Alveolar Lymphocyte Proliferation in Sarcoidosis Patients Induced by Propionibacterium acnes
In pulmonary sarcoidosis, interstitial mononuclear infiltrate consists of macrophages and lymphocytes as a characteristic, morphologic feature, and is recognized to represent the initial lesion. Considerable evidence has been reported that alveolar lymphocytes in pulmonary sarcoidosis are activated,...
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| Published in | Nihon Kyōbu Shikkan Gakkai zasshi Vol. 23; no. 4; pp. 413 - 419 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
The Japanese Respiratory Society
01.04.1985
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-1542 1883-471X |
| DOI | 10.11389/jjrs1963.23.413 |
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| Abstract | In pulmonary sarcoidosis, interstitial mononuclear infiltrate consists of macrophages and lymphocytes as a characteristic, morphologic feature, and is recognized to represent the initial lesion. Considerable evidence has been reported that alveolar lymphocytes in pulmonary sarcoidosis are activated, but the activation mechanism is not known. The proliferation of lymphocytes, obtained by bronchoalveolar lavage in vitro incorporation of 3H-thymidine induced Propionibacterium acnes (P. acnes). The mean response rate of alveolar lymphocytes was 2.23±0.89 in nine untreated sarcoidosis patients, 0.85±0.17 in five sarcoidosis patients given prednisolone and 0.78±0.29 in 11 controls. It was significantly enhanced in untreated patients compared to both treated patients (p<0.01) and controls (p<0.001), but there was no significant difference in the response rates between treated patients and controls. The response rate of alveolar lymphocytes in four active patients with sarcoidosis (3.05±0.61) was significantly higher than that in four inactive patients (1.77±0.44) (p<0.05), and that in controls (p<0.001). In sarcoidosis patients, the response rates showed a good correlation with activities of serum lysozyme (r=0.695, p<0.01), and with percentages of lymphocyte in bronchoalveolar lavage fluids (r=0.591, p<0.05). There was a low correlation between angiotensin-converting enzyme activities and response rates (r=0.508, p0.1). The alveolar lymphocyte response rates induced by P. acnes reflect the disease activity of sarcoidosis. Neither peripheral lymphocytes in sarcoidosis patients nor in controls showed a response to P. acnes. It was suggested that alveolar lymphocytes in untreated patients with active sarcoidosis are sensitized with P. acnes, and that activated lymphocytes play a central role in the induction of alveolitis in sarcoidosis patients by P. acnes. |
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| AbstractList | In pulmonary sarcoidosis, interstitial mononuclear infiltrate consists of macrophages and lymphocytes as a characteristic, morphologic feature, and is recognized to represent the initial lesion. Considerable evidence has been reported that alveolar lymphocytes in pulmonary sarcoidosis are activated, but the activation mechanism is not known. The proliferation of lymphocytes, obtained by bronchoalveolar lavage in vitro incorporation of 3H-thymidine induced Propionibacterium acnes (P. acnes). The mean response rate of alveolar lymphocytes was 2.23±0.89 in nine untreated sarcoidosis patients, 0.85±0.17 in five sarcoidosis patients given prednisolone and 0.78±0.29 in 11 controls. It was significantly enhanced in untreated patients compared to both treated patients (p<0.01) and controls (p<0.001), but there was no significant difference in the response rates between treated patients and controls. The response rate of alveolar lymphocytes in four active patients with sarcoidosis (3.05±0.61) was significantly higher than that in four inactive patients (1.77±0.44) (p<0.05), and that in controls (p<0.001). In sarcoidosis patients, the response rates showed a good correlation with activities of serum lysozyme (r=0.695, p<0.01), and with percentages of lymphocyte in bronchoalveolar lavage fluids (r=0.591, p<0.05). There was a low correlation between angiotensin-converting enzyme activities and response rates (r=0.508, p0.1). The alveolar lymphocyte response rates induced by P. acnes reflect the disease activity of sarcoidosis. Neither peripheral lymphocytes in sarcoidosis patients nor in controls showed a response to P. acnes. It was suggested that alveolar lymphocytes in untreated patients with active sarcoidosis are sensitized with P. acnes, and that activated lymphocytes play a central role in the induction of alveolitis in sarcoidosis patients by P. acnes. |
| Author | Ejiri, Togo Kishi, Toshiyuki Nakata, Yasunari Kobayashi, Yozo Kimura, Ikuro Fujita, Michio Ohnoshi, Taisuke |
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| References | 16) Barna, B. P., Deodhar, S. D., Gautam, S., Edinger, M., Chiang, T. & McMahon, T.: Experimental beryllium-induced lung disease. II. Analysis of bronchial lavage cells in strain 2 and 13 guinea pigs. Int. Archs. Allergy Appl. Immun., 73: 49, 1984. 18) James, D. J., Neville, E. & Walker, A.: Immunology of sarcoidosis. Am. J. Med., 59: 388, 1975. 1) 小高稔, 柳川洋: 本症の実態. サルコイドーシス, 日本サルコイドーシス研究協議会編, 東大出版会, 東京, 1978年, 319頁. 4) Hunninghake, G. W., Gadek, J. E., Young, R. C., Kawanami, O., Ferrans, V. J. & Crystal, R. G.: Maintenance of granuloma formation in pulmonary sarcoidosis by T-lymphocytes within the lung. N. Eng. J. Med., 302: 594, 1980. 7) 本間日臣: サルコイドーシスの発生機構に関する研究. 難病の発生機構. 豊倉康夫編, 東京大学出版会, 東京, 1981, 245頁. 2) Rosen, Y., Athanassiades, T. J., Moon, S. & Lyons, H. A.: Nongranulomatous interstitial pneumonitis in sarcoidosis. Relationship to development of epitheloid granulomas. Chest, 74: 122, 1978. 14) Silverstein, E., Pertschuk, L. P. & Friedland, J.: Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas. Proc. Natl. Acad. Sci. U. S. A., 76: 6646, 1979. 6) Pinkston, P., Bitterman, P. B. & Crystal, R. G.: Spontaneous release of interleukin-2 by lung Tlymphocytes in active pulmonary sarcoidosis. N. Engl. J. Med., 308: 793, 1983. 11) Hunninghake, G. W., Keogh, B. A. & Line, B. R. : Pulmonary sarcoidosis. Pathogenesis and therapy : Basic and clinical aspects of granulomatous disease. ed., Baros, D. & Yoshida, T., 1981, p. 275. 10) Razma, A. G., Lynch, J. P., Wilson, B. S., Ward, P. A. & Kunkel, S. L.: Expression of Ia-like (DR) antigen on human alveolar macrophages isolated by bronchoalveolar lavage. Am. Rev. Respir. Dis., 129: 419, 1984. 3) Crystal, R. G., Roberts, W. C., Hunninghake, G. W., Gadek, J. E., Fulmer, J. D. & Line, B. R.: Pulmonary sarcoidosis. A disease characterized and perpetuated by activated lung Tlymphocytes. Ann. Inter. Med., 94: 73, 1981. 15) Kataria, Y. P., LoBuglio, A. F. & Bromberg, P. A.: Sarcoid lymphocytes: Spontaneous transformation and release of macrophage migration inhibition activity. Am. Rev. Respir. Dis., 113: 315, 1976. 17) Halpern, B., Fray, A., Crepin, Y., Platica, O., Corient, A. M., Rabourdin, A., Sparros, L. & Isac, R.: “Immunopotentiation” Ciba Found Symp. Associated Scientific Publishers, Amsterdam, 1973, p. 217. 9) Hunninghake, G. W.: Release of interleukin-1 by alveolar macrophages of patients with active pulmonary sarcoidosis. Am. Rev. Respir. Dis., 129: 569, 1984. 13) Rossman, M. D., Dauber, J. H., Cardillo, M. E. & Daniele, R. P.: Pulmonary sarcoidosis: Correlation of serum angiotensin-converting enzyme with blood and bronchoalveolar lymphocytes. Am. Rev. Respir. Dis., 125: 366, 1982. 8) Ceuppens, J. L., Lacquet, L. M., Marien, G., Demedts, M., Eeckhout, A. & Stevens, E.: Alveolar T-cell subsets in pulmonary sarcoidosis; Correlation with disease activity and effect of steroid treatment. Am. Rev. Respir. Dis., 129: 563, 1984. 12) Pascual, R. S., Gee, J. B. L. & Finch, S. C.: Usefulness of serum lysozyme measurement in diagnosis and evaluation of sarcoidosis. N. Engl. J. Med., 289: 1074, 1973. 5) Hunninghake, G. W. & Crystal, R. G.: Pulmonary sarcoidosis. A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N. Engl. J. Med., 305: 429, 1981. |
| References_xml | – reference: 3) Crystal, R. G., Roberts, W. C., Hunninghake, G. W., Gadek, J. E., Fulmer, J. D. & Line, B. R.: Pulmonary sarcoidosis. A disease characterized and perpetuated by activated lung Tlymphocytes. Ann. Inter. Med., 94: 73, 1981. – reference: 17) Halpern, B., Fray, A., Crepin, Y., Platica, O., Corient, A. M., Rabourdin, A., Sparros, L. & Isac, R.: “Immunopotentiation” Ciba Found Symp. Associated Scientific Publishers, Amsterdam, 1973, p. 217. – reference: 8) Ceuppens, J. L., Lacquet, L. M., Marien, G., Demedts, M., Eeckhout, A. & Stevens, E.: Alveolar T-cell subsets in pulmonary sarcoidosis; Correlation with disease activity and effect of steroid treatment. Am. Rev. Respir. Dis., 129: 563, 1984. – reference: 5) Hunninghake, G. W. & Crystal, R. G.: Pulmonary sarcoidosis. A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N. Engl. J. Med., 305: 429, 1981. – reference: 7) 本間日臣: サルコイドーシスの発生機構に関する研究. 難病の発生機構. 豊倉康夫編, 東京大学出版会, 東京, 1981, 245頁. – reference: 14) Silverstein, E., Pertschuk, L. P. & Friedland, J.: Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas. Proc. Natl. Acad. Sci. U. S. A., 76: 6646, 1979. – reference: 4) Hunninghake, G. W., Gadek, J. E., Young, R. C., Kawanami, O., Ferrans, V. J. & Crystal, R. G.: Maintenance of granuloma formation in pulmonary sarcoidosis by T-lymphocytes within the lung. N. Eng. J. Med., 302: 594, 1980. – reference: 12) Pascual, R. S., Gee, J. B. L. & Finch, S. C.: Usefulness of serum lysozyme measurement in diagnosis and evaluation of sarcoidosis. N. Engl. J. Med., 289: 1074, 1973. – reference: 1) 小高稔, 柳川洋: 本症の実態. サルコイドーシス, 日本サルコイドーシス研究協議会編, 東大出版会, 東京, 1978年, 319頁. – reference: 2) Rosen, Y., Athanassiades, T. J., Moon, S. & Lyons, H. A.: Nongranulomatous interstitial pneumonitis in sarcoidosis. Relationship to development of epitheloid granulomas. Chest, 74: 122, 1978. – reference: 6) Pinkston, P., Bitterman, P. B. & Crystal, R. G.: Spontaneous release of interleukin-2 by lung Tlymphocytes in active pulmonary sarcoidosis. N. Engl. J. Med., 308: 793, 1983. – reference: 16) Barna, B. P., Deodhar, S. D., Gautam, S., Edinger, M., Chiang, T. & McMahon, T.: Experimental beryllium-induced lung disease. II. Analysis of bronchial lavage cells in strain 2 and 13 guinea pigs. Int. Archs. Allergy Appl. Immun., 73: 49, 1984. – reference: 9) Hunninghake, G. W.: Release of interleukin-1 by alveolar macrophages of patients with active pulmonary sarcoidosis. Am. Rev. Respir. Dis., 129: 569, 1984. – reference: 13) Rossman, M. D., Dauber, J. H., Cardillo, M. E. & Daniele, R. P.: Pulmonary sarcoidosis: Correlation of serum angiotensin-converting enzyme with blood and bronchoalveolar lymphocytes. Am. Rev. Respir. Dis., 125: 366, 1982. – reference: 11) Hunninghake, G. W., Keogh, B. A. & Line, B. R. : Pulmonary sarcoidosis. Pathogenesis and therapy : Basic and clinical aspects of granulomatous disease. ed., Baros, D. & Yoshida, T., 1981, p. 275. – reference: 15) Kataria, Y. P., LoBuglio, A. F. & Bromberg, P. A.: Sarcoid lymphocytes: Spontaneous transformation and release of macrophage migration inhibition activity. Am. Rev. Respir. Dis., 113: 315, 1976. – reference: 18) James, D. J., Neville, E. & Walker, A.: Immunology of sarcoidosis. Am. J. Med., 59: 388, 1975. – reference: 10) Razma, A. G., Lynch, J. P., Wilson, B. S., Ward, P. A. & Kunkel, S. L.: Expression of Ia-like (DR) antigen on human alveolar macrophages isolated by bronchoalveolar lavage. Am. Rev. Respir. Dis., 129: 419, 1984. |
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| SubjectTerms | Adult Aged Alveolar lymphocyte Alveolitis Bronchoalveolar laveage Female Humans Lymphocyte Activation Lymphocyte blastogenesis Male Middle Aged Propionibacterium acnes - immunology Pulmonary Alveoli - cytology Sarcoidosis Sarcoidosis - immunology |
| Title | Alveolar Lymphocyte Proliferation in Sarcoidosis Patients Induced by Propionibacterium acnes |
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