線維性異形成症部に生じた下顎骨骨折の治療を行った1例

Fibrous dysplasia is a benign bone disease characterized by fibro-osseous lesions consisting of metaplastic fibrous tissue with immature bone remodeling. It is now thought to be caused by Gs α somatic mutation leading to abnormal development of the osteogenic mesenchymal tissue. In fibrous dysplasia...

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Published in日本口腔外科学会雑誌 Vol. 60; no. 4; pp. 209 - 213
Main Authors 三島, 清香, 別所, 和久, 磯部, 悠, 池野, 正幸, 高橋, 克, 北本, 幸恵
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.04.2014
Subjects
線維性異形成症
骨折
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.60.209

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Abstract Fibrous dysplasia is a benign bone disease characterized by fibro-osseous lesions consisting of metaplastic fibrous tissue with immature bone remodeling. It is now thought to be caused by Gs α somatic mutation leading to abnormal development of the osteogenic mesenchymal tissue. In fibrous dysplasia, a majority of fractures occur in femur and tibia, and mandibular fracture is extremely rare. We report a case of mandibular fracture in fibrous dysplasia arising in a 19-year-old man. The patient underwent open reduction and fixation of the mandibular fracture. He had a good functional occlusion after surgery.
AbstractList Fibrous dysplasia is a benign bone disease characterized by fibro-osseous lesions consisting of metaplastic fibrous tissue with immature bone remodeling. It is now thought to be caused by Gs α somatic mutation leading to abnormal development of the osteogenic mesenchymal tissue. In fibrous dysplasia, a majority of fractures occur in femur and tibia, and mandibular fracture is extremely rare. We report a case of mandibular fracture in fibrous dysplasia arising in a 19-year-old man. The patient underwent open reduction and fixation of the mandibular fracture. He had a good functional occlusion after surgery.
Author 別所, 和久
北本, 幸恵
池野, 正幸
高橋, 克
三島, 清香
磯部, 悠
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  fullname: 北本, 幸恵
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References 4) 坂本昭夫，岩本幸之：GNAS1遺伝子変異の有無による線維性異形成と骨線維性異形成の鑑別．骨・関節・靭帯 15: 65-68, 2002.
6) Rosai J and Ackerman L : Surgical Pathology, Ninth Edition, mosby Co, St. Louis, 2192-2194, 2004.
13) 古屋光太郎：Fibrous dysplasiaとその類似疾患．日整会誌 43: 151-174, 1969.
21) Robert PS, Ernesto I, et al : The surgical management of fibrous dysplasia of bone. Orphanet Journal of Rare Diseases 7, 2012.
17) 波利井清紀：形成外科ADVANCE シリーズI - 5 頭蓋顔面外科．最新の進歩．第2版， 克誠堂出版， 東京，2007, 297-406頁
9) Riminucci M, Robey PG, et al : Skeletal progenitors and the GNAS Gene:fibrous dysplasia of bone read throught stem cells. J Mol Endocrinol 45: 335-634, 2010.
1) Weinstein LS, Shenker A, et al : Activating Mutations of the Stimulatory G Protein in the McCune-Albright Syndrome. N Engl J Med 325: 1688-1695, 1991.
2) Cohen M and Howell R : Etiology of fibrous dysplasia and McCune-Albright syndrome. Int J Oral Maxillofac Surg 28: 366-371, 1999.
12) 林　輝嘉，赤松栄之，他：68歳女性で下顎骨線維性骨異形成症と診断された1例．日口診誌 23: 79-84, 2010.
16) Chen Y and Moordhoof M : Treatment of cranio maxilla facial fibous dysplasia : How early and how extensive?. Plast Reconstr Surg 86: 835-844, 1990.
20) Matthew R and William F : Fibrous Dysplasia. Pathophysiology, Evaluation, and Treatment. J Bone Joint Surg 87: 1848-1864, 2005.
22) Al-Mouazzen L, Rajakulendran K, et al : Fibrous dysplasia, shepherd's crook deformity and an intracapsular femoral neck fracture 8: 187-191, 2013.
24) 伊藤雄也，吉原愛雄，他：大腿骨頭下に病的骨折を生じたMc-Cune-Albright症候群の手術例．関東整災外会誌 41: 317-322, 2010.
3) Lichtenstein L : Polyostotic fibrous dysplasia. Arch Surg 36: 874-898, 1938.
23) 片桐　聡，熊本久大，他：大腿骨転子下骨折を伴い内反股が進行したMcCune-Albright症候群の一例． 昭和医会誌 69: 194-197, 2009.
15) Barnes L, Verbin R, et al : Disease of the bones and joints.Surgical pathology of head and neck, Mercel Dekker, New York-Basel 17: 920-926, 1985.
11) Sakata T, Takahashi K, et al : Repeated surgical reduction of the mandible over a 19-year period due to fibrous dysplasia : A case report.Asian Journal of Oral and Maxillofacial Surgery 22: 33-36, 2010.
8) Weinstein LS, Chen M, et al : Gs （alpha） mutations and imprinting defects in human disease. Ann NY Acad Sci 968: 173-197, 2002.
5) 山本威久，大薗恵一：Gs α遺伝子の活性型変異とMcCune-Albright症候群の骨病変．医学のあゆみ 192: 662-666, 2000.
18) Conejero J, Babbitt R, et al : Management of incidental fibrous dysplasia of the maxilla in a patient with facial fractures.J Craniofac Surg 18: 1463-1464, 2007.
19) Leet AI, Chebli C, et al : Fracture incidence in polyostotic fibro. J Bone Miner Res 19: 571-577, 2003.
7) Bianco P, Riminucci M, et al : Mutations of the GNAS1 Gene, Stromal Cell Dysfunction, and Osteomalacic Changes in Non-McCune-Albright Fibrous Dysplasia of Bone. J Bone Miner Res 15: 120-128, 2000.
10) 平田　功，別所和久，他：抗BMP-2抗体を用いて免疫組織化学的検索を行った線維性骨異形成症の1例．日口外誌 45: 712-714, 1999.
14) Jundt G : Fibrous dysplasia.In Barnes L, Eveson JW, eds; WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon, 2005, p321-322.
References_xml – reference: 14) Jundt G : Fibrous dysplasia.In Barnes L, Eveson JW, eds; WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon, 2005, p321-322.
– reference: 19) Leet AI, Chebli C, et al : Fracture incidence in polyostotic fibro. J Bone Miner Res 19: 571-577, 2003.
– reference: 18) Conejero J, Babbitt R, et al : Management of incidental fibrous dysplasia of the maxilla in a patient with facial fractures.J Craniofac Surg 18: 1463-1464, 2007.
– reference: 16) Chen Y and Moordhoof M : Treatment of cranio maxilla facial fibous dysplasia : How early and how extensive?. Plast Reconstr Surg 86: 835-844, 1990.
– reference: 1) Weinstein LS, Shenker A, et al : Activating Mutations of the Stimulatory G Protein in the McCune-Albright Syndrome. N Engl J Med 325: 1688-1695, 1991.
– reference: 7) Bianco P, Riminucci M, et al : Mutations of the GNAS1 Gene, Stromal Cell Dysfunction, and Osteomalacic Changes in Non-McCune-Albright Fibrous Dysplasia of Bone. J Bone Miner Res 15: 120-128, 2000.
– reference: 8) Weinstein LS, Chen M, et al : Gs （alpha） mutations and imprinting defects in human disease. Ann NY Acad Sci 968: 173-197, 2002.
– reference: 4) 坂本昭夫，岩本幸之：GNAS1遺伝子変異の有無による線維性異形成と骨線維性異形成の鑑別．骨・関節・靭帯 15: 65-68, 2002.
– reference: 6) Rosai J and Ackerman L : Surgical Pathology, Ninth Edition, mosby Co, St. Louis, 2192-2194, 2004.
– reference: 10) 平田　功，別所和久，他：抗BMP-2抗体を用いて免疫組織化学的検索を行った線維性骨異形成症の1例．日口外誌 45: 712-714, 1999.
– reference: 2) Cohen M and Howell R : Etiology of fibrous dysplasia and McCune-Albright syndrome. Int J Oral Maxillofac Surg 28: 366-371, 1999.
– reference: 21) Robert PS, Ernesto I, et al : The surgical management of fibrous dysplasia of bone. Orphanet Journal of Rare Diseases 7, 2012.
– reference: 11) Sakata T, Takahashi K, et al : Repeated surgical reduction of the mandible over a 19-year period due to fibrous dysplasia : A case report.Asian Journal of Oral and Maxillofacial Surgery 22: 33-36, 2010.
– reference: 3) Lichtenstein L : Polyostotic fibrous dysplasia. Arch Surg 36: 874-898, 1938.
– reference: 15) Barnes L, Verbin R, et al : Disease of the bones and joints.Surgical pathology of head and neck, Mercel Dekker, New York-Basel 17: 920-926, 1985.
– reference: 17) 波利井清紀：形成外科ADVANCE シリーズI - 5 頭蓋顔面外科．最新の進歩．第2版， 克誠堂出版， 東京，2007, 297-406頁．
– reference: 9) Riminucci M, Robey PG, et al : Skeletal progenitors and the GNAS Gene:fibrous dysplasia of bone read throught stem cells. J Mol Endocrinol 45: 335-634, 2010.
– reference: 20) Matthew R and William F : Fibrous Dysplasia. Pathophysiology, Evaluation, and Treatment. J Bone Joint Surg 87: 1848-1864, 2005.
– reference: 5) 山本威久，大薗恵一：Gs α遺伝子の活性型変異とMcCune-Albright症候群の骨病変．医学のあゆみ 192: 662-666, 2000.
– reference: 24) 伊藤雄也，吉原愛雄，他：大腿骨頭下に病的骨折を生じたMc-Cune-Albright症候群の手術例．関東整災外会誌 41: 317-322, 2010.
– reference: 12) 林　輝嘉，赤松栄之，他：68歳女性で下顎骨線維性骨異形成症と診断された1例．日口診誌 23: 79-84, 2010.
– reference: 13) 古屋光太郎：Fibrous dysplasiaとその類似疾患．日整会誌 43: 151-174, 1969.
– reference: 22) Al-Mouazzen L, Rajakulendran K, et al : Fibrous dysplasia, shepherd's crook deformity and an intracapsular femoral neck fracture 8: 187-191, 2013.
– reference: 23) 片桐　聡，熊本久大，他：大腿骨転子下骨折を伴い内反股が進行したMcCune-Albright症候群の一例． 昭和医会誌 69: 194-197, 2009.
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Snippet Fibrous dysplasia is a benign bone disease characterized by fibro-osseous lesions consisting of metaplastic fibrous tissue with immature bone remodeling. It is...
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StartPage 209
SubjectTerms 線維性異形成症
骨折
Title 線維性異形成症部に生じた下顎骨骨折の治療を行った1例
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