CLINICAL EFFICACY AND TRANSFER OF BMY-28100 TO BLOOD AND SKIN
We performed basic and clinical studies on BMY-28100 in dermatological infections, with the following results. 1. Five-hundred mg of BMY-28100 was orally administered to 9 patients with benign skin tumors, and 2h later the blood level of the drug and its transfer to the skin were determined. The mea...
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| Published in | CHEMOTHERAPY Vol. 37; no. Supplement3; pp. 823 - 826 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1989
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.37.Supplement3_823 |
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| Abstract | We performed basic and clinical studies on BMY-28100 in dermatological infections, with the following results. 1. Five-hundred mg of BMY-28100 was orally administered to 9 patients with benign skin tumors, and 2h later the blood level of the drug and its transfer to the skin were determined. The mean concentration of BMY-28100 was 9.16μg/ml in blood and 2.24μg/g in dermal tissue. 2. We carried out a clinical study on 12 patients with skin disease. The clinical efficacy rate was about 92%. |
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| AbstractList | We performed basic and clinical studies on BMY-28100 in dermatological infections, with the following results. 1. Five-hundred mg of BMY-28100 was orally administered to 9 patients with benign skin tumors, and 2h later the blood level of the drug and its transfer to the skin were determined. The mean concentration of BMY-28100 was 9.16μg/ml in blood and 2.24μg/g in dermal tissue. 2. We carried out a clinical study on 12 patients with skin disease. The clinical efficacy rate was about 92%. We performed basic and clinical studies on BMY-28100 in dermatological infections, with the following results.1. Five-hundred mg of BMY-28100 was orally administered to 9 patients with benign skin tumors, and 2h later the blood level of the drug and its transfer to the skin were determined. The mean concentration of BMY-28100 was 9.16μg/ml in blood and 2.24μg/g in dermal tissue.2. We carried out a clinical study on 12 patients with skin disease. The clinical efficacy rate was about 92%. BMY-28100の皮膚組織内移行濃度に関する基礎的検討を行うとともに, その臨床効果について検討した。1. 9例の皮膚良性腫瘍患者についてBMY-28100 500mg経口投与2時間後の皮膚組織内移行濃度および血清中濃度は各々平均2.24μg/g, 9.16μg/mlであった。2. 12例の皮膚疾患について本剤を経口投与し, その臨床効果について検討した結果, 有効率は約92%であった。 |
| Author | SHINOMIYA, SHIGERU OHTA, MIDORI TODA, KIYOSHI SHONO, SHIGEAKI OSAKU, AYA |
| Author_FL | 太田 みどり 四宮 茂 尾作 文 生野 重明 戸田 淨 |
| Author_FL_xml | – sequence: 1 fullname: 太田 みどり – sequence: 2 fullname: 生野 重明 – sequence: 3 fullname: 四宮 茂 – sequence: 4 fullname: 尾作 文 – sequence: 5 fullname: 戸田 淨 |
| Author_xml | – sequence: 1 fullname: SHINOMIYA, SHIGERU organization: Department of Dermatology, Tokyo Teishin Hospital – sequence: 1 fullname: TODA, KIYOSHI organization: Department of Dermatology, Tokyo Teishin Hospital – sequence: 1 fullname: OHTA, MIDORI organization: Department of Dermatology, Tokyo Teishin Hospital – sequence: 1 fullname: SHONO, SHIGEAKI organization: Department of Dermatology, Tokyo Teishin Hospital – sequence: 1 fullname: OSAKU, AYA organization: Department of Dermatology, Tokyo Teishin Hospital |
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| DocumentTitleAlternate | BMY-28100の臨床試験および皮膚組織内移行濃度の検討 |
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| Publisher | Japanese Society of Chemotherapy 公益社団法人 日本化学療法学会 |
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| References | 1) 第37回日本化学療法学会総会, 新薬シンポジウム. BMY-28100, 東京, 1989 |
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| Snippet | We performed basic and clinical studies on BMY-28100 in dermatological infections, with the following results. 1. Five-hundred mg of BMY-28100 was orally... We performed basic and clinical studies on BMY-28100 in dermatological infections, with the following results.1. Five-hundred mg of BMY-28100 was orally... |
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| SubjectTerms | BMY-28100皮膚感染症 皮膚組織濃度 臨床検討 |
| Title | CLINICAL EFFICACY AND TRANSFER OF BMY-28100 TO BLOOD AND SKIN |
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