時間運動学を基盤とした運動による抗肥満効果の解明 −メラトニンの役割に着目して
運動は，肥満を改善し生活習慣病を予防する．松果体ホルモンであるメラトニンは強力な抗酸化能を有し，抗肥満効果が期待されている．本研究では，運動効果の最大化を目指し，運動による抗肥満効果に及ぼすメラトニンの影響を検討した．実験にはWistar雄性ラットを使用し，トレッドミルを用いた9週間の運動トレーニング実験と回転輪付きケージを用いた11日間の自発運動実験を実施した．介入終了後，採取した血液および鼠蹊部脂肪組織から血清および成熟脂肪細胞を調整し，アディポカインの網羅的解析および脂肪細胞の機能およびベージュ化に関連する項目を評価した．その結果，運動とメラトニンの併用は体重および脂肪組織重量を顕著に減...
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| Published in | デサントスポーツ科学 Vol. 43; pp. 21 - 33 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益財団法人 石本記念デサントスポーツ科学振興財団
20.06.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0285-5739 2758-4429 |
| DOI | 10.57488/descente.43.0_21 |
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| Abstract | 運動は，肥満を改善し生活習慣病を予防する．松果体ホルモンであるメラトニンは強力な抗酸化能を有し，抗肥満効果が期待されている．本研究では，運動効果の最大化を目指し，運動による抗肥満効果に及ぼすメラトニンの影響を検討した．実験にはWistar雄性ラットを使用し，トレッドミルを用いた9週間の運動トレーニング実験と回転輪付きケージを用いた11日間の自発運動実験を実施した．介入終了後，採取した血液および鼠蹊部脂肪組織から血清および成熟脂肪細胞を調整し，アディポカインの網羅的解析および脂肪細胞の機能およびベージュ化に関連する項目を評価した．その結果，運動とメラトニンの併用は体重および脂肪組織重量を顕著に減少させ，さらに炎症性のアディポカイン分泌を減少させた．また血中の抗酸化能を亢進させ，ベージュ脂肪細胞のマーカータンパク質の発現量も増加させた．これらの結果は，メラトニンが運動による抗肥満効果を増強する可能性を示唆している． |
|---|---|
| AbstractList | 運動は，肥満を改善し生活習慣病を予防する．松果体ホルモンであるメラトニンは強力な抗酸化能を有し，抗肥満効果が期待されている．本研究では，運動効果の最大化を目指し，運動による抗肥満効果に及ぼすメラトニンの影響を検討した．実験にはWistar雄性ラットを使用し，トレッドミルを用いた9週間の運動トレーニング実験と回転輪付きケージを用いた11日間の自発運動実験を実施した．介入終了後，採取した血液および鼠蹊部脂肪組織から血清および成熟脂肪細胞を調整し，アディポカインの網羅的解析および脂肪細胞の機能およびベージュ化に関連する項目を評価した．その結果，運動とメラトニンの併用は体重および脂肪組織重量を顕著に減少させ，さらに炎症性のアディポカイン分泌を減少させた．また血中の抗酸化能を亢進させ，ベージュ脂肪細胞のマーカータンパク質の発現量も増加させた．これらの結果は，メラトニンが運動による抗肥満効果を増強する可能性を示唆している． |
| Author | 大澤, 晴太 加藤, 久詞 |
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Rep. 14: 27-42 (2017 7) Borges-Silva C.N., Alonso-Vale M.I.C., Franzói-De-Moraes S.M., Takada J., Peres S.B., Andreotti S., Skorupa A.L., Cipolla-Neto J., Pithon-Curi T.C., Lima F.B., Pinealectomy impairs adipose tissue adaptability to exercise in rats, J Pineal Res, 38: 278-283 (2005 1) Aronne L.J., Epidemiology, morbidity, and treatment of overweight and obesity, J Clin Psychiatry, 62 Suppl 23: 13-22 (2001 8) Stanford K.I., Middelbeek R.J.W., Townsend K.L., Lee M.Y., Takahashi H., So K., Hitchcox K.M., Markan K.R., Hellbach K., Hirshman M.F., Tseng Y.H., Goodyear L.J., A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis, Diabetes, 64: 2002-2014 (2015 19) Jiménez-Aranda A., Fernández-Vázquez G., Campos D., Tassi M., Velasco-Perez L., Tan D.X., Reiter R.J., Agil A., Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats, J Pineal Res, 55: 416-423 (2013 5) Kato H., Ogasawara J., Takakura H., Shirato K., Sakurai T., Kizaki T., Izawa T., Exercise Ttraining-Eenhanced Llipolytic Ppotency to Ccatecholamine Ddepends on the Ttime of the Dday, Int J Mol Sci, 21: 6920 (2020 24) Tanaka T., Yamamoto J., Iwasaki S., Asaba H., Hamura H., Ikeda Y., Watanabe M., Magoori K., Ioka R.X., Tachibana K., Watanabe Y., Uchiyama Y., Sumi K., Iguchi H., Ito S., Doi T., Hamakubo T., Naito M., Auwerx J., Yanagisawa M., Kodama T., Sakai J., Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome, Proc Natl Acad Sci USA, 100: 15921-15929 (2003 25) Kruk J., Aboul-Enein B.H., Duchnik E., Exercise-induced oxidative stress and melatonin supplementation: current evidence, J Physiol Sci, 71: 27 (2021 17) Stanford K.I., Middelbeek R.J.W., Goodyea L.J., Exercise Eeffects on Wwhite Aadipose Ttissue: Bbeiging and Mmetabolic Aadaptations, Diabetes, 64: 2361-2368 (2015 21) Rahman M.M., Kwon H.S., Kim M.J., Go H.K., Oak M.H., Kim D.H., Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus, Biomed Pharmacother, 92: 606-614 (2017 15) Wu J., Boström P., Sparks L.M., Ye L., Choi J.H., Giang A.H., Khandekar M., Virtanen K.A., Nuutila P., Schaart G., Huang K., Tu H., van Marken Lichtenbelt W.D., Hoeks J., Enerbäck S., Schrauwen P., Spiegelman B.M., Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human, Cell, 150: 366-376 (2012 2) Bassuk S.S., Manson J.E., Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease, J Appl Physiol, 99: 1193-1204 (2005 16) Shinoda K., Luijten I.H., Hasegawa Y., Hong H., Sonne S.B., Kim M., Xue R., Chondronikola M., Cypess A.M., Tseng Y.H., Nedergaard J., Sidossis L.S., Kajimura S., Genetic and functional characterization of clonally derived adult human brown adipocytes, Nat Med, 21: 389-394 (2015 23) Kim K.H., Kim S.H., Min Y.K., Yang H.M., Lee J.B., Lee M.S., Acute Eexercise Iinduces FGF21 Eexpression in Mmice and in Hhealthy Hhumans, PLoS One, 8: e63517 (2013 4) Panda S., Circadian physiology of metabolism, Science, 354: 1008-1015 (2016 Nedergaard J., Bengtsson T., Cannon B., Unexpected evidence for active brown adipose tissue in adult humans, Am J physiol Endocrinol Metab, 293: E444-452 (2007) 3) Sakurai T., Ogasawara J., Kizaki T., Sato S., Ishibashi Y., Takahashi M., Kobayashi O., Oh-ishi S., Nagasawa J., Takahashi K., Ishida H., Izawa T., Ohno H., The Eeffects of Eexercise Ttraining on Oobesity-Iinduced Ddysregulated Eexpression of Aadipokines in Wwhite Aadipose Ttissue, Int J Endocorinol, 2013: 801743 (2013 6) Karamitri A. and Jockers R., Melatonin in type 2 diabetes mellitus and obesity, Nat Rev Endocrinol, 15: 105-125 (2019 22) Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick, J.T., Hawkins E.D., Wroblewski V.J., Li D.S., Mehrbod F., Jaskunas S.R., Shanafelt A.B., FGF-21 as a novel metabolic regulator, J Clin Invest, 115: 1627–1635 (2005 14) Sakamoto T., Nitta T., Maruno K., Yeh Y.S., Kuwata H., Tomita K., Goto T., Takahashi N., Kawada T., Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice, Am J Physiol Endocrinol Metab, 310: E676-E687 (2016 11) Bourin P., Bunnell B.A., Casteilla L., Dominici M., Katz A.J., March K.L., Redl H., Rubin J.P., Yoshimura K., Gimble J.M., Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT), Cytotherapy, 15: 641-648 (2013 20) During M.J., Liu X., Huang W., Magee D., Slater A., McMurphy T., Wang C., Cao L., Adipose VEGF Llinks the Wwhite-to-Bbrown Ffat Sswitch Wwith Eenvironmental, Ggenetic, and Ppharmacological Sstimuli in Mmale Mmice, Endocrinology, 156: 2059-2073 (2015 13) Sidossis L., Kajimura S., Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis, J Clin Invest, 125: 478-486 (2015 |
| References_xml | – reference: 15) Wu J., Boström P., Sparks L.M., Ye L., Choi J.H., Giang A.H., Khandekar M., Virtanen K.A., Nuutila P., Schaart G., Huang K., Tu H., van Marken Lichtenbelt W.D., Hoeks J., Enerbäck S., Schrauwen P., Spiegelman B.M., Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human, Cell, 150: 366-376 (2012) – reference: 1) Aronne L.J., Epidemiology, morbidity, and treatment of overweight and obesity, J Clin Psychiatry, 62 Suppl 23: 13-22 (2001) – reference: 5) Kato H., Ogasawara J., Takakura H., Shirato K., Sakurai T., Kizaki T., Izawa T., Exercise Ttraining-Eenhanced Llipolytic Ppotency to Ccatecholamine Ddepends on the Ttime of the Dday, Int J Mol Sci, 21: 6920 (2020) – reference: 16) Shinoda K., Luijten I.H., Hasegawa Y., Hong H., Sonne S.B., Kim M., Xue R., Chondronikola M., Cypess A.M., Tseng Y.H., Nedergaard J., Sidossis L.S., Kajimura S., Genetic and functional characterization of clonally derived adult human brown adipocytes, Nat Med, 21: 389-394 (2015) – reference: 14) Sakamoto T., Nitta T., Maruno K., Yeh Y.S., Kuwata H., Tomita K., Goto T., Takahashi N., Kawada T., Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice, Am J Physiol Endocrinol Metab, 310: E676-E687 (2016) – reference: 8) Stanford K.I., Middelbeek R.J.W., Townsend K.L., Lee M.Y., Takahashi H., So K., Hitchcox K.M., Markan K.R., Hellbach K., Hirshman M.F., Tseng Y.H., Goodyear L.J., A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis, Diabetes, 64: 2002-2014 (2015) – reference: 20) During M.J., Liu X., Huang W., Magee D., Slater A., McMurphy T., Wang C., Cao L., Adipose VEGF Llinks the Wwhite-to-Bbrown Ffat Sswitch Wwith Eenvironmental, Ggenetic, and Ppharmacological Sstimuli in Mmale Mmice, Endocrinology, 156: 2059-2073 (2015) – reference: 3) Sakurai T., Ogasawara J., Kizaki T., Sato S., Ishibashi Y., Takahashi M., Kobayashi O., Oh-ishi S., Nagasawa J., Takahashi K., Ishida H., Izawa T., Ohno H., The Eeffects of Eexercise Ttraining on Oobesity-Iinduced Ddysregulated Eexpression of Aadipokines in Wwhite Aadipose Ttissue, Int J Endocorinol, 2013: 801743 (2013) – reference: 25) Kruk J., Aboul-Enein B.H., Duchnik E., Exercise-induced oxidative stress and melatonin supplementation: current evidence, J Physiol Sci, 71: 27 (2021) – reference: 9) Pasquini A., Luchetti E., Marchetti V., Cardini G., Iorio E.L. Analytical performances of d-ROMs test and BAP test in canine plasma. Definition of the normal range in healthy Labrador dogs, Vet Res Commun, 32: 137-143 (2008) – reference: 23) Kim K.H., Kim S.H., Min Y.K., Yang H.M., Lee J.B., Lee M.S., Acute Eexercise Iinduces FGF21 Eexpression in Mmice and in Hhealthy Hhumans, PLoS One, 8: e63517 (2013) – reference: 13) Sidossis L., Kajimura S., Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis, J Clin Invest, 125: 478-486 (2015) – reference: 2) Bassuk S.S., Manson J.E., Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease, J Appl Physiol, 99: 1193-1204 (2005) – reference: 11) Bourin P., Bunnell B.A., Casteilla L., Dominici M., Katz A.J., March K.L., Redl H., Rubin J.P., Yoshimura K., Gimble J.M., Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT), Cytotherapy, 15: 641-648 (2013) – reference: 4) Panda S., Circadian physiology of metabolism, Science, 354: 1008-1015 (2016) – reference: 6) Karamitri A. and Jockers R., Melatonin in type 2 diabetes mellitus and obesity, Nat Rev Endocrinol, 15: 105-125 (2019) – reference: 22) Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick, J.T., Hawkins E.D., Wroblewski V.J., Li D.S., Mehrbod F., Jaskunas S.R., Shanafelt A.B., FGF-21 as a novel metabolic regulator, J Clin Invest, 115: 1627–1635 (2005) – reference: 21) Rahman M.M., Kwon H.S., Kim M.J., Go H.K., Oak M.H., Kim D.H., Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus, Biomed Pharmacother, 92: 606-614 (2017) – reference: 7) Borges-Silva C.N., Alonso-Vale M.I.C., Franzói-De-Moraes S.M., Takada J., Peres S.B., Andreotti S., Skorupa A.L., Cipolla-Neto J., Pithon-Curi T.C., Lima F.B., Pinealectomy impairs adipose tissue adaptability to exercise in rats, J Pineal Res, 38: 278-283 (2005) – reference: Nedergaard J., Bengtsson T., Cannon B., Unexpected evidence for active brown adipose tissue in adult humans, Am J physiol Endocrinol Metab, 293: E444-452 (2007) – reference: 24) Tanaka T., Yamamoto J., Iwasaki S., Asaba H., Hamura H., Ikeda Y., Watanabe M., Magoori K., Ioka R.X., Tachibana K., Watanabe Y., Uchiyama Y., Sumi K., Iguchi H., Ito S., Doi T., Hamakubo T., Naito M., Auwerx J., Yanagisawa M., Kodama T., Sakai J., Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome, Proc Natl Acad Sci USA, 100: 15921-15929 (2003) – reference: 19) Jiménez-Aranda A., Fernández-Vázquez G., Campos D., Tassi M., Velasco-Perez L., Tan D.X., Reiter R.J., Agil A., Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats, J Pineal Res, 55: 416-423 (2013) – reference: 18) Lehnig A.C., Dewal R.S., Baer L.A., Kitching K.M., Munoz V.R., Arts P.J., Sindeldecker D.A., May F.J., Lauritzen H.P.M.M., Goodyear L.J., Stanford K.I., Exercise Ttraining Iinduces Ddepot-Sspecific Aadaptations to Wwhite and Bbrown Aadipose Ttissue, iScience, 11: 425-439 (2019) – reference: 10) Sarantopoulos C.N., Banyard D., Ziegler M.E., Sun B., Shaterian A., Widgerow A.D., Elucidating the Ppreadipocyte and Iits Rrole in Aadipocyte Fformation: Aa Ccomprehensive Rreview, Stem Cell Rev. Rep. 14: 27-42 (2017) – reference: 17) Stanford K.I., Middelbeek R.J.W., Goodyea L.J., Exercise Eeffects on Wwhite Aadipose Ttissue: Bbeiging and Mmetabolic Aadaptations, Diabetes, 64: 2361-2368 (2015) |
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| Title | 時間運動学を基盤とした運動による抗肥満効果の解明 −メラトニンの役割に着目して |
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