顎下腺唾石症として経過観察されていた石灰化と骨形成を伴う顎下腺悪性腫瘍の1例

Salivary gland adenocarcinoma, not otherwise specified (NOS), is an epithelial carcinoma forming ductal or glandular structures that lack sufficient histologic features of the currently recognized categories of salivary gland carcinoma. We report an extremely rare case of adenocarcinoma, NOS, with c...

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Published in日本口腔外科学会雑誌 Vol. 65; no. 7; pp. 461 - 466
Main Authors 大前, 政利, 藤田, 祐生, 若林, 健, 奥長, 秀介, 墨, 哲郎, 太田, 嘉幸
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.07.2019
Subjects
唾石症
石灰化
腺癌 NOS
顎下腺悪性腫瘍
骨形成
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.65.461

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Abstract Salivary gland adenocarcinoma, not otherwise specified (NOS), is an epithelial carcinoma forming ductal or glandular structures that lack sufficient histologic features of the currently recognized categories of salivary gland carcinoma. We report an extremely rare case of adenocarcinoma, NOS, with calcification and bone formation in the submandibular gland.　A 44-year-old man who was referred to our department had been given a diagnosis of sialolithiasis of the right submandibular gland at a referral hospital a few years ago. CT and MR images revealed a 15-mm calcified substance in the right submandibular gland, and FDG-PET images revealed multiple abnormal uptakes in the cervical lymph nodes. We diagnosed a malignant submandibular gland tumor with multiple lymph node metastases of the neck and performed radical surgery with the patient under general anesthesia. Histological analysis of the surgical specimen revealed that the tumor was a high-grade adenocarcinoma, NOS, with dystrophic calcification and bone formation; moreover, multiple cervical metastatic nodes were detected with extracapsular invasion. Therefore, he underwent cetuximab-based bioradiotherapy as an adjuvant therapy. He has been followed up closely, and no recurrence has been noted.
AbstractList Salivary gland adenocarcinoma, not otherwise specified (NOS), is an epithelial carcinoma forming ductal or glandular structures that lack sufficient histologic features of the currently recognized categories of salivary gland carcinoma. We report an extremely rare case of adenocarcinoma, NOS, with calcification and bone formation in the submandibular gland.　A 44-year-old man who was referred to our department had been given a diagnosis of sialolithiasis of the right submandibular gland at a referral hospital a few years ago. CT and MR images revealed a 15-mm calcified substance in the right submandibular gland, and FDG-PET images revealed multiple abnormal uptakes in the cervical lymph nodes. We diagnosed a malignant submandibular gland tumor with multiple lymph node metastases of the neck and performed radical surgery with the patient under general anesthesia. Histological analysis of the surgical specimen revealed that the tumor was a high-grade adenocarcinoma, NOS, with dystrophic calcification and bone formation; moreover, multiple cervical metastatic nodes were detected with extracapsular invasion. Therefore, he underwent cetuximab-based bioradiotherapy as an adjuvant therapy. He has been followed up closely, and no recurrence has been noted.
Author 墨, 哲郎
太田, 嘉幸
大前, 政利
若林, 健
奥長, 秀介
藤田, 祐生
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References 13) 村上秀明：総説 唾液腺悪性腫瘍の放射線治療．日口外誌 57: 6-9, 2011.
6) Chen Y, Lin L, et al : Palatal pleomorphic adenoma in a child with osteoid formation: report of case. ASDC J Dent Child 65: 209-211, 1998.
7) 森永正二郎：唾液腺の解剖と腫瘍の組織発生．病理と臨床 7: 545-559, 1989.
2) 新井俊弘， 太田嘉英， 他：石灰化を認めた顎下腺腺房細胞癌の1例．口腔腫瘍 25: 7-11, 2013.
14) Amini A, Waxweiler TV, et al : Association of Adjuvant Chemoradiotherapy vs Radiotherapy Alone With Survival in Patients With Resected Major Salivary Gland Carcinoma : Data From the National Cancer Data Base. JAMA Otolaryngol Head Neck Surg 142: 1100-1110, 2016.
3) 福田康夫， 岸野万伸， 他：石灰化を伴う唾液腺腫瘍．日病理誌 79: 287-290, 1990.
5) Yates PO and Paget GE : A mixed tumour of salivary gland showing bone formation with a histochemical study of the tumour mucoids. J Pathol Bacteriol 64: 881-888, 1952.
12) 久保田彰：唾液腺癌に対する化学療法の意義と実際．頭頸部癌 33: 254-259, 2007.
15) Locati LD, Bossi P, et al : Cetuximab in recurrent and/or metastatic salivary gland carcinomas : A phase II study. Oral Oncol 45: 574-578, 2009.
1) 小村 健：唾液腺腫瘍の外科療法．口腔腫瘍 23: 73-81, 2011.
11) 佐々木徹， 川端一嘉， 他：顎下腺癌の治療．頭頸部癌 39: 281-286, 2013.
8) 米川敦子， 岩井聡一， 他：被膜に著明な石灰化と骨形成を認めた顎下腺多形腺腫の1例．日口外誌 58: 217-221, 2012.
4) Yoon JH, Ahn SG, et al : Calcifications in a clear cell mucoepidermoid carcinoma of the hard palate. Int J Oral Maxillofac Surg 34: 927-929, 2005.
16) Locati LD, Perrone F, et al : Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). Oral Oncol 45: 986-990, 2009.
9) Licitra L, Cavina R, et al : Cisplatin, doxorubicin and cyclophosphamide in advanced salivary gland carcinoma. Ann Oncol 7: 640-642, 1996.
10) Lagha A, Chraiet N, et al : Systemic therapy in the management of metastatic or advanced salivary gland cancers. Oral Oncol 48: 948-957, 2012.
References_xml – reference: 2) 新井俊弘， 太田嘉英， 他：石灰化を認めた顎下腺腺房細胞癌の1例．口腔腫瘍 25: 7-11, 2013.
– reference: 4) Yoon JH, Ahn SG, et al : Calcifications in a clear cell mucoepidermoid carcinoma of the hard palate. Int J Oral Maxillofac Surg 34: 927-929, 2005.
– reference: 3) 福田康夫， 岸野万伸， 他：石灰化を伴う唾液腺腫瘍．日病理誌 79: 287-290, 1990.
– reference: 6) Chen Y, Lin L, et al : Palatal pleomorphic adenoma in a child with osteoid formation: report of case. ASDC J Dent Child 65: 209-211, 1998.
– reference: 14) Amini A, Waxweiler TV, et al : Association of Adjuvant Chemoradiotherapy vs Radiotherapy Alone With Survival in Patients With Resected Major Salivary Gland Carcinoma : Data From the National Cancer Data Base. JAMA Otolaryngol Head Neck Surg 142: 1100-1110, 2016.
– reference: 11) 佐々木徹， 川端一嘉， 他：顎下腺癌の治療．頭頸部癌 39: 281-286, 2013.
– reference: 9) Licitra L, Cavina R, et al : Cisplatin, doxorubicin and cyclophosphamide in advanced salivary gland carcinoma. Ann Oncol 7: 640-642, 1996.
– reference: 10) Lagha A, Chraiet N, et al : Systemic therapy in the management of metastatic or advanced salivary gland cancers. Oral Oncol 48: 948-957, 2012.
– reference: 15) Locati LD, Bossi P, et al : Cetuximab in recurrent and/or metastatic salivary gland carcinomas : A phase II study. Oral Oncol 45: 574-578, 2009.
– reference: 12) 久保田彰：唾液腺癌に対する化学療法の意義と実際．頭頸部癌 33: 254-259, 2007.
– reference: 16) Locati LD, Perrone F, et al : Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). Oral Oncol 45: 986-990, 2009.
– reference: 13) 村上秀明：総説 唾液腺悪性腫瘍の放射線治療．日口外誌 57: 6-9, 2011.
– reference: 7) 森永正二郎：唾液腺の解剖と腫瘍の組織発生．病理と臨床 7: 545-559, 1989.
– reference: 8) 米川敦子， 岩井聡一， 他：被膜に著明な石灰化と骨形成を認めた顎下腺多形腺腫の1例．日口外誌 58: 217-221, 2012.
– reference: 5) Yates PO and Paget GE : A mixed tumour of salivary gland showing bone formation with a histochemical study of the tumour mucoids. J Pathol Bacteriol 64: 881-888, 1952.
– reference: 1) 小村 健：唾液腺腫瘍の外科療法．口腔腫瘍 23: 73-81, 2011.
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Snippet Salivary gland adenocarcinoma, not otherwise specified (NOS), is an epithelial carcinoma forming ductal or glandular structures that lack sufficient histologic...
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StartPage 461
SubjectTerms 唾石症
石灰化
腺癌 NOS
顎下腺悪性腫瘍
骨形成
Title 顎下腺唾石症として経過観察されていた石灰化と骨形成を伴う顎下腺悪性腫瘍の1例
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