PDGF-alpha receptor expression following hypoxic-ischemic injury in the neonatal rat brain

• Published in: Kobe journal of the medical sciences Vol. 50; no. 1-2; pp. 21 - 30
• Main Authors: Morioka, Ichiro, Tsuneishi, Syuichi, Takada, Satoshi, Matsuo, Masafumi
• Format: Journal Article
• Language: English
• Published: Japan 01.01.2004
• Subjects: Animals; Animals, Newborn - metabolism; Cerebral Cortex - chemistry; Cerebral Cortex - growth & development; Gene Expression; Hypoxia-Ischemia, Brain - metabolism; Immunohistochemistry; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor alpha - analysis; Receptor, Platelet-Derived Growth Factor alpha - genetics; RNA, Messenger - analysis

Hypoxia-ischemia (HI) causes injury to oligodendrocytes (OLs), cells which create the myelin sheath in the developing brain. OLs pass successively through progenitor and immature stages during differentiation into mature OLs. Only the OLs in the progenitors stage can express the platelet-derived gro...