口蓋に発生した多形腺腫由来筋上皮癌の1例

Carcinoma ex pleomorphic adenoma mainly occurs in the major salivary gland, and a tissue type of myoepithelial carcinoma is extremely rare in the minor salivary gland. We report a case of myoepithelial carcinoma ex pleomorphic adenoma of the hard palate in a 65-year-old man. At presentation, a tumor...

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Published in日本口腔外科学会雑誌 Vol. 61; no. 3; pp. 173 - 176
Main Authors 荻, 和弘, 宮崎, 晃亘, 井手, 隆, 竹田, 康佑, 平塚, 博義, 小林, 淳一
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.03.2015
Subjects
多形腺腫由来筋上皮癌
小唾液腺
硬口蓋
Online AccessGet full text
ISSN0021-5163
2186-1579
DOI10.5794/jjoms.61.173

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Abstract Carcinoma ex pleomorphic adenoma mainly occurs in the major salivary gland, and a tissue type of myoepithelial carcinoma is extremely rare in the minor salivary gland. We report a case of myoepithelial carcinoma ex pleomorphic adenoma of the hard palate in a 65-year-old man. At presentation, a tumor measuring 23 × 16 mm, which had a painless elastic hard, smooth surface and clear border, was found in the right side of the hard palate. Computed tomographic scanning and magnetic resonance imaging indicated the suspicion of malignancy. Histological examination suggested a myoepithelial carcinoma. A partial maxillectomy combined with a supraomohyoid neck dissection was performed. The histological diagnosis of the resected specimen was a myoepithelial carcinoma ex pleomorphic adenoma. There has been no sign of recurrence as of 2 years postoperatively.
AbstractList Carcinoma ex pleomorphic adenoma mainly occurs in the major salivary gland, and a tissue type of myoepithelial carcinoma is extremely rare in the minor salivary gland. We report a case of myoepithelial carcinoma ex pleomorphic adenoma of the hard palate in a 65-year-old man. At presentation, a tumor measuring 23 × 16 mm, which had a painless elastic hard, smooth surface and clear border, was found in the right side of the hard palate. Computed tomographic scanning and magnetic resonance imaging indicated the suspicion of malignancy. Histological examination suggested a myoepithelial carcinoma. A partial maxillectomy combined with a supraomohyoid neck dissection was performed. The histological diagnosis of the resected specimen was a myoepithelial carcinoma ex pleomorphic adenoma. There has been no sign of recurrence as of 2 years postoperatively.
Author 荻, 和弘
竹田, 康佑
井手, 隆
小林, 淳一
宮崎, 晃亘
平塚, 博義
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References 4) Otoh EC, Johnson NW, et al : Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis 11: 386-391, 2005.
26) Lewis JE, Olsen KD, et al : Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 32: 596-604, 2001.
28) Mariano FV, Noronha AL, et al : Carcinoma ex pleomorphic adenoma in a Brazilian population: clinicopathological analysis of 38 cases. Int J Oral Maxillofac Surg 42: 685-692, 2013.
14) Toida M, Shimokawa K, et al : Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34: 528-532, 2005.
5) Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg 65: 2187-2194, 2007.
19) Dhanuthai K, Boonadulyarat M, et al : A clinicopathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med 38: 495-500, 2009.
6) Subhashraj K: Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg 46: 635-638, 2008.
18) Wang D, Li Y, et al : Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104: 94-100, 2007.
17) Pires FR, Pringle GA, et al : Intra-oral minor salivary glands tumors: a clinicopathological study of 546 cases. Oral Oncol 43: 463-470, 2007.
12) Lukšić I, Virag M, et al : Salivary gland tumours: 25 years of experience from a single institution in Croatia. J Cranio-Maxillofac Surg 40: e75-e81, 2012.
27) Lim CM, Hobson C, et al : Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center. Head Neck 2014. doi: 10.1002/ hed. 23638. Accepted February 17, 2014.
25) 渡邉裕之, 河原　康, 他：当科における口腔内小唾液腺癌の臨床的検討. 愛院大歯誌 51: 471-474, 2013.
3) Zbären P, Zbären S, et al : Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg 138: 601-605, 2008.
7) Long-Jiang L, Yi L, et al : Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol 44: 187-192, 2008.
9) Kara MI, Göze F, et al : Neoplasms of the salivary glands in a Turkish adult population. Med Oral Pathol Oral Cir Buccal 15: e880-885, 2010.
16) Buchner A, Merrell PW, et al : Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med 36: 207-214, 2007.
24) 田中香衣, 小村　健, 他：口腔内小唾液腺癌45例の臨床的検討. 口腔腫瘍 24: 21-27, 2012.
15) Jaber MA: Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population. Int J Oral Maxillofac Surg 35: 150-154, 2006.
21) Stric MJ, Kelly C, et al : Malignant tumours of the minor salivary glands-a 20 year review. Br J Oral Maxillofac Surg 57: 624-631, 2004.
13) Yih W-Y, Kratochvil FJ, et al : Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg 63: 805-810, 2005.
22) Copelli C, Bianchi S, et al : Malignant tumors of intraoral minor salivary glands. Oral Oncol 44: 658-663, 2008.
10) Tian Z, Li L, et al : Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Cinese population. Int J Oral Maxillifac Surg 39: 235-242, 2010.
8) Jones AV, Craig GT, et al : The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol 44: 407-417, 2008.
2) Przewozny T and Stankiewicz C: Neoplasms of the parotid gland in northern Poland, 1991-2000: an epidemiologic study. Eur Arch Otorhinolaryngol 261: 369-375, 2004.
1) Gnepp DR, Brandwein-Gensler MS, et al : Carcinoma ex pleomorphic adenoma. In Barnes L, Eveson JW, eds; WHO classification of Pathology and Genetics of Head and Neck Tumors. IARC Press, Lyon, 2005, p242-243.
20) Vani NV and Ponniah I: The frequency and distribution pattern of minor salivary gland tumors in a government dental teaching hospital, Chennai, India. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111: e32-e39, 2011.
29) 矢田直美, 駄阿　勉, 他：唾液腺腫瘍の診断に有用な免疫組織化学―筋上皮細胞マーカーを中心に―. 病理と臨床 29: 591-595, 2011.
23) Mücke T, Robitzky LK, et al : Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108: 81-89, 2009.
11) Shishegar M, Ashraf MJ, et al : Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Pathol Res Int 2011. Article ID 934350, 5 pages, doi: 10.4061/ 2011/ 934350. Accepted May 10, 2011.
References_xml – reference: 29) 矢田直美, 駄阿　勉, 他：唾液腺腫瘍の診断に有用な免疫組織化学―筋上皮細胞マーカーを中心に―. 病理と臨床 29: 591-595, 2011.
– reference: 22) Copelli C, Bianchi S, et al : Malignant tumors of intraoral minor salivary glands. Oral Oncol 44: 658-663, 2008.
– reference: 15) Jaber MA: Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population. Int J Oral Maxillofac Surg 35: 150-154, 2006.
– reference: 19) Dhanuthai K, Boonadulyarat M, et al : A clinicopathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med 38: 495-500, 2009.
– reference: 26) Lewis JE, Olsen KD, et al : Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 32: 596-604, 2001.
– reference: 1) Gnepp DR, Brandwein-Gensler MS, et al : Carcinoma ex pleomorphic adenoma. In Barnes L, Eveson JW, eds; WHO classification of Pathology and Genetics of Head and Neck Tumors. IARC Press, Lyon, 2005, p242-243.
– reference: 5) Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg 65: 2187-2194, 2007.
– reference: 17) Pires FR, Pringle GA, et al : Intra-oral minor salivary glands tumors: a clinicopathological study of 546 cases. Oral Oncol 43: 463-470, 2007.
– reference: 20) Vani NV and Ponniah I: The frequency and distribution pattern of minor salivary gland tumors in a government dental teaching hospital, Chennai, India. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111: e32-e39, 2011.
– reference: 24) 田中香衣, 小村　健, 他：口腔内小唾液腺癌45例の臨床的検討. 口腔腫瘍 24: 21-27, 2012.
– reference: 11) Shishegar M, Ashraf MJ, et al : Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Pathol Res Int 2011. Article ID 934350, 5 pages, doi: 10.4061/ 2011/ 934350. Accepted May 10, 2011.
– reference: 8) Jones AV, Craig GT, et al : The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol 44: 407-417, 2008.
– reference: 27) Lim CM, Hobson C, et al : Clinical outcome of patients with carcinoma ex pleomorphic adenoma of the parotid gland: a comparative study from a single tertiary center. Head Neck 2014. doi: 10.1002/ hed. 23638. Accepted February 17, 2014.
– reference: 23) Mücke T, Robitzky LK, et al : Advanced malignant minor salivary glands tumors of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108: 81-89, 2009.
– reference: 14) Toida M, Shimokawa K, et al : Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34: 528-532, 2005.
– reference: 3) Zbären P, Zbären S, et al : Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg 138: 601-605, 2008.
– reference: 2) Przewozny T and Stankiewicz C: Neoplasms of the parotid gland in northern Poland, 1991-2000: an epidemiologic study. Eur Arch Otorhinolaryngol 261: 369-375, 2004.
– reference: 10) Tian Z, Li L, et al : Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Cinese population. Int J Oral Maxillifac Surg 39: 235-242, 2010.
– reference: 21) Stric MJ, Kelly C, et al : Malignant tumours of the minor salivary glands-a 20 year review. Br J Oral Maxillofac Surg 57: 624-631, 2004.
– reference: 25) 渡邉裕之, 河原　康, 他：当科における口腔内小唾液腺癌の臨床的検討. 愛院大歯誌 51: 471-474, 2013.
– reference: 6) Subhashraj K: Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg 46: 635-638, 2008.
– reference: 18) Wang D, Li Y, et al : Intraoral minor salivary gland tumors in a Chinese population: a retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104: 94-100, 2007.
– reference: 12) Lukšić I, Virag M, et al : Salivary gland tumours: 25 years of experience from a single institution in Croatia. J Cranio-Maxillofac Surg 40: e75-e81, 2012.
– reference: 16) Buchner A, Merrell PW, et al : Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med 36: 207-214, 2007.
– reference: 13) Yih W-Y, Kratochvil FJ, et al : Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg 63: 805-810, 2005.
– reference: 28) Mariano FV, Noronha AL, et al : Carcinoma ex pleomorphic adenoma in a Brazilian population: clinicopathological analysis of 38 cases. Int J Oral Maxillofac Surg 42: 685-692, 2013.
– reference: 4) Otoh EC, Johnson NW, et al : Salivary gland neoplasms in Maiduguri, north-eastern Nigeria. Oral Dis 11: 386-391, 2005.
– reference: 9) Kara MI, Göze F, et al : Neoplasms of the salivary glands in a Turkish adult population. Med Oral Pathol Oral Cir Buccal 15: e880-885, 2010.
– reference: 7) Long-Jiang L, Yi L, et al : Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol 44: 187-192, 2008.
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SubjectTerms 多形腺腫由来筋上皮癌
小唾液腺
硬口蓋
Title 口蓋に発生した多形腺腫由来筋上皮癌の1例
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