A Case of Bronchiectasis Accompanied by Ulcerative Colitis (UC) and HTLV-1 Associated Myelopathy (HAM)
We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, ches...
Saved in:
| Published in | Nihon Kyōbu Shikkan Gakkai zasshi Vol. 32; no. 4; pp. 358 - 363 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
The Japanese Respiratory Society
01.04.1994
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-1542 1883-471X |
| DOI | 10.11389/jjrs1963.32.358 |
Cover
| Abstract | We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, chest X-ray films, tomography and CT-scan revealed dilated lumens and thickened airway walls extending from the trachea to subsegmental bronchi. Pulmonary function tests showed hypoxemia and mixed ventilatory disturbance with a predominantly obstructive component. HAM was diagnosed on the basis of neurological examination and cerebrospinal fluid analysis. A biopsy specimen from the carinal mucosa showed marked T cell infiltration. In these T cells, we detected polyclonal integration of HTLV-1 proviral DNA. Some of the infiltrating T cells showed atypia. In recent times, respiratory diseases other than infiltration of adult T-cell leukemia cells or opportunistic infection have been reported in HTLV-1 carriers and new clinical entities designated as HABA (HTLV-1 associated bronchiolo-alveolar disorder) and HBA (HTLV-1 associated bronchopneumonopathy) have been proposed. This case is classified among these new entities, in a broad sense, and is a rare case in that the respiratory disorder is apparently related to UC. |
|---|---|
| AbstractList | We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, chest X-ray films, tomography and CT-scan revealed dilated lumens and thickened airway walls extending from the trachea to subsegmental bronchi. Pulmonary function tests showed hypoxemia and mixed ventilatory disturbance with a predominantly obstructive component. HAM was diagnosed on the basis of neurological examination and cerebrospinal fluid analysis. A biopsy specimen from the carinal mucosa showed marked T cell infiltration. In these T cells, we detected polyclonal integration of HTLV-1 proviral DNA. Some of the infiltrating T cells showed atypia. In recent times, respiratory diseases other than infiltration of adult T-cell leukemia cells or opportunistic infection have been reported in HTLV-1 carriers and new clinical entities designated as HABA (HTLV-1 associated bronchiolo-alveolar disorder) and HBA (HTLV-1 associated bronchopneumopathy) have been proposed. This case is classified among these new entities, in a broad sense, and is a rare case in that the respiratory disorder is apparently related to UC.We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, chest X-ray films, tomography and CT-scan revealed dilated lumens and thickened airway walls extending from the trachea to subsegmental bronchi. Pulmonary function tests showed hypoxemia and mixed ventilatory disturbance with a predominantly obstructive component. HAM was diagnosed on the basis of neurological examination and cerebrospinal fluid analysis. A biopsy specimen from the carinal mucosa showed marked T cell infiltration. In these T cells, we detected polyclonal integration of HTLV-1 proviral DNA. Some of the infiltrating T cells showed atypia. In recent times, respiratory diseases other than infiltration of adult T-cell leukemia cells or opportunistic infection have been reported in HTLV-1 carriers and new clinical entities designated as HABA (HTLV-1 associated bronchiolo-alveolar disorder) and HBA (HTLV-1 associated bronchopneumopathy) have been proposed. This case is classified among these new entities, in a broad sense, and is a rare case in that the respiratory disorder is apparently related to UC. We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, chest X-ray films, tomography and CT-scan revealed dilated lumens and thickened airway walls extending from the trachea to subsegmental bronchi. Pulmonary function tests showed hypoxemia and mixed ventilatory disturbance with a predominantly obstructive component. HAM was diagnosed on the basis of neurological examination and cerebrospinal fluid analysis. A biopsy specimen from the carinal mucosa showed marked T cell infiltration. In these T cells, we detected polyclonal integration of HTLV-1 proviral DNA. Some of the infiltrating T cells showed atypia. In recent times, respiratory diseases other than infiltration of adult T-cell leukemia cells or opportunistic infection have been reported in HTLV-1 carriers and new clinical entities designated as HABA (HTLV-1 associated bronchiolo-alveolar disorder) and HBA (HTLV-1 associated bronchopneumopathy) have been proposed. This case is classified among these new entities, in a broad sense, and is a rare case in that the respiratory disorder is apparently related to UC. We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, chest X-ray films, tomography and CT-scan revealed dilated lumens and thickened airway walls extending from the trachea to subsegmental bronchi. Pulmonary function tests showed hypoxemia and mixed ventilatory disturbance with a predominantly obstructive component. HAM was diagnosed on the basis of neurological examination and cerebrospinal fluid analysis. A biopsy specimen from the carinal mucosa showed marked T cell infiltration. In these T cells, we detected polyclonal integration of HTLV-1 proviral DNA. Some of the infiltrating T cells showed atypia. In recent times, respiratory diseases other than infiltration of adult T-cell leukemia cells or opportunistic infection have been reported in HTLV-1 carriers and new clinical entities designated as HABA (HTLV-1 associated bronchiolo-alveolar disorder) and HBA (HTLV-1 associated bronchopneumonopathy) have been proposed. This case is classified among these new entities, in a broad sense, and is a rare case in that the respiratory disorder is apparently related to UC. |
| Author | Munakata, Mitsuru Kawakami, Yoshikazu Watanabe, Naomi Fujita, Miri Suzuki, Isamu Yamaguchi, Etsurou Suzuki, Junichi |
| Author_xml | – sequence: 1 fullname: Suzuki, Isamu organization: First Department of Medicine, Hokkaido University School of Medicine – sequence: 1 fullname: Munakata, Mitsuru organization: First Department of Medicine, Hokkaido University School of Medicine – sequence: 1 fullname: Kawakami, Yoshikazu organization: First Department of Medicine, Hokkaido University School of Medicine – sequence: 1 fullname: Watanabe, Naomi organization: First Department of Medicine, Hokkaido University School of Medicine – sequence: 1 fullname: Suzuki, Junichi organization: First Department of Medicine, Hokkaido University School of Medicine – sequence: 1 fullname: Yamaguchi, Etsurou organization: First Department of Medicine, Hokkaido University School of Medicine – sequence: 1 fullname: Fujita, Miri organization: Division of Pathology, Hokkaido University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8041047$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kDtPwzAUhS0EKqWwsyB5Qu2Q4ldiZwzhUaQilhaxRbZzSx2lcYldpP57KlFYzh2-757hXKDTzneA0DUlU0q5yu-apg80z_iUsylP1QkaUqV4IiT9OEVDwglNaCrYOboKoSGEUCkYEWKABooISoQcolWBSx0A-xW-731n1w5s1MEFXFjrN1vdOaix2eNla6HX0X0DLn3r4sEYL8sJ1l2NZ4v5e0JxEYK3TsfDw-seWr_Vcb3H41nxOrlEZyvdBrg63hFaPD0uylkyf3t-KYt50jCexwRAZJSmRDBlJBEmt9QKkRlb10bbXGlGjeSZIHWeS2aFTLmpAayyUhmi-Qjd_tZue_-1gxCrjQsW2lZ34HehklnGaJ6qg3hzFHdmA3W17d1G9_vquMuBP_zyJkT9Cf9c99HZFqq_5SvOKnGMVP1ju9Z9BR3_AaNwfoI |
| ContentType | Journal Article |
| Copyright | by The Japanese Respiratory Society |
| Copyright_xml | – notice: by The Japanese Respiratory Society |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.11389/jjrs1963.32.358 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1883-471X |
| EndPage | 363 |
| ExternalDocumentID | 8041047 article_jjrs1963_32_4_32_4_358_article_char_en |
| Genre | English Abstract Journal Article Case Reports |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS F5P JSF KQ8 RJT CGR CUY CVF ECM EIF MOJWN NPM 7X8 |
| ID | FETCH-LOGICAL-j239t-ee461150428b704b9c1c446bcddbac98a21b73640d9972c4753bdeec8c78b0a3 |
| ISSN | 0301-1542 |
| IngestDate | Fri Jul 11 08:55:26 EDT 2025 Wed Feb 19 01:25:20 EST 2025 Wed Sep 03 06:29:19 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 4 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j239t-ee461150428b704b9c1c446bcddbac98a21b73640d9972c4753bdeec8c78b0a3 |
| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-4 ObjectType-Report-1 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjrs1963/32/4/32_4_358/_article/-char/en |
| PMID | 8041047 |
| PQID | 76621958 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_76621958 pubmed_primary_8041047 jstage_primary_article_jjrs1963_32_4_32_4_358_article_char_en |
| PublicationCentury | 1900 |
| PublicationDate | 1994-Apr |
| PublicationDateYYYYMMDD | 1994-04-01 |
| PublicationDate_xml | – month: 04 year: 1994 text: 1994-Apr |
| PublicationDecade | 1990 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan |
| PublicationTitle | Nihon Kyōbu Shikkan Gakkai zasshi |
| PublicationTitleAlternate | The Japanese journal of thoracic diseases |
| PublicationYear | 1994 |
| Publisher | The Japanese Respiratory Society |
| Publisher_xml | – name: The Japanese Respiratory Society |
| References | 6) 丸山征郎: HTLV-1 associated bronchopneumonopathy (HAB) とその免疫学的側面. 臨床免疫, 21: 570, 1989. 11) Kraft, S. C., Earle, R. H., Roseler, M. & Esterly, J. R.: Unexplained bronchopulmonary disease with inflammatory bowel disease. Arch. Intern. Med., 136: 454, 1976. 2) Maruyama, I., Chihara, J., Sakashita, I., Mizoguchi, A., Mori, S., Usuku, K., Jonosono, M., Tara, M., Matsumoto, M., Niina, S., Sonoda, S., Yashiki, S. & Osame, M.: HTLV-1 associated broncho-pneumonopathy—A new clinical entity? Am. Rev. Respir. Dis., 137: 4, 46, 1988. 9) Isenberg, J. I., Goldstein, H., Korn, A. R., Ozeran, R. S. & Rosen, V.: Pulmonary vasculitis—An uncommon complications of ulcerative colitis. N. Eng. J. Med., 279: 1376, 1968. 13) Desai, S. J., Gephardt, G. N. & Stoller, J. K.: Diffuse panbronchiolitis preceding ulcerative colitis. Chest, 45: 1342, 1989. 1) 木村郁郎: HTLV-1 関連細気管支・肺胞異常症, HTLV-1 associated bronchiolo-alveolar disorder (HABA). 日胸, 47: 283, 1988. 14) Wilcox, P., Miller, R., Miller, G., Heath, J., Nelems, B., Muller, N. & Ostrow, D.: Airway involvement in ulcerative colitis. Chest, 92: 18, 1987. 4) Yoshioka, R., Yamaguchi, K., Yoshinaga, T. & Takatuki, K.: Pulmonary complications in patients with adult T-cell leukemia. Cancer, 55: 2491, 1985. 5) 木村郁郎: HABA (HTLV-1 Associated bronchiolo-alveolar disorder), Med. Immunol., 18: 769, 1989. 16) Higenbottam, T., Cochrane, G. M., Clark, T. J. H., Turner, D., Millis, R. & Seymour, W.: Bronchial disease in ulcerative colitis. Thorax, 35: 581, 1980. 3) Rogers, B. H. G., Clark, L. M. & Kirsner, J. B.: The epidemiologic and demographic characteristics of a computerized file of 1,400 patients. J. Chron. Dis., 24: 743, 1971. 15) 荒木潤, 増本英男, 須山尚史, 原口増穂, 浅井貞宏, 広瀬清人, 早田宏, 原耕平: 潰瘍性大腸炎に対する全結腸切除施行後に気管・気管支病変を呈した1症例. 気管支学, 14: 64, 1992. 10) Mckee, A. L., Rajapaksa, A., Kalish, P. E. & Pitchmoni, C. S.: Severe interstitial fibrosis in a patient with chronic ulcerative colitis. Am. J. Gastroenterol., 78: 86, 1983. 12) Swinburn, C. R., Jackson, G. J., Cobden, I., Ashcroft, T., Morritt, G. N. & Corris, P. A.: Bronchiolitis obliterans organizing pneumonia in a patient with ulcerative colitis. Thorax, 43: 735, 1988. 7) 杉本峯晴, 安藤正幸, 荒木淑郎: HTLV-1 感染における間質性病変. 呼吸, 11: 238-241, 1992. 8) Osame, M., Janssen, R., Kubota, H., Nishitani, H., Igata, A., Nagataki, S., Mori, M., Goto, I., Shimabukuro, H., Khabbaz, R. & Kaplan, J.: Nationwide survey of HTLV-1 associated myelopathy in Japan. Ann. Neurol., 28: 50, 1990. |
| References_xml | – reference: 15) 荒木潤, 増本英男, 須山尚史, 原口増穂, 浅井貞宏, 広瀬清人, 早田宏, 原耕平: 潰瘍性大腸炎に対する全結腸切除施行後に気管・気管支病変を呈した1症例. 気管支学, 14: 64, 1992. – reference: 8) Osame, M., Janssen, R., Kubota, H., Nishitani, H., Igata, A., Nagataki, S., Mori, M., Goto, I., Shimabukuro, H., Khabbaz, R. & Kaplan, J.: Nationwide survey of HTLV-1 associated myelopathy in Japan. Ann. Neurol., 28: 50, 1990. – reference: 10) Mckee, A. L., Rajapaksa, A., Kalish, P. E. & Pitchmoni, C. S.: Severe interstitial fibrosis in a patient with chronic ulcerative colitis. Am. J. Gastroenterol., 78: 86, 1983. – reference: 5) 木村郁郎: HABA (HTLV-1 Associated bronchiolo-alveolar disorder), Med. Immunol., 18: 769, 1989. – reference: 9) Isenberg, J. I., Goldstein, H., Korn, A. R., Ozeran, R. S. & Rosen, V.: Pulmonary vasculitis—An uncommon complications of ulcerative colitis. N. Eng. J. Med., 279: 1376, 1968. – reference: 4) Yoshioka, R., Yamaguchi, K., Yoshinaga, T. & Takatuki, K.: Pulmonary complications in patients with adult T-cell leukemia. Cancer, 55: 2491, 1985. – reference: 16) Higenbottam, T., Cochrane, G. M., Clark, T. J. H., Turner, D., Millis, R. & Seymour, W.: Bronchial disease in ulcerative colitis. Thorax, 35: 581, 1980. – reference: 2) Maruyama, I., Chihara, J., Sakashita, I., Mizoguchi, A., Mori, S., Usuku, K., Jonosono, M., Tara, M., Matsumoto, M., Niina, S., Sonoda, S., Yashiki, S. & Osame, M.: HTLV-1 associated broncho-pneumonopathy—A new clinical entity? Am. Rev. Respir. Dis., 137: 4, 46, 1988. – reference: 11) Kraft, S. C., Earle, R. H., Roseler, M. & Esterly, J. R.: Unexplained bronchopulmonary disease with inflammatory bowel disease. Arch. Intern. Med., 136: 454, 1976. – reference: 14) Wilcox, P., Miller, R., Miller, G., Heath, J., Nelems, B., Muller, N. & Ostrow, D.: Airway involvement in ulcerative colitis. Chest, 92: 18, 1987. – reference: 7) 杉本峯晴, 安藤正幸, 荒木淑郎: HTLV-1 感染における間質性病変. 呼吸, 11: 238-241, 1992. – reference: 13) Desai, S. J., Gephardt, G. N. & Stoller, J. K.: Diffuse panbronchiolitis preceding ulcerative colitis. Chest, 45: 1342, 1989. – reference: 1) 木村郁郎: HTLV-1 関連細気管支・肺胞異常症, HTLV-1 associated bronchiolo-alveolar disorder (HABA). 日胸, 47: 283, 1988. – reference: 3) Rogers, B. H. G., Clark, L. M. & Kirsner, J. B.: The epidemiologic and demographic characteristics of a computerized file of 1,400 patients. J. Chron. Dis., 24: 743, 1971. – reference: 12) Swinburn, C. R., Jackson, G. J., Cobden, I., Ashcroft, T., Morritt, G. N. & Corris, P. A.: Bronchiolitis obliterans organizing pneumonia in a patient with ulcerative colitis. Thorax, 43: 735, 1988. – reference: 6) 丸山征郎: HTLV-1 associated bronchopneumonopathy (HAB) とその免疫学的側面. 臨床免疫, 21: 570, 1989. |
| SSID | ssj0001742044 ssib058493853 ssib005879741 ssib000940322 |
| Score | 1.2343689 |
| Snippet | We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC... |
| SourceID | proquest pubmed jstage |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 358 |
| SubjectTerms | Adult Bronchiectasis Bronchiectasis - etiology Colitis, Ulcerative - complications HTLV-1 associated bronchiolo-alveolar disorder HTLV-1 associated bronchopneumonopathy HTLV-1 associated myelopathy Humans Male Paraparesis, Tropical Spastic - complications Ulcerative colitis |
| Title | A Case of Bronchiectasis Accompanied by Ulcerative Colitis (UC) and HTLV-1 Associated Myelopathy (HAM) |
| URI | https://www.jstage.jst.go.jp/article/jjrs1963/32/4/32_4_358/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/8041047 https://www.proquest.com/docview/76621958 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | The Japanese journal of thoracic diseases, 1994/04/25, Vol.32(4), pp.358-363 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jj9MwFLbKcOGCQDCiwIAPHGaEUrI424FDVYHKDEUCWiinyHacaTo0GTWJ0PTX8lN4jp2lLBIDF6uK68bN-_y2PH9G6BkXDoWATRiJ5EMkhFGDwpozXJMFYZBYMa8TbrN33nRBTpfucjD43qtaqko24rvf7iv5F6nCNZCr3CV7Dcm2PwoX4DPIF1qQMLR_JePx8wlVuXiIpjO-SkF7UckwIs-AkOtc-5eLr1xohu9JXe-mUq0TmRKQifPp_O0nw2pFBYNmV7KUCLzDuhhgOp41GYN1h65TsLPy_Mo--0S5AkjxlDcvflqP_WO1q9QJ2W8Kuqk6OWf0gioPdpaWRbVtu87oN-ja1GO-5MUqvaC7tvMzjMkoE8pA5Ju0y14oGmLSz17szfZDr7hA16z2tCFoIgP8PaW6hdLWQeAYYF2XfXXepUu7XEWtmx3FEa_NvKP06q8WBDw4aULW20Iqp5Fjj9qBe7zcWupR883IsSOiGzeImm65eQ6wegPdtH2_LiQ4ex90WUCf2CZRHGf6_zXv0mEeL36aBXhJa4gZzsWfw6HaLZrfQbd1PIPHah530UBk91AyxhKYOE_wPjBxD5iYXeEOmFgDEx8vJicYQIkVKHEHStyBEh8DJE_uo_nrV_PJ1NAHehhr2wlLQwjiyQgEQl7mm4SF3OKEeIzHMaM8DKhtMd_xiBnL7dycQCjNYiF4wP2AmdQ5RAdZnokHCLu2H3iOnUD8wAh1Q5pY3ONgSxJwianFh-ilelLRpSJtia4nriF62jzgCPStfIkGGM2rIvI9z5YETUN0qJ57ewfJ5GUS_-F_3voRutUtlMfooNxW4ggc35I9qbHzA77jsuA |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Case+of+Bronchiectasis+Accompanied+by+Ulcerative+Colitis+%28UC%29+and+HTLV-1+Associated+Myelopathy+%28HAM%29&rft.jtitle=The+Japanese+journal+of+thoracic+diseases&rft.au=Suzuki%2C+Isamu&rft.au=Munakata%2C+Mitsuru&rft.au=Kawakami%2C+Yoshikazu&rft.au=Watanabe%2C+Naomi&rft.date=1994-04-01&rft.pub=The+Japanese+Respiratory+Society&rft.issn=0301-1542&rft.eissn=1883-471X&rft.volume=32&rft.issue=4&rft.spage=358&rft.epage=363&rft_id=info:doi/10.11389%2Fjjrs1963.32.358&rft.externalDocID=article_jjrs1963_32_4_32_4_358_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0301-1542&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0301-1542&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0301-1542&client=summon |