甲状腺転移をきたした下顎歯肉紡錘細胞癌の1例

Spindle cell carcinoma is a tumor histologically characterized by polymorphic cells comprising mainly spindle-shaped cells that proliferate and present with an image reminiscent of sarcoma. Reports of this carcinoma in the oral cavity region are rare, and there have been no reports, either in Japan...

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Published in日本口腔外科学会雑誌 Vol. 64; no. 3; pp. 170 - 174
Main Authors 伏見, 千宙, 黒坂, 正生, 菅野, 千敬, 荘司, 洋文, 猪俣, 徹, 吉田, 和正
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.03.2018
Subjects
下顎歯肉
甲状腺
紡錘細胞癌
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.64.170

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Abstract Spindle cell carcinoma is a tumor histologically characterized by polymorphic cells comprising mainly spindle-shaped cells that proliferate and present with an image reminiscent of sarcoma. Reports of this carcinoma in the oral cavity region are rare, and there have been no reports, either in Japan or in other countries, of metastasis to the thyroid gland. The authors encountered a case in which spindle cell carcinoma recurred after resection and metastasized to the thyroid gland and describe the outcome. The patient was a 76-year-old man with spindle cell carcinoma of the mandibular gingiva who underwent resection of the borders of the mandible, supraomohyoid neck dissection and reconstruction using a free forearm flap. Eleven months later, however, localized recurrence of the carcinoma was seen in the medial pterygoid muscle. The patient underwent surgery again, followed by postoperative radiotherapy alone. Because metastasis to the right lobe of the thyroid gland was observed, however, the patient underwent total thyroidectomy. One year 5 months after surgery, the patient is doing well, with no further recurrence or metastasis.
AbstractList Spindle cell carcinoma is a tumor histologically characterized by polymorphic cells comprising mainly spindle-shaped cells that proliferate and present with an image reminiscent of sarcoma. Reports of this carcinoma in the oral cavity region are rare, and there have been no reports, either in Japan or in other countries, of metastasis to the thyroid gland. The authors encountered a case in which spindle cell carcinoma recurred after resection and metastasized to the thyroid gland and describe the outcome. The patient was a 76-year-old man with spindle cell carcinoma of the mandibular gingiva who underwent resection of the borders of the mandible, supraomohyoid neck dissection and reconstruction using a free forearm flap. Eleven months later, however, localized recurrence of the carcinoma was seen in the medial pterygoid muscle. The patient underwent surgery again, followed by postoperative radiotherapy alone. Because metastasis to the right lobe of the thyroid gland was observed, however, the patient underwent total thyroidectomy. One year 5 months after surgery, the patient is doing well, with no further recurrence or metastasis.
Author 吉田, 和正
荘司, 洋文
猪俣, 徹
黒坂, 正生
伏見, 千宙
菅野, 千敬
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  fullname: 黒坂, 正生
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References 19) 平能康充， 渡辺　透， 他: 腎細胞癌摘除10年後に孤立性甲状腺転移を認めた1例. 日臨外医会誌 62: 38-42, 2001.
4) Zidar N, Gale N, et al : Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. Virchows Arch 453: 267-274, 2008.
9) 本田博之， 松澤壽章， 他：扁平上皮癌に連続して発生した舌紡錘細胞癌の1例．日口外誌 56: 53-57, 2010.
13) Colozza M, Grignani F, et al : Metastatic spindle cell carcinoma: a complete response induced by cisplatin and 5-fluorouracil. Anticancer Res 8: 457-458, 1988.
16) Barnes L and Gnepp DR : Spindle cell squamous carcinoma. In Barnes L, eds ; Surgical Pathology of the Head and Neck Vol.1. Dekker, New York, 1985, p177-180.
14) Onishi H, Kuriyama K, et al : T1N0 laryngeal sarcomatoid carcinoma that showed rapid systemic metastases after radical radiotherapy: a case report and review of literature. American Journal of Otolarygology 26: 400-402, 2005.
20) 宮嶋義巳， 佐藤公則， 他: 喉頭原発の転移性甲状腺癌．耳鼻臨床 86: 1165-1170, 1993.
2) Martin HE and Stewart FW : Spindle-cell epidermoid carcinoma. Am J Cancer 24: 273-298, 1935.
7) 吉野邦俊， 上村裕和：喉頭紡錘細胞癌．耳鼻臨床 88: 1120-1121, 1995.
10) 小村　健， 山下知巳， 他：舌紡錘細胞癌の臨床病理学的検討．頭頸部腫瘍 24: 50-55, 1998.
18) 清水一雄， 伊藤國彦， 他: 甲状腺転移をきたしたGrawits 腫瘍の2症例．日臨外医会誌 39: 373-377, 1978.
17) 井川加織， 鹿嶋光司， 他: 腫瘍切除後に急速に心筋を含む全身多臓器に転移した下顎歯肉紡錘細胞癌の1例．Hosp Dent 19: 189-193, 2007.
12) Benniger MS, Kraus D, et al : Head and neck spindle cell carcinoma; an evaluation of current management. Cleve Clin J Med 59: 479-482, 1992.
21) Michelow PM and Leiman G : Metastases to the thyroid gland; diagnosis by aspiration cytology. Diagn Cytopathol 13: 209-213, 1995.
5) 吉原俊雄， 島田哲男， 他：上顎洞に発生したSpindle cell carcinoma の1例．耳鼻咽喉 54: 731-734, 1982.
8) 内山公男， 鬼澤勝弘， 他：下顎に発生した紡錘細胞癌の1例．日口外誌 43: 401-403, 1997.
15) Su HH, Chu ST, et al : Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. J Chin Med Assoc 69: 478-483,2006.
1) 松尾美央子， 力丸文秀， 他： 頭頸部Spindle Cell Carcinoma の6 症例．日耳鼻 118: 123-128, 2015.
11) 成田七美， 今井裕子， 他：舌紡錘細胞癌の1例．耳喉頭頸 66: 101-105, 1994.
3) 益田宗幸， 有馬敏夫， 他：喉頭に発生したmonophasic Spindle cell carcinoma の1例．耳鼻と臨 38: 100-106, 1992.
22) Jalaludin MA, Rajadurai P, et al : Thyroid metastasis from nasopharyngeal carcinoma: a case report. J Laryngol Otol 108: 886-888, 1994.
6) 田中文顕， 鮫島靖浩， 他：下咽頭に発生した癌肉腫の2例．耳鼻と臨 39: 196-202, 1993.
23) 渡邊昭仁， 片山昭公， 他:下咽頭癌甲状腺転移例．頭頸部外 8: 147-150, 1998.
References_xml – reference: 22) Jalaludin MA, Rajadurai P, et al : Thyroid metastasis from nasopharyngeal carcinoma: a case report. J Laryngol Otol 108: 886-888, 1994.
– reference: 23) 渡邊昭仁， 片山昭公， 他:下咽頭癌甲状腺転移例．頭頸部外 8: 147-150, 1998.
– reference: 11) 成田七美， 今井裕子， 他：舌紡錘細胞癌の1例．耳喉頭頸 66: 101-105, 1994.
– reference: 14) Onishi H, Kuriyama K, et al : T1N0 laryngeal sarcomatoid carcinoma that showed rapid systemic metastases after radical radiotherapy: a case report and review of literature. American Journal of Otolarygology 26: 400-402, 2005.
– reference: 6) 田中文顕， 鮫島靖浩， 他：下咽頭に発生した癌肉腫の2例．耳鼻と臨 39: 196-202, 1993.
– reference: 9) 本田博之， 松澤壽章， 他：扁平上皮癌に連続して発生した舌紡錘細胞癌の1例．日口外誌 56: 53-57, 2010.
– reference: 21) Michelow PM and Leiman G : Metastases to the thyroid gland; diagnosis by aspiration cytology. Diagn Cytopathol 13: 209-213, 1995.
– reference: 17) 井川加織， 鹿嶋光司， 他: 腫瘍切除後に急速に心筋を含む全身多臓器に転移した下顎歯肉紡錘細胞癌の1例．Hosp Dent 19: 189-193, 2007.
– reference: 1) 松尾美央子， 力丸文秀， 他： 頭頸部Spindle Cell Carcinoma の6 症例．日耳鼻 118: 123-128, 2015.
– reference: 4) Zidar N, Gale N, et al : Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. Virchows Arch 453: 267-274, 2008.
– reference: 7) 吉野邦俊， 上村裕和：喉頭紡錘細胞癌．耳鼻臨床 88: 1120-1121, 1995.
– reference: 18) 清水一雄， 伊藤國彦， 他: 甲状腺転移をきたしたGrawits 腫瘍の2症例．日臨外医会誌 39: 373-377, 1978.
– reference: 5) 吉原俊雄， 島田哲男， 他：上顎洞に発生したSpindle cell carcinoma の1例．耳鼻咽喉 54: 731-734, 1982.
– reference: 2) Martin HE and Stewart FW : Spindle-cell epidermoid carcinoma. Am J Cancer 24: 273-298, 1935.
– reference: 8) 内山公男， 鬼澤勝弘， 他：下顎に発生した紡錘細胞癌の1例．日口外誌 43: 401-403, 1997.
– reference: 19) 平能康充， 渡辺　透， 他: 腎細胞癌摘除10年後に孤立性甲状腺転移を認めた1例. 日臨外医会誌 62: 38-42, 2001.
– reference: 13) Colozza M, Grignani F, et al : Metastatic spindle cell carcinoma: a complete response induced by cisplatin and 5-fluorouracil. Anticancer Res 8: 457-458, 1988.
– reference: 10) 小村　健， 山下知巳， 他：舌紡錘細胞癌の臨床病理学的検討．頭頸部腫瘍 24: 50-55, 1998.
– reference: 15) Su HH, Chu ST, et al : Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. J Chin Med Assoc 69: 478-483,2006.
– reference: 3) 益田宗幸， 有馬敏夫， 他：喉頭に発生したmonophasic Spindle cell carcinoma の1例．耳鼻と臨 38: 100-106, 1992.
– reference: 12) Benniger MS, Kraus D, et al : Head and neck spindle cell carcinoma; an evaluation of current management. Cleve Clin J Med 59: 479-482, 1992.
– reference: 16) Barnes L and Gnepp DR : Spindle cell squamous carcinoma. In Barnes L, eds ; Surgical Pathology of the Head and Neck Vol.1. Dekker, New York, 1985, p177-180.
– reference: 20) 宮嶋義巳， 佐藤公則， 他: 喉頭原発の転移性甲状腺癌．耳鼻臨床 86: 1165-1170, 1993.
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Snippet Spindle cell carcinoma is a tumor histologically characterized by polymorphic cells comprising mainly spindle-shaped cells that proliferate and present with an...
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StartPage 170
SubjectTerms 下顎歯肉
甲状腺
紡錘細胞癌
Title 甲状腺転移をきたした下顎歯肉紡錘細胞癌の1例
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