Prostaglandin E2 Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Activity and Airway Surface Liquid Volume Requires Gap Junctional Communication

• Published in: American journal of respiratory cell and molecular biology Vol. 44; no. 1; pp. 74 - 82
• Main Authors: Scheckenbach, K. E. Ludwig, Losa, Davide, Dudez, Tecla, Bacchetta, Marc, O'Grady, Scott, Crespin, Sophie, Chanson, Marc
• Format: Journal Article
• Language: English
• Published: American Thoracic Society 01.01.2011

Stimulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by protease-activated receptors (PARs) at the basolateral membranes and by adenosine receptors (ADO-Rs) at the apical membrane maintain airway surface liquid (ASL) volume, which is required to ensure hydrated and clearable...