In vitro activities of pazufloxacin, an injectable new quinolone, against bacteria causing infections in obstetric and gynecological patients
Pazufloxacin is an injectable new quinolone with a broad spectrum of antibacterial activity. The MICs of pazufloxacin for 50% of the clinical isolates tested were 3.13μg/ml for Streptococcus agalactiae, 6.25μg/ml for Gardnerella vaginalis, 0.025μg/ml for Escherichiu coli, 0.78μg/ml for Pseudomonas a...
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| Published in | Japanese Journal of Chemotherapy Vol. 47; no. Supplement1; pp. 21 - 24 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
1999
公益社団法人 日本化学療法学会 |
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| Online Access | Get full text |
| ISSN | 1340-7007 1884-5886 |
| DOI | 10.11250/chemotherapy1995.47.Supplement1_21 |
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| Abstract | Pazufloxacin is an injectable new quinolone with a broad spectrum of antibacterial activity. The MICs of pazufloxacin for 50% of the clinical isolates tested were 3.13μg/ml for Streptococcus agalactiae, 6.25μg/ml for Gardnerella vaginalis, 0.025μg/ml for Escherichiu coli, 0.78μg/ml for Pseudomonas aeruginosa, 6.25μg/ml for Peptostreptococcus magnus, 6.25μg ml for Bucteroides fragilis and 12.5 μg/ml for Prevotella bivia. The MICs of pazufloxacin for 90 % of the clinical isolates tested were 3.13 μg/ml for S. agalactiae, 6.25 μg/ml for G. vaginalis, 0.10 μg/ml for E. coli, 12.5 μg/ml for P. aeruginosa, 25 μg/ml for P. magnus, 12.5 fig/ml for B. fragilis and 25 μg/ml for P. hivia. The results of this study suggest that, subject to confirmation by clinical trials, pazufloxacin, in combination with an agent with reliable activity against anaerobic bacteria, issuitable as empirical therapy of patients with obstetric and gynecological infections. |
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| AbstractList | Pazufloxacin is an injectable new quinolone with a broad spectrum of antibacterial activity. The MICs of pazufloxacin for 50% of the clinical isolates tested were 3.13μg/ml for Streptococcus agalactiae, 6.25μg/ml for Gardnerella vaginalis, 0.025μg/ml for Escherichiu coli, 0.78μg/ml for Pseudomonas aeruginosa, 6.25μg/ml for Peptostreptococcus magnus, 6.25μg ml for Bucteroides fragilis and 12.5 μg/ml for Prevotella bivia. The MICs of pazufloxacin for 90 % of the clinical isolates tested were 3.13 μg/ml for S. agalactiae, 6.25 μg/ml for G. vaginalis, 0.10 μg/ml for E. coli, 12.5 μg/ml for P. aeruginosa, 25 μg/ml for P. magnus, 12.5 fig/ml for B. fragilis and 25 μg/ml for P. hivia. The results of this study suggest that, subject to confirmation by clinical trials, pazufloxacin, in combination with an agent with reliable activity against anaerobic bacteria, issuitable as empirical therapy of patients with obstetric and gynecological infections. Pazufloxacin is an injectable new quinolone with a broad spectrum of antibacterial activity.The MICs of pazufloxacin for 50% of the clinical isolates tested were 3.13μg/ml for Streptococcus agalactiae, 6.25μg/ml for Gardnerella vaginalis, 0.025μg/ml for Escherichiu coli, 0.78μg/ml for Pseudomonas aeruginosa, 6.25μg/ml for Peptostreptococcus magnus, 6.25μg ml for Bucteroides fragilis and 12.5 μg/ml for Prevotella bivia. The MICs of pazufloxacin for 90 % of the clinical isolates tested were 3.13 μg/ml for S. agalactiae, 6.25 μg/ml for G. vaginalis, 0.10 μg/ml for E. coli, 12.5 μg/ml for P. aeruginosa, 25 μg/ml for P. magnus, 12.5 fig/ml for B. fragilis and 25 μg/ml for P. hivia. The results of this study suggest that, subject to confirmation by clinical trials, pazufloxacin, in combination with an agent with reliable activity against anaerobic bacteria, issuitable as empirical therapy of patients with obstetric and gynecological infections. 新しく開発された合成抗菌薬pazufloxacin注射薬 (PZFX注射薬) について, 産婦人科領域臨床分離菌株に対する抗菌力上pazufloxacin (PZFX) を用いて検討し, 以下の成績を得た.産婦人科領域細菌感染症から分離された7菌種226株上用いてPZFXの抗菌力上ciprofloxacin (CPFX), ceftazidime (CAZ), imipenem (IPM), gentamicin (GM) 上比較薬剤として寒天平板希釈法により検討した.S.agalactiaeに対するPZFXのMIC90.値は, 3.13μg/mlであり, CPFXより4倍劣っていたが, IPMと同等で, CAZより2倍優れていた.Gvaginalisに対するPZFXのMIC90値は, 6.25μg/mlで, CPFXと同等で, CAZ, IPMより2～16倍劣っていた. E. coliに対するPZFXのMICg。値は, 0.10μg/mlであり, CPFXと同等で, CAZ, IPM, GMより優れていた.Paeruginosaに対するPZFXのMIC90.値は, 12.5μg/mlであり, CPFX, IPMより2倍劣っていたがCAZと同等で, GMより4倍優れていた. P. aeruginosaに対するPZFXのMIC50値は6.25μg/ml, MIC90値は, 25μg/mlであり, CPFX, GMとほぼ同等で, CAZ, IPMより劣っていた。B.fragilisに対するPZFXのMIC50値は, 6.25μg/mlであり, IPMより16倍劣っていたが, CPFXと同等で, CAZより4倍優れていた。P.biviaに対するPZFXのMIC50値は, 12.5μg/mlであり, IPMより8倍劣っていたが, CPFX, CAZより2倍優れていた。PZFXは, S. agalactiae, Ecoliなどの好気性菌およびP.magnus上代表とする嫌気性グラム陽性球菌に対しては良好な抗菌力上示したが, B.fragilis, P.biviaなどの嫌気性グラム陰性菌に対しての抗菌力は十分とは言えなかった. |
| Author | Sato, Yasumasa Izumi, Koji Ito, Kunihiko Mikamo, Hiroshige Tamaya, Teruhiko Kawazoe, Kyoko Yamada, Yoshitaka Hayasaki, Yoh |
| Author_FL | 山田 新尚 三鴨 廣繁 佐藤 泰昌 和泉 孝治 伊藤 邦彦 玉舎 輝彦 早崎 容 川添 香子 |
| Author_FL_xml | – sequence: 1 fullname: 三鴨 廣繁 – sequence: 2 fullname: 佐藤 泰昌 – sequence: 3 fullname: 早崎 容 – sequence: 4 fullname: 川添 香子 – sequence: 5 fullname: 和泉 孝治 – sequence: 6 fullname: 伊藤 邦彦 – sequence: 7 fullname: 山田 新尚 – sequence: 8 fullname: 玉舎 輝彦 |
| Author_xml | – sequence: 1 fullname: Hayasaki, Yoh organization: Department of Obstetrics and Gynecology, School of Medicine, Gifu University – sequence: 1 fullname: Sato, Yasumasa organization: Department of Obstetrics and Gynecology, School of Medicine, Gifu University – sequence: 1 fullname: Tamaya, Teruhiko organization: Department of Obstetrics and Gynecology, School of Medicine, Gifu University – sequence: 1 fullname: Kawazoe, Kyoko organization: Department of Obstetrics and Gynecology, Ibi General Hospital – sequence: 1 fullname: Izumi, Koji organization: Department of Obstetrics and Gynecology, Gihoku General Hospital – sequence: 1 fullname: Mikamo, Hiroshige organization: Department of Obstetrics and Gynecology, School of Medicine, Gifu University – sequence: 1 fullname: Yamada, Yoshitaka organization: Department of Obstetrics and Gynecology, Gifu Prefectural Gifu Hospital – sequence: 1 fullname: Ito, Kunihiko organization: Department of Obstetrics and Gynecology, Gifu Municipal Hospital |
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| References | 2) 岡田弘二, 小林宏行: 第45回日本化学療法学会西日本支部総会, T-3762の基礎及び臨床評価. 京都, 1997 3) Mikamo H, Kawazoe K, Sato Y, et al.: Therapeutic effects of an injectable newquinolone, pazufloxacin, against polymicrobial infections in the uterine endometritis model. Chemotheray 44: 99-102, 1998 1) Todo Y, Takagi H, Fukuoka Y, et al.: Pyridonecarboxylic acids as antibacteria lagents. IX. Synthesis and structure-activity relationship of 3-substituted 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2, 3-dihydro-7H-pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acids and their 1-thio and 1-aza analogues. Chem Pharm Bull 42: 2569-2574, 1994 4) 三鴨廣繁, 川添香子, 佐藤泰昌, 他: 1996年の岐阜大学医学部産科婦人科の原因菌と静注用抗菌薬の使用状況. 新薬と臨床47: 146-154, 1998 |
| References_xml | – reference: 4) 三鴨廣繁, 川添香子, 佐藤泰昌, 他: 1996年の岐阜大学医学部産科婦人科の原因菌と静注用抗菌薬の使用状況. 新薬と臨床47: 146-154, 1998 – reference: 2) 岡田弘二, 小林宏行: 第45回日本化学療法学会西日本支部総会, T-3762の基礎及び臨床評価. 京都, 1997 – reference: 1) Todo Y, Takagi H, Fukuoka Y, et al.: Pyridonecarboxylic acids as antibacteria lagents. IX. Synthesis and structure-activity relationship of 3-substituted 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2, 3-dihydro-7H-pyrido [1, 2, 3-de]-1, 4-benzoxazine-6-carboxylic acids and their 1-thio and 1-aza analogues. Chem Pharm Bull 42: 2569-2574, 1994 – reference: 3) Mikamo H, Kawazoe K, Sato Y, et al.: Therapeutic effects of an injectable newquinolone, pazufloxacin, against polymicrobial infections in the uterine endometritis model. Chemotheray 44: 99-102, 1998 |
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| Snippet | Pazufloxacin is an injectable new quinolone with a broad spectrum of antibacterial activity. The MICs of pazufloxacin for 50% of the clinical isolates tested... Pazufloxacin is an injectable new quinolone with a broad spectrum of antibacterial activity.The MICs of pazufloxacin for 50% of the clinical isolates tested... |
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| Title | In vitro activities of pazufloxacin, an injectable new quinolone, against bacteria causing infections in obstetric and gynecological patients |
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