 91.7%. High clinical efficacy was observed in infectious atheroma, paronychia, abscess and mastitis, the efficacy rate for these diseases being 87.5%, 100%, 100% and 100%, respectively. The clinical efficacy rate classified by isolated organism was as follows: 100%(12/12) against Gram-positive cocci, 100%(7/7) against Gram-negative bacilli and 100%(9/9) against anaerobes. The eradication rate was 100%. No side effects due to administration of BMY-28100 were experienced, and no abnormal laboratory findings ocurred in any of the cases.
We conducted a clinical evaluation of BMY-28100, a new non-ester type cephalosporin, in the surgical field.BMY-28100 was administered to 24 patients with various surgical infections, without 2 drop out cases. The clinical effect was excellent in 3, good in 19, fair in none and poor in 2, with an overall efficacy rate of 91.7%. High clinical efficacy was observed in infectious atheroma, paronychia, abscess and mastitis, the efficacy rate for these diseases being 87.5%, 100%, 100% and 100%, respectively.The clinical efficacy rate classified by isolated organism was as follows: 100%(12/12) against Gram-positive cocci, 100%(7/7) against Gram-negative bacilli and 100%(9/9) against anaerobes. The eradication rate was 100%.No side effects due to administration of BMY-28100 were experienced, and no abnormal laboratory findings ocurred in any of the cases. 外科領域における皮膚軟部組織感染症に対する非エステル型のセフェム系経口抗生物質BMY-28100の臨床的検討を行った。効果判定不能2例を除いた外科的感染症24例に対する臨床効果は, 著効3, 有効19, やや有効0, 無効2で, 有効率は91.7%であった。この中で, 感染性粉瘤, 爪周囲炎, 膿瘍, 乳腺炎に対する有効率はそれぞれ87.5%(7/8), 100%(4/4), 100%(4/4), 100%(4/4) と良好であった。分離菌別の臨床効果は, グラム陽性球菌で12/12, グラム陰性桿菌で7/7, 嫌気性菌で9/9と有効率100%であった。分離菌別の細菌学的効果 (不明を除く) も100%であった。本剤投与に起因すると思われる自他覚的副作用は認められず, また臨床検査値異常も認められなかった。
Author NAKATSU, TAKAYOSHI
YOKOYAMA, ISAO
TSUYUKI, KEN
SAITO, TOSHIAKI
ARAI, TAKEYUKI
Author_FL 新井 健之
斎藤 敏明
中津 喬義
横山 勲
露木 建
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  organization: Department of Surgery, Kawasaki Municipal Kawasaki Hospital
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  organization: Department of Surgery, Kawasaki Municipal Kawasaki Hospital
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  organization: Department of Surgery, Kawasaki Municipal Kawasaki Hospital
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  organization: Department of Surgery, Kawasaki Municipal Kawasaki Hospital
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  fullname: ARAI, TAKEYUKI
  organization: Department of Surgery, Kawasaki Municipal Kawasaki Hospital
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References 1) BMY-28100説明書: プリストル・マイヤーズ研究所株式会社, Mar. 1987
2) 第1回BMY-28100研究会発表資料集: ブリストル・マイヤーズ研究所株式会社, Aug. 1987
3) 第37回日本化学療法学会総会, 新薬シンポジウム. BMY-28100, 東京, 1989
References_xml – reference: 1) BMY-28100説明書: プリストル・マイヤーズ研究所株式会社, Mar. 1987
– reference: 3) 第37回日本化学療法学会総会, 新薬シンポジウム. BMY-28100, 東京, 1989
– reference: 2) 第1回BMY-28100研究会発表資料集: ブリストル・マイヤーズ研究所株式会社, Aug. 1987
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Snippet We conducted a clinical evaluation of BMY-28100, a new non-ester type cephalosporin, in the surgical field. BMY-28100 was administered to 24 patients with...
We conducted a clinical evaluation of BMY-28100, a new non-ester type cephalosporin, in the surgical field.BMY-28100 was administered to 24 patients with...
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SubjectTerms BMY-28100
外科的感染症
皮膚軟部組織感染症
細菌学的効果
臨床効果
Title BMY-28100 IN SURGICAL SKIN AND SOFT-TISSUE INFECTIONS
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