長期少量ジスチグミン臭化物内服中にコリン作動性クリーゼにより高度徐脈に陥った一症例
Distigmine bromide, a cholinesterase inhibitor widely used for the treatment of underactive neurogenic bladder, can occasionally precipitate cholinergic crisis. We report a 67-year-old woman with neurogenic bladder who had been taking 5mg distigmine bromide orally daily for two years, but developed...
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| Published in | CIRCULATION CONTROL Vol. 34; no. 1-3; pp. 78 - 81 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本循環制御医学会
2014
Japan Society of Circulation Control in Medicine |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0389-1844 |
| DOI | 10.11312/ccm.34.78 |
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| Abstract | Distigmine bromide, a cholinesterase inhibitor widely used for the treatment of underactive neurogenic bladder, can occasionally precipitate cholinergic crisis. We report a 67-year-old woman with neurogenic bladder who had been taking 5mg distigmine bromide orally daily for two years, but developed severe bradycardia when she became dehydrated as a result of diarrhea. She was admitted to the emergency department of our hospital with severe diarrhoea and respiratory failure, and subsequently suffered severe bradycardia. She was soon resuscitated with intravenous injections of atropine and adrenalin, accompanied by insertion of a temporary pacemaker. She was diagnosed with cholinergic crisis induced by distigmine bromide, with myosis and excess salivation. This case suggests that even a small dose of distigmine bromide can induce cholinergic crisis during dehydration caused by severe diarrhoea. |
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| AbstractList | Distigmine bromide, a cholinesterase inhibitor widely used for the treatment of underactive neurogenic bladder, can occasionally precipitate cholinergic crisis. We report a 67-year-old woman with neurogenic bladder who had been taking 5mg distigmine bromide orally daily for two years, but developed severe bradycardia when she became dehydrated as a result of diarrhea. She was admitted to the emergency department of our hospital with severe diarrhoea and respiratory failure, and subsequently suffered severe bradycardia. She was soon resuscitated with intravenous injections of atropine and adrenalin, accompanied by insertion of a temporary pacemaker. She was diagnosed with cholinergic crisis induced by distigmine bromide, with myosis and excess salivation. This case suggests that even a small dose of distigmine bromide can induce cholinergic crisis during dehydration caused by severe diarrhoea. |
| Author | 高倉, 康 松木, 悠佳 村上, 剛 松木, 泰成 安田, 善一 重見, 研司 |
| Author_FL | Shigemi Kenji Murakami Tsuyoshi Matsuki Yuka Yasuda Yoshikazu Matsuki Yasunari Takakura Ko |
| Author_FL_xml | – sequence: 1 fullname: Matsuki Yuka – sequence: 2 fullname: Matsuki Yasunari – sequence: 3 fullname: Yasuda Yoshikazu – sequence: 4 fullname: Murakami Tsuyoshi – sequence: 5 fullname: Takakura Ko – sequence: 6 fullname: Shigemi Kenji |
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| References | 早川峰司, 丸藤 哲, 森本裕二ら: 常用量のジスチグミンによるコリン作動性クリーゼ. 日救急医会誌 2001; 12: 256-60. 長谷川真基, 高木維治, 平井長年ら: 臭化ジスチグミンの長期投与中にコリン作動性クリーゼを発症した慢性期脳梗塞の一例. J Clin Rehabil 2009; 18: 283-6. Vree TB, Waitzinger J, Hammermaier A, et al: Absolute bioavailability, pharmacckinetics, renal and biliary clearance of distigmine after a single oral dose in comparison to i.v. administration of 14C-distigmin-bromide in healthy volunteers. Int J Clin Pharmacol Ther 1999; 37: 393-403. 方山真朱, 熊澤淳史, 大江恭司ら: ジスチグミン臭化物の慢性中毒に伴うコリン作動性クリーゼの一症例. 日集中医誌 2011; 18: 227-31. 岩壁秀樹, 河本英作, 高橋裕ら: 排尿障害に使用したコリンエステラーゼ阻害薬Distigmine bromide(Ubretid®)による急性中毒の1例. 内科 1992; 70; 765-7. 山中滋木, 藤田一郎, 室田卓之ら: 臭化ジスチグミンによるコリン作動性クリーゼを呈した1例. 泌尿紀要 2002; 48: 21-3. 松尾康滋, 井上雅晴, 高橋修ら: 透析患者に生じたジスチグミン投与による急性中毒症状の1例. 日透析医学会誌 1999; 32: 700. 鳥居薬品株式会社社内資料. ウブレチド錠® 5mg総合製品情報概要. 2012. 植木正明, 白川洋一, 相引眞幸ら: 臭化ジスチグミン中毒の1症例. 中毒研究 1991; 4: 383-5. Hamed A, Charles TJ: Cholinergic crisis following treatment of postoperative urinary retention with distigmine bromide. Br J Clin Pract 1994; 48: 103-4. |
| References_xml | – reference: 岩壁秀樹, 河本英作, 高橋裕ら: 排尿障害に使用したコリンエステラーゼ阻害薬Distigmine bromide(Ubretid®)による急性中毒の1例. 内科 1992; 70; 765-7. – reference: 長谷川真基, 高木維治, 平井長年ら: 臭化ジスチグミンの長期投与中にコリン作動性クリーゼを発症した慢性期脳梗塞の一例. J Clin Rehabil 2009; 18: 283-6. – reference: 植木正明, 白川洋一, 相引眞幸ら: 臭化ジスチグミン中毒の1症例. 中毒研究 1991; 4: 383-5. – reference: Vree TB, Waitzinger J, Hammermaier A, et al: Absolute bioavailability, pharmacckinetics, renal and biliary clearance of distigmine after a single oral dose in comparison to i.v. administration of 14C-distigmin-bromide in healthy volunteers. Int J Clin Pharmacol Ther 1999; 37: 393-403. – reference: 山中滋木, 藤田一郎, 室田卓之ら: 臭化ジスチグミンによるコリン作動性クリーゼを呈した1例. 泌尿紀要 2002; 48: 21-3. – reference: 方山真朱, 熊澤淳史, 大江恭司ら: ジスチグミン臭化物の慢性中毒に伴うコリン作動性クリーゼの一症例. 日集中医誌 2011; 18: 227-31. – reference: Hamed A, Charles TJ: Cholinergic crisis following treatment of postoperative urinary retention with distigmine bromide. Br J Clin Pract 1994; 48: 103-4. – reference: 松尾康滋, 井上雅晴, 高橋修ら: 透析患者に生じたジスチグミン投与による急性中毒症状の1例. 日透析医学会誌 1999; 32: 700. – reference: 早川峰司, 丸藤 哲, 森本裕二ら: 常用量のジスチグミンによるコリン作動性クリーゼ. 日救急医会誌 2001; 12: 256-60. – reference: 鳥居薬品株式会社社内資料. ウブレチド錠® 5mg総合製品情報概要. 2012. |
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| SubjectTerms | cardiopulmonary arrest cholinergic crisis dehydration diarrhea distigmine bromide |
| Title | 長期少量ジスチグミン臭化物内服中にコリン作動性クリーゼにより高度徐脈に陥った一症例 |
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