切除後に再発を認めた舌のhobnail hemangiomaの1例

Hobnail hemangiomas are benign vascular lesions, and their occurrence in the oral cavity is relatively rare. Here, we report a case of hobnail hemangioma that occurred on the tongue. The patient, an 84-year-old woman, was referred to our oral and maxillofacial surgery by the internal medicine depart...

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Published in日本口腔外科学会雑誌 Vol. 67; no. 4; pp. 239 - 242
Main Authors 槇野, 隆秀, 國定, 勇希, 佐々木, 朗, 伊原木, 聰一郎, 小野, 喜章, 熊谷, 智代
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.04.2021
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.67.239

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Abstract Hobnail hemangiomas are benign vascular lesions, and their occurrence in the oral cavity is relatively rare. Here, we report a case of hobnail hemangioma that occurred on the tongue. The patient, an 84-year-old woman, was referred to our oral and maxillofacial surgery by the internal medicine department in June 2018. The mass on the lower surface of the right side of her tongue was a 6 × 6-mm-sized dark-brown, elastic, relatively hard, and elevated lesion that did not fade when pressure was applied. Total resection was performed under local anesthesia. Histopathological examination revealed a biphasic growth pattern with irregular, dilated, thin-walled vessels in the superficial parts of the lesion and slit-like vessels in the deeper portion. The plump endothelial cells in the superficial vessels showed the characteristic“ hobnail” appearance. Immunohistochemically, the endothelial cells were positive for endothelial markers and/or lymphatic endothelial markers to varying degrees. Based on the clinical and histopathological findings, the lesion was diagnosed as hobnail hemangioma. However, recurrence occurred 6 months after resection, so the mass and surrounding tissue were totally resected. The patient’s prognosis is currently favorable, with no signs of recurrence two years after the second resection.
AbstractList Hobnail hemangiomas are benign vascular lesions, and their occurrence in the oral cavity is relatively rare. Here, we report a case of hobnail hemangioma that occurred on the tongue. The patient, an 84-year-old woman, was referred to our oral and maxillofacial surgery by the internal medicine department in June 2018. The mass on the lower surface of the right side of her tongue was a 6 × 6-mm-sized dark-brown, elastic, relatively hard, and elevated lesion that did not fade when pressure was applied. Total resection was performed under local anesthesia. Histopathological examination revealed a biphasic growth pattern with irregular, dilated, thin-walled vessels in the superficial parts of the lesion and slit-like vessels in the deeper portion. The plump endothelial cells in the superficial vessels showed the characteristic“ hobnail” appearance. Immunohistochemically, the endothelial cells were positive for endothelial markers and/or lymphatic endothelial markers to varying degrees. Based on the clinical and histopathological findings, the lesion was diagnosed as hobnail hemangioma. However, recurrence occurred 6 months after resection, so the mass and surrounding tissue were totally resected. The patient’s prognosis is currently favorable, with no signs of recurrence two years after the second resection.
Author 佐々木, 朗
伊原木, 聰一郎
槇野, 隆秀
熊谷, 智代
國定, 勇希
小野, 喜章
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References 14) Hiremath SKS, Charantimath S, et al : Oral hobnail hemangioma: a case report. Arch Iran Med 16: 428-430, 2013.
17) Franke FE, Steger K, et al : Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31: 362-367, 2004.
7) 中野英司, 藤原 進, 他:生検後に消退傾向を示したhobnail hemangiomaの1例.皮の科 8: 416-421, 2009.
4) Christenson LJ and Stone MS : Trauma-induced simulator of targetoid hemosiderotic hemangioma. Am J Dermatopathol 23: 221-223, 2001.
15) Alhassani M, Santhanam V, et al : Oral superficial haemosiderotic lymphovascular malformation: a rare presentation. BMJ Case Rep 2018: bcr-2017-223043, 2018.
9) 永廣利恵, 青井 淳, 他:Hobnail hemangiomaの1例.皮膚臨床 52: 1909-1911, 2010.
2) 幸田 太, 古江増隆, 他: Targetoid hemosiderotic hemangioma. 日皮会誌 109: 893-897, 1999.
8) 竹田恵子, 飯沼 晋, 他: Targetoid hemosiderotic hemangiomaの1例.皮膚臨床 51: 1044-1045, 1961-1962, 2009.
12) Rashmi MS, Alka KD, et al : Oral hobnail hemangioma: a case report. Quintessence Int 39: 507-510, 2008.
5) Morganroth GS, Tigelaar RE, et al : Targetoid hemangioma associated with pregnancy and the menstrual cycle. J Am Acad Dermatol 32: 282-284, 1995.
10) 奥野愛香, 服部ゆかり, 他:鋲釘血管腫の1例.臨皮 68: 705-710, 2014.
11) Takayama R, Ueno T, et al : Hobnail hemangioma: a case report. J Nippon Med Sch 82: 151-155, 2015.
1) Santa Cruz DJ and Aronberg J : Targetoid hemosiderotic hemangioma. J Am Acad Dermatol 19: 550-558, 1988.
6) ISSVA classification of vascular tumors 1b. ISSVA classification for vascular anomalies© : 3, 2018. Available at: https://www.issva.org/UserFiles/file/ISSVA-Classification-2018.pdf. Accessed December 1, 2020.
18) Hejnold M, Dyduch G, et al : Hobnail hemangioma: a immunohistochemical study and literature review. Pol J Pathol 3: 189-192, 2012.
13) Vieira CSE, Chain HHR, et al : Oral hobnail hemangioma: case report. Minerva Stomatol 58: 613-616, 2009.
3) Carlson JA, Daulat S, et al : Targetoid hemosiderotic hemangioma- a dynamic vascular tumor: report of 3 cases with episodic and cyclic changes and comparison with solitary angiokeratomas. J Am Acad Dermatol 41: 215-224, 1999.
16) Mentzel T, Partanen TA, et al : Hobnail hemangioma (“targetoid hemosiderotic hemangioma”): clinicopathologic and immunohistochemical analysis of 62cases. J Cutan Pathol 26: 279-286, 1999.
References_xml – reference: 12) Rashmi MS, Alka KD, et al : Oral hobnail hemangioma: a case report. Quintessence Int 39: 507-510, 2008.
– reference: 13) Vieira CSE, Chain HHR, et al : Oral hobnail hemangioma: case report. Minerva Stomatol 58: 613-616, 2009.
– reference: 10) 奥野愛香, 服部ゆかり, 他:鋲釘血管腫の1例.臨皮 68: 705-710, 2014.
– reference: 18) Hejnold M, Dyduch G, et al : Hobnail hemangioma: a immunohistochemical study and literature review. Pol J Pathol 3: 189-192, 2012.
– reference: 14) Hiremath SKS, Charantimath S, et al : Oral hobnail hemangioma: a case report. Arch Iran Med 16: 428-430, 2013.
– reference: 3) Carlson JA, Daulat S, et al : Targetoid hemosiderotic hemangioma- a dynamic vascular tumor: report of 3 cases with episodic and cyclic changes and comparison with solitary angiokeratomas. J Am Acad Dermatol 41: 215-224, 1999.
– reference: 5) Morganroth GS, Tigelaar RE, et al : Targetoid hemangioma associated with pregnancy and the menstrual cycle. J Am Acad Dermatol 32: 282-284, 1995.
– reference: 8) 竹田恵子, 飯沼 晋, 他: Targetoid hemosiderotic hemangiomaの1例.皮膚臨床 51: 1044-1045, 1961-1962, 2009.
– reference: 9) 永廣利恵, 青井 淳, 他:Hobnail hemangiomaの1例.皮膚臨床 52: 1909-1911, 2010.
– reference: 17) Franke FE, Steger K, et al : Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 31: 362-367, 2004.
– reference: 16) Mentzel T, Partanen TA, et al : Hobnail hemangioma (“targetoid hemosiderotic hemangioma”): clinicopathologic and immunohistochemical analysis of 62cases. J Cutan Pathol 26: 279-286, 1999.
– reference: 6) ISSVA classification of vascular tumors 1b. ISSVA classification for vascular anomalies© : 3, 2018. Available at: https://www.issva.org/UserFiles/file/ISSVA-Classification-2018.pdf. Accessed December 1, 2020.
– reference: 7) 中野英司, 藤原 進, 他:生検後に消退傾向を示したhobnail hemangiomaの1例.皮の科 8: 416-421, 2009.
– reference: 11) Takayama R, Ueno T, et al : Hobnail hemangioma: a case report. J Nippon Med Sch 82: 151-155, 2015.
– reference: 1) Santa Cruz DJ and Aronberg J : Targetoid hemosiderotic hemangioma. J Am Acad Dermatol 19: 550-558, 1988.
– reference: 15) Alhassani M, Santhanam V, et al : Oral superficial haemosiderotic lymphovascular malformation: a rare presentation. BMJ Case Rep 2018: bcr-2017-223043, 2018.
– reference: 4) Christenson LJ and Stone MS : Trauma-induced simulator of targetoid hemosiderotic hemangioma. Am J Dermatopathol 23: 221-223, 2001.
– reference: 2) 幸田 太, 古江増隆, 他: Targetoid hemosiderotic hemangioma. 日皮会誌 109: 893-897, 1999.
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鋲釘血管腫
Title 切除後に再発を認めた舌のhobnail hemangiomaの1例
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