メチシリン感受性, 中等度耐性および高度耐性黄色ブドウ球菌に対する16抗菌剤の耐性頻度の比較
臨床より分離された黄色ブドウ球菌351株に対する16抗菌剤の感受性を検討した。それらの株をmethicillinの感受性分布により, 感受性株 (MSSA), 中等度耐性株 (L-MRSA) および高度耐性株 (H-MRSA) の3群に分類したところ, β-lactams, fluoroquinolonesおよびerythromycinのH-MRSAに対する耐性株の分離頻度は, L-MRSA群のそれより有意に高いことが示されたが, その他の薬剤では有意な差は認められなかった。...
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| Published in | CHEMOTHERAPY Vol. 39; no. 12; pp. 1148 - 1151 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本化学療法学会
1991
|
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.39.1148 |
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| Abstract | 臨床より分離された黄色ブドウ球菌351株に対する16抗菌剤の感受性を検討した。それらの株をmethicillinの感受性分布により, 感受性株 (MSSA), 中等度耐性株 (L-MRSA) および高度耐性株 (H-MRSA) の3群に分類したところ, β-lactams, fluoroquinolonesおよびerythromycinのH-MRSAに対する耐性株の分離頻度は, L-MRSA群のそれより有意に高いことが示されたが, その他の薬剤では有意な差は認められなかった。 |
|---|---|
| AbstractList | 臨床より分離された黄色ブドウ球菌351株に対する16抗菌剤の感受性を検討した。それらの株をmethicillinの感受性分布により, 感受性株 (MSSA), 中等度耐性株 (L-MRSA) および高度耐性株 (H-MRSA) の3群に分類したところ, β-lactams, fluoroquinolonesおよびerythromycinのH-MRSAに対する耐性株の分離頻度は, L-MRSA群のそれより有意に高いことが示されたが, その他の薬剤では有意な差は認められなかった。 |
| Author | 渡邊, 正人 吉田, 益史 三橋, 進 村谷, 哲郎 |
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| References | 12) Qoronfleh M W, Wilkinson B J: Effects of growth of methicillin-resistant and-susceptible Staphylococcus aureus in the presence of β-lactams on peptidoglycan structure and susceptibility to lytic enzymes. Antimicrob Agent Chemother 29: 250-257, 1986 6) Kojima K, Inoue M, Mitsuhashi S: In vitro activity of AT-4140 against quinolone-and methicillin-resistant Staphylococcus aureus. Antimicrob Agent Chemother 34: 1123-1127, 1990 5) Daum T E, Schaberg D R, Terpenning M S, Sottile W S, Kauffman C A: Increasing resistance of Staphylococcus aureus to ciprofloxacin. Antimicrob Agents Chemother 34: 1862-1863, 1990 3) Lyon B R, Skurray R: Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiological Reviews 51: 88-134, 1987 7) Murakami K, Nomura K, Doi M, Yoshida T: Production of low-affinity penicillin-binding protein by low-and high-resistance groups of methicillin-resistant Staphylococcus aureus. Antimicrob Agent Chemother 31: 1307-1311, 1987 10) Inoue M, Okubo T, Okamoto R, Hashimoto H: 64 th Japanese Society for Bacteriology: Abstract No.D-II-13, 1991 9) Utsui Y, Yokota T: Role of an altered penicillin-binding protein in methicillin-and cephem-resistant Staphylococcus aureus. Antimicrob Agent Chemother 28: 397-403, 1985 13) Yoshida S, Kojima T, Inoue M, Mitsuhashi S: Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus. Antimicrob Agent Chemother 35: 368-370, 1991 16) Novick P R, Murphy E: MLS-resistance determinants in Staphylococcus aureus and their molecular evolution. J Antimicrob Chemother16: suppl. A, 101-110, 1985 15) Yoshida S, Wakebe H, Nakanishi N, Kojima T, Inoue M, Mitsuhashi S: 39th Japanese Society for Chemotherapy, Abstract No.187, 1991 2) Goto H, Goto M, Oka S, Shimada K, Shimizu K, Goto S, Ueno K, Hara K: The prevalence of multiply resistant Staphylococcus aureus in Japan during 1986 and 1988. Chemotherapy 37: 1334-1341, 1989 11) Bruns W, Keppeler H, Baucks R: Suppression of intrinsic resistance to penicillins in Staphylococcus aureus by polidocanol, a dodecyl polyethyleneoxid ether. Antimicrob Agent Chemother 27: 632-639, 1985 1) Deguchi K, Yokota N, Koguchi M, Nakane Y, Fukushima Y, Fukayama S. Ishihara R, Oda S. Tanaka S, Sato K: Yearly changes in resistance to new quinolones and multiple drug-regimens in clinical isolates. Chemotherapy 38: 1012-1019, 1990 8) Ubukata K, Yamashita N, Konno M: Occurrence of a β-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci. Antimicrob Agent Chemother 27: 851-857, 1985 14) Okuda J, Okamoto S, Takahata M, Nishino T: 39th Japanese Society for Chemotherapy, Abstract No.186, 1991 4) Mitsuhashi N, Mizuno M: Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) strains and treatment of in-patients infected with MRSA. Chemotherapy 38: 927-932, 1990 |
| References_xml | – reference: 11) Bruns W, Keppeler H, Baucks R: Suppression of intrinsic resistance to penicillins in Staphylococcus aureus by polidocanol, a dodecyl polyethyleneoxid ether. Antimicrob Agent Chemother 27: 632-639, 1985 – reference: 12) Qoronfleh M W, Wilkinson B J: Effects of growth of methicillin-resistant and-susceptible Staphylococcus aureus in the presence of β-lactams on peptidoglycan structure and susceptibility to lytic enzymes. Antimicrob Agent Chemother 29: 250-257, 1986 – reference: 9) Utsui Y, Yokota T: Role of an altered penicillin-binding protein in methicillin-and cephem-resistant Staphylococcus aureus. Antimicrob Agent Chemother 28: 397-403, 1985 – reference: 7) Murakami K, Nomura K, Doi M, Yoshida T: Production of low-affinity penicillin-binding protein by low-and high-resistance groups of methicillin-resistant Staphylococcus aureus. Antimicrob Agent Chemother 31: 1307-1311, 1987 – reference: 16) Novick P R, Murphy E: MLS-resistance determinants in Staphylococcus aureus and their molecular evolution. J Antimicrob Chemother16: suppl. A, 101-110, 1985 – reference: 6) Kojima K, Inoue M, Mitsuhashi S: In vitro activity of AT-4140 against quinolone-and methicillin-resistant Staphylococcus aureus. Antimicrob Agent Chemother 34: 1123-1127, 1990 – reference: 14) Okuda J, Okamoto S, Takahata M, Nishino T: 39th Japanese Society for Chemotherapy, Abstract No.186, 1991 – reference: 2) Goto H, Goto M, Oka S, Shimada K, Shimizu K, Goto S, Ueno K, Hara K: The prevalence of multiply resistant Staphylococcus aureus in Japan during 1986 and 1988. Chemotherapy 37: 1334-1341, 1989 – reference: 8) Ubukata K, Yamashita N, Konno M: Occurrence of a β-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci. Antimicrob Agent Chemother 27: 851-857, 1985 – reference: 15) Yoshida S, Wakebe H, Nakanishi N, Kojima T, Inoue M, Mitsuhashi S: 39th Japanese Society for Chemotherapy, Abstract No.187, 1991 – reference: 1) Deguchi K, Yokota N, Koguchi M, Nakane Y, Fukushima Y, Fukayama S. Ishihara R, Oda S. Tanaka S, Sato K: Yearly changes in resistance to new quinolones and multiple drug-regimens in clinical isolates. Chemotherapy 38: 1012-1019, 1990 – reference: 10) Inoue M, Okubo T, Okamoto R, Hashimoto H: 64 th Japanese Society for Bacteriology: Abstract No.D-II-13, 1991 – reference: 13) Yoshida S, Kojima T, Inoue M, Mitsuhashi S: Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus. Antimicrob Agent Chemother 35: 368-370, 1991 – reference: 5) Daum T E, Schaberg D R, Terpenning M S, Sottile W S, Kauffman C A: Increasing resistance of Staphylococcus aureus to ciprofloxacin. Antimicrob Agents Chemother 34: 1862-1863, 1990 – reference: 3) Lyon B R, Skurray R: Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiological Reviews 51: 88-134, 1987 – reference: 4) Mitsuhashi N, Mizuno M: Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) strains and treatment of in-patients infected with MRSA. Chemotherapy 38: 927-932, 1990 |
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| Snippet | 臨床より分離された黄色ブドウ球菌351株に対する16抗菌剤の感受性を検討した。それらの株をmethicillinの感受性分布により, 感受性株 (MSSA), 中等度耐性株 (L-MRSA) および高度耐性株 (H-MRSA) の3群に分類したところ, β-lactams,... |
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| Title | メチシリン感受性, 中等度耐性および高度耐性黄色ブドウ球菌に対する16抗菌剤の耐性頻度の比較 |
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