An open trial of risperidone in autistic children

• Published in: No to hattatsu Vol. 35; no. 6; p. 473
• Main Authors: Nishimura, Mio, Hashimoto, Toshiaki, Miyazaki, Masahito, Mori, Kenji, Kuroda, Yasuhiro
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2003
• Subjects: Antipsychotic Agents - administration & dosage; Antipsychotic Agents - adverse effects; Autistic Disorder - drug therapy; Autistic Disorder - psychology; Child; Child Behavior; Child, Preschool; Dopamine Antagonists - administration & dosage; Dopamine Antagonists - adverse effects; Female; Humans; Male; Psychiatric Status Rating Scales; Risperidone - administration & dosage; Risperidone - adverse effects; Serotonin Antagonists - administration & dosage; Serotonin Antagonists - adverse effects; Treatment Outcome
• ISSN: 0029-0831
• DOI: 10.11251/ojjscn1969.35.473

Clinical effects of risperidone were evaluated in 9 young autistic children under informed consent of their parents. The patients were evaluated by the Children's Behavioral Checklist and Rutter's Autistic Behavioral Rating Scale. After the administration, two subjects (playing and adaptation to change) of the Children's Behavioral Checklist and four (anomalous autistic behavior, destructive behavior, developmental problem and activity level) of the Rutter's Autistic Behavioral Rating Scale were improved significantly. There were no serious side effects such as extrapyramidal symptoms except minor adverse effects including sedation, depression, increased appetite and constipation. Risperidone might be effective for serious behavioral disturbances in young autistic children.