STUDIES ON AC-1370 IN THE FIELD OF OPHTHALMOLOGY

• Published in: CHEMOTHERAPY Vol. 32; no. Supplement9; pp. 827 - 830
• Main Authors: BABA, YASUHIKO, HATANO, HIROSHI, ONISHI, HITOMI
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1984; 公益社団法人 日本化学療法学会
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.32.Supplement9_827

Fundamental and clinical studies on AC-1370, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained. 1. The MIC of AC-1370 against Staphylococcus aureus isolated from infectious eye diseases ranged from 12.5-100μg/ml, and MIC of AC-1370 against Klebsiella pneumoniae ranged from 1.56-50μg/ml. 2. Aqueous humor concentration of AC-1370 reached maximum (2.6μg/ml) at 1 hour after an i.v. administration of 50mg/kg in rabbits, and the maximum serum concentration (21.0μg/ml) was obtained at 30 minutes after the injection. 3. High concentration in tear and low concentration in aqueous humor were measured after i.v. administration of 50mg/kg AC-1370 in rabbits. 4. Aqueous humor concentration of AC-1370 in rabbits reached peak at 11 hour after subconjunctival injection 10mg/0.1ml and the peak aqueous humor level was 10.1μg/ml. 5. Two patients with ocular suppurative diseases were successfully treated at a daily dose of 1, 000, 2, 000mg AC-1370. 6, No side effect were observed.