A Case of Interferon-α-induced Pneumonitis
We report a case of interferon-α-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3×106 unit of interferon-α daily for 8 weeks. On the 55th injection, he presented with a high fever and mild dyspnea, and his chest CT films revealed di...
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| Published in | Nihon Kyōbu Shikkan Gakkai zasshi Vol. 31; no. 10; pp. 1308 - 1312 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japan
The Japanese Respiratory Society
01.10.1993
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-1542 1883-471X |
| DOI | 10.11389/jjrs1963.31.1308 |
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| Abstract | We report a case of interferon-α-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3×106 unit of interferon-α daily for 8 weeks. On the 55th injection, he presented with a high fever and mild dyspnea, and his chest CT films revealed diffuse reticulonodular shadows in both lung fields. We suspected interstitial pneumonitis due to interferon-α, and started steroid therapy. He showed rapid improvement of symptoms and diffusing capacity, and the pulmonary infitrates in his chest CT were markedly reduced. Transbronchial lung biopsy (TBLB) revealed slightly thickened alveolar walls and small granulomatous-like lesions. These granulomatous-like lesions showed marked accumulation of macrophages. To our knowledge, this is the first report of interferon-α-induced pulmonary injury in Japan |
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| AbstractList | We report a case of interferon-alpha-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3 x 10(6) unit of interferon-alpha daily for 8 weeks. On the 55th injection, he presented with a high fever and mild dyspnea, and his chest CT films revealed diffuse reticulonodular shadows in both lung fields. We suspected interstitial pneumonitis due to interferon-alpha, and started steroid therapy. He showed rapid improvement of symptoms and diffusing capacity, and the pulmonary infiltrates in his chest CT were markedly reduced. Transbronchial lung biopsy (TBLB) revealed slightly thickened alveolar walls and small granulomatous-like lesions. These granulomatous-like lesions showed marked accumulation of macrophages. To our knowledge, this is the first report of interferon-alpha-induced pulmonary injury in Japan. We report a case of interferon-alpha-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3 x 10(6) unit of interferon-alpha daily for 8 weeks. On the 55th injection, he presented with a high fever and mild dyspnea, and his chest CT films revealed diffuse reticulonodular shadows in both lung fields. We suspected interstitial pneumonitis due to interferon-alpha, and started steroid therapy. He showed rapid improvement of symptoms and diffusing capacity, and the pulmonary infiltrates in his chest CT were markedly reduced. Transbronchial lung biopsy (TBLB) revealed slightly thickened alveolar walls and small granulomatous-like lesions. These granulomatous-like lesions showed marked accumulation of macrophages. To our knowledge, this is the first report of interferon-alpha-induced pulmonary injury in Japan.We report a case of interferon-alpha-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3 x 10(6) unit of interferon-alpha daily for 8 weeks. On the 55th injection, he presented with a high fever and mild dyspnea, and his chest CT films revealed diffuse reticulonodular shadows in both lung fields. We suspected interstitial pneumonitis due to interferon-alpha, and started steroid therapy. He showed rapid improvement of symptoms and diffusing capacity, and the pulmonary infiltrates in his chest CT were markedly reduced. Transbronchial lung biopsy (TBLB) revealed slightly thickened alveolar walls and small granulomatous-like lesions. These granulomatous-like lesions showed marked accumulation of macrophages. To our knowledge, this is the first report of interferon-alpha-induced pulmonary injury in Japan. We report a case of interferon-α-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3×106 unit of interferon-α daily for 8 weeks. On the 55th injection, he presented with a high fever and mild dyspnea, and his chest CT films revealed diffuse reticulonodular shadows in both lung fields. We suspected interstitial pneumonitis due to interferon-α, and started steroid therapy. He showed rapid improvement of symptoms and diffusing capacity, and the pulmonary infitrates in his chest CT were markedly reduced. Transbronchial lung biopsy (TBLB) revealed slightly thickened alveolar walls and small granulomatous-like lesions. These granulomatous-like lesions showed marked accumulation of macrophages. To our knowledge, this is the first report of interferon-α-induced pulmonary injury in Japan |
| Author | Miura, Sumihiko Kawakami, Yoshikazu Suzuki, Junichi Watanabe, Naomi Yamaguchi, Etsuro |
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| References | 3) 今西二郎: サイトカイン―がんと闘う生体内物質, p. 42, 講談社, 東京, 1986. 6) 三浦淳彦, 金谷晶子, 足立智昭, 藤田淳, 島田直樹, 佐々木香織, 鈴木潤一, 川上義一: C型慢性肝炎に対するインターフェロンα療法の気管支肺胞洗浄液検査所見に与える影響. 日消誌, 89: 337, 1992. 5) 徳永徹: 感染症とマクロファージ. アクロファージ, p. 136, 講談社, 東京, 1987. 1) Spiegel, R. J.: The alpha interferons: Clinical overview. Semin. Oncol., 14: 1, 1987 (Suppl 2). 4) Abdi, E. A., Nguyen, G., Ludwig, R. N. & Dickout, W. J.: Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma. Cancer, 59: 896, 1987. 2) Muss, H. B., Costanzi, J. J., Leavitt, R., Williams, R. D., Kempf, R. A., Pollard, R., Ozer, H., Zekan, P. J., Grunberg, S. M., Mitchell, M. S., Caponera, M., Gavigan, M., Ernest, M. L., Venturi, C., Greiner, J. & Spiegel, R. J.: Recombinant alfa interferon in renal cell carcinoma: A randomized trial of two routes of administration. J. Clin. Oncol., 5: 286, 1987. |
| References_xml | – reference: 5) 徳永徹: 感染症とマクロファージ. アクロファージ, p. 136, 講談社, 東京, 1987. – reference: 3) 今西二郎: サイトカイン―がんと闘う生体内物質, p. 42, 講談社, 東京, 1986. – reference: 2) Muss, H. B., Costanzi, J. J., Leavitt, R., Williams, R. D., Kempf, R. A., Pollard, R., Ozer, H., Zekan, P. J., Grunberg, S. M., Mitchell, M. S., Caponera, M., Gavigan, M., Ernest, M. L., Venturi, C., Greiner, J. & Spiegel, R. J.: Recombinant alfa interferon in renal cell carcinoma: A randomized trial of two routes of administration. J. Clin. Oncol., 5: 286, 1987. – reference: 6) 三浦淳彦, 金谷晶子, 足立智昭, 藤田淳, 島田直樹, 佐々木香織, 鈴木潤一, 川上義一: C型慢性肝炎に対するインターフェロンα療法の気管支肺胞洗浄液検査所見に与える影響. 日消誌, 89: 337, 1992. – reference: 4) Abdi, E. A., Nguyen, G., Ludwig, R. N. & Dickout, W. J.: Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma. Cancer, 59: 896, 1987. – reference: 1) Spiegel, R. J.: The alpha interferons: Clinical overview. Semin. Oncol., 14: 1, 1987 (Suppl 2). |
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| Snippet | We report a case of interferon-α-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3×106 unit... We report a case of interferon-alpha-induced pneumonitis. A 61-year-old man was diagnosed as having recurrence of renal cell carcinoma and treated with 3 x... |
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| SubjectTerms | Carcinoma, Renal Cell - therapy Drug-induced pneumonitis Humans Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Interferon-α Kidney Neoplasms - therapy Lung Diseases, Interstitial - chemically induced Male Middle Aged |
| Title | A Case of Interferon-α-induced Pneumonitis |
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