FUNDAMENTAL AND CLINICAL STUDIES OF 6059-S IN SURGICAL FIELD
Biliary concentrations of 6059-S after intravenous injection of 1 g were assayed in 3 cases, and high peak level of 139μg/ml in mean value was observed after 2 hours. 6059-S was administered to 12 cases of infection (11 cases of superficial soft tissue infection and one case of perforative peritonit...
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| Published in | CHEMOTHERAPY Vol. 28; no. Supplement7; pp. 636 - 639 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
01.01.1980
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| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.28.Supplement7_636 |
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| Abstract | Biliary concentrations of 6059-S after intravenous injection of 1 g were assayed in 3 cases, and high peak level of 139μg/ml in mean value was observed after 2 hours. 6059-S was administered to 12 cases of infection (11 cases of superficial soft tissue infection and one case of perforative peritonitis) and one case of prophylactic use for burn.The clinical response of the drug in 12 cases of infection was excellent in 6 cases, good in 3 cases and fair in 4 cases with 75.0% of efficacy, and the result of prophylactic use was effective. Bacteriologically, all causative organisms were eradicated in 4 cases of S.aureus, one case of S.epidermidis and one case of E.coli mixed with Bacteroides. No side effect nor adverse reaction on blood and blood chemistry was observed in these cases. |
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| AbstractList | Biliary concentrations of 6059-S after intravenous injection of 1 g were assayed in 3 cases, and high peak level of 139μg/ml in mean value was observed after 2 hours. 6059-S was administered to 12 cases of infection (11 cases of superficial soft tissue infection and one case of perforative peritonitis) and one case of prophylactic use for burn.The clinical response of the drug in 12 cases of infection was excellent in 6 cases, good in 3 cases and fair in 4 cases with 75.0% of efficacy, and the result of prophylactic use was effective. Bacteriologically, all causative organisms were eradicated in 4 cases of S.aureus, one case of S.epidermidis and one case of E.coli mixed with Bacteroides. No side effect nor adverse reaction on blood and blood chemistry was observed in these cases. |
| Author | TANAKA, TOYOHARU TAKENAKA, NOBUO ISHIDA, MOTOHIKO KATOH, SHIGETSUGU |
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| References | 1) NARISADA, M.; et al.: Synthetic studies on P-lactam antibiotics. Part 10. Synthesis of 713-(2-carboxy-2-(4-hydraxyphenyl) acetamido)-7a-methoxy-3-(((1-methyl-1/1-tertazol-5-yl) thio) methyl)-1-oxa-1-dethia-3-cephm-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems. J. Med. Chem. 22: 757-759, 1979 2) WISE, R.; J. M. ANDREWS & K. A. BEDFORD: LY127935, a novel oxa-β-lactam: anin vitro comparison withother P-lactam antibiotics. Antlmicr. Agents & Chemoth. 16: 341-445, 1979 3) NEU, H. C.; N. ASWAPOKRE, K. P. Fu & P. ASWAPOKEB: Antibacterial activity of a now 1 oxa cephalosporin compared with that of other β-lactam compounds. Antimicr. Agents & Chemoth. 16: 141-149, 1979 5) FU, K. P. & H. C. Nitu: The comparative β-lactamase resistance and inhibitory activity of 1-oxa cephalosporin, cefoxitin and cefotaxime. J. Antibiot. 32: 909-914, 1979 4) BARZA, M.; F. P. TALLY, N. V. JACOBUS & S. L. GORBACH: In vitro activity of LY127935. Antimicr. Agents & Chemoth. 16: 287-492, 1979 |
| References_xml | – reference: 4) BARZA, M.; F. P. TALLY, N. V. JACOBUS & S. L. GORBACH: In vitro activity of LY127935. Antimicr. Agents & Chemoth. 16: 287-492, 1979 – reference: 1) NARISADA, M.; et al.: Synthetic studies on P-lactam antibiotics. Part 10. Synthesis of 713-(2-carboxy-2-(4-hydraxyphenyl) acetamido)-7a-methoxy-3-(((1-methyl-1/1-tertazol-5-yl) thio) methyl)-1-oxa-1-dethia-3-cephm-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems. J. Med. Chem. 22: 757-759, 1979 – reference: 2) WISE, R.; J. M. ANDREWS & K. A. BEDFORD: LY127935, a novel oxa-β-lactam: anin vitro comparison withother P-lactam antibiotics. Antlmicr. Agents & Chemoth. 16: 341-445, 1979 – reference: 5) FU, K. P. & H. C. Nitu: The comparative β-lactamase resistance and inhibitory activity of 1-oxa cephalosporin, cefoxitin and cefotaxime. J. Antibiot. 32: 909-914, 1979 – reference: 3) NEU, H. C.; N. ASWAPOKRE, K. P. Fu & P. ASWAPOKEB: Antibacterial activity of a now 1 oxa cephalosporin compared with that of other β-lactam compounds. Antimicr. Agents & Chemoth. 16: 141-149, 1979 |
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| Title | FUNDAMENTAL AND CLINICAL STUDIES OF 6059-S IN SURGICAL FIELD |
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