筋突起前縁部に発生した滑膜肉腫の1例

Synovial sarcoma, a malignant tumor with a poor prognosis, most commonly occurs near limb joints and has relatively high rates of hematogenous metastases to the lungs and other organs. While synovial sarcoma very rarely arises in the head and neck region, occurrence in sites unrelated to joints, suc...

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Published in日本口腔外科学会雑誌 Vol. 63; no. 6; pp. 298 - 303
Main Authors 福原, 聖代, 増田, 千恵子, 岡田, とし江, 堀江, 彰久, 是恒, 秀一, 大橋, 瑞己
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.06.2017
Subjects
滑膜肉腫
筋突起
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.63.298

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Abstract Synovial sarcoma, a malignant tumor with a poor prognosis, most commonly occurs near limb joints and has relatively high rates of hematogenous metastases to the lungs and other organs. While synovial sarcoma very rarely arises in the head and neck region, occurrence in sites unrelated to joints, such as the tongue and pharynx, has been reported. We report a rare case of synovial sarcoma on the anterior border of the coronoid process. The patient was a 31-year-old man who was referred to our department because of rightcheek swelling and tenderness. Due to the severity of the pain and swelling, he was hospitalized for biopsy, Because malignancy was pathologically detected on biopsy, wide resection of the soft tissue tumor, including the right mandibular coronoid process, was therefore performed with the patient under general anesthesia. Reconstruction was preformed using a mandibular reconstruction plate and a left radial forearm flap. Synovial sarcoma was definitively diagnosed on histopathological examination of the surgical specimen. Five cycles of doxorubicin/ifosfamide/mesna (AIM) therapy were postoperatively administered in the hematology department. There has been no sign of recurrence or metastasis for 24 months postoperatively.
AbstractList Synovial sarcoma, a malignant tumor with a poor prognosis, most commonly occurs near limb joints and has relatively high rates of hematogenous metastases to the lungs and other organs. While synovial sarcoma very rarely arises in the head and neck region, occurrence in sites unrelated to joints, such as the tongue and pharynx, has been reported. We report a rare case of synovial sarcoma on the anterior border of the coronoid process. The patient was a 31-year-old man who was referred to our department because of rightcheek swelling and tenderness. Due to the severity of the pain and swelling, he was hospitalized for biopsy, Because malignancy was pathologically detected on biopsy, wide resection of the soft tissue tumor, including the right mandibular coronoid process, was therefore performed with the patient under general anesthesia. Reconstruction was preformed using a mandibular reconstruction plate and a left radial forearm flap. Synovial sarcoma was definitively diagnosed on histopathological examination of the surgical specimen. Five cycles of doxorubicin/ifosfamide/mesna (AIM) therapy were postoperatively administered in the hematology department. There has been no sign of recurrence or metastasis for 24 months postoperatively.
Author 大橋, 瑞己
増田, 千恵子
福原, 聖代
岡田, とし江
堀江, 彰久
是恒, 秀一
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19) NCCN ガイドライン2014．臨床研究情報センター．http://www.tri-kobe.org/nccn/index.html. Accessed April 17, 2015.
21) Tierney JF : Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. The Lancet 350: 1647-1654, 1997.
6) 音田　貢，岡本和己，他：オトガイ部に生じた滑膜肉腫の1例．日口外誌 42: 521-523, 1996.
3) Hanada T, Iwashita M, et al : Synovial sarcoma in the parapharyngeal space : case report and review of the literature. Auris Nasus Larynx 26: 91-94, 1999.
5) 水城春美，戸高勝之，他：翼突下顎隙に発生した滑膜肉腫の1例：口腔腫瘍 1: 35-40, 1989.
17) FNCLCC (Fedration Nationale des Centres de Lutte Contre le Cancer)．http://www.unicancer.fr/. Accessed April 14, 2015.
12) 村瀬樹太郎，入江健夫，他：咀嚼筋間隙に発生した滑膜肉腫の1例．日画像医誌 28: 35-43, 2010.
18) 軟部腫瘍診療ガイドライン2012. 日本整形外科学会．http://minds.jcqhc.or.jp/n/medical. Accessed April 4, 2015.
13) 清水郁夫，武田　航，他：AIM療法および局所放射線照射により加療し長期寛解を得ているLangerhans細胞肉腫．臨床血液 53: 1911-1915, 2012.
8) Nomura F and Kishimoto S : Synovial sarcoma of the temporomandibular joint and infratemporal fossa．Auris Nasus Larynx 41: 572-575, 2014.
10) 坂田智恵，木下俊文，他：顎下部に発生した滑膜肉腫の1例．日本医放会誌 65: 279-280, 2005.
9) 平井伸彦，門前芳夫，他：口腔底原発のSynovial Sarcomaの1例．日本医放会誌 60: 340-341, 2000.
11) Bukawa H, Kawabata A, et al : Monophasic epithelial synovial sarcoma arising in the temporomandibular joint : Int J Oral Maxillofac Surg 36: 762-765, 2007.
15) Terasaki H, Niki T, et al : Japanese Journal of Clinical Oncology, Oxford Journals Vol.31: 212-216, 2001.
14) Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma : Wakamatsu T， Naka N, et al : Cancer Science. Japanese Cancer Association 105: 1124-1134, 2014.
22) 広田茂明，内田淳正，他：滑膜肉腫の治療成績．日臨整誌 23: 1173-1178, 1988.
7) 平山方俊，高橋廣臣，他：側頭下窩に発生した滑膜肉腫．耳鼻頭頸 72: 491-495, 2000.
1) 前田睦浩，青木虎吉，他：滑膜肉腫の臨床病理学的検討．整形・災害外科 26: 891-901, 1983.
2) 荒井孝和，川口智義，他：滑膜肉腫の臨床病理学的検討．日整会誌 49: 253-271, 1975.
20) ドキソルビシン（骨・軟部腫瘍）．厚生労働省．http://www.mhlw.go.jp/shingi/2004/05/dl/s0521-5d.pdf. Accessed April 20, 2015.
16) 久岡正典，橋本　洋，他：軟部腫瘍におけるキメラ遺伝子．日臨細胞会誌 38: 394-397, 2006.
References_xml – reference: 3) Hanada T, Iwashita M, et al : Synovial sarcoma in the parapharyngeal space : case report and review of the literature. Auris Nasus Larynx 26: 91-94, 1999.
– reference: 20) ドキソルビシン（骨・軟部腫瘍）．厚生労働省．http://www.mhlw.go.jp/shingi/2004/05/dl/s0521-5d.pdf. Accessed April 20, 2015.
– reference: 8) Nomura F and Kishimoto S : Synovial sarcoma of the temporomandibular joint and infratemporal fossa．Auris Nasus Larynx 41: 572-575, 2014.
– reference: 11) Bukawa H, Kawabata A, et al : Monophasic epithelial synovial sarcoma arising in the temporomandibular joint : Int J Oral Maxillofac Surg 36: 762-765, 2007.
– reference: 13) 清水郁夫，武田　航，他：AIM療法および局所放射線照射により加療し長期寛解を得ているLangerhans細胞肉腫．臨床血液 53: 1911-1915, 2012.
– reference: 15) Terasaki H, Niki T, et al : Japanese Journal of Clinical Oncology, Oxford Journals Vol.31: 212-216, 2001.
– reference: 1) 前田睦浩，青木虎吉，他：滑膜肉腫の臨床病理学的検討．整形・災害外科 26: 891-901, 1983.
– reference: 5) 水城春美，戸高勝之，他：翼突下顎隙に発生した滑膜肉腫の1例：口腔腫瘍 1: 35-40, 1989.
– reference: 7) 平山方俊，高橋廣臣，他：側頭下窩に発生した滑膜肉腫．耳鼻頭頸 72: 491-495, 2000.
– reference: 14) Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma : Wakamatsu T， Naka N, et al : Cancer Science. Japanese Cancer Association 105: 1124-1134, 2014.
– reference: 4) 中田和義，中村智次，他：滑膜肉腫の組織化学．Journal of Joint Surgery, 5: 91-100, 1986.
– reference: 12) 村瀬樹太郎，入江健夫，他：咀嚼筋間隙に発生した滑膜肉腫の1例．日画像医誌 28: 35-43, 2010.
– reference: 6) 音田　貢，岡本和己，他：オトガイ部に生じた滑膜肉腫の1例．日口外誌 42: 521-523, 1996.
– reference: 10) 坂田智恵，木下俊文，他：顎下部に発生した滑膜肉腫の1例．日本医放会誌 65: 279-280, 2005.
– reference: 16) 久岡正典，橋本　洋，他：軟部腫瘍におけるキメラ遺伝子．日臨細胞会誌 38: 394-397, 2006.
– reference: 21) Tierney JF : Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. The Lancet 350: 1647-1654, 1997.
– reference: 9) 平井伸彦，門前芳夫，他：口腔底原発のSynovial Sarcomaの1例．日本医放会誌 60: 340-341, 2000.
– reference: 17) FNCLCC (Fedration Nationale des Centres de Lutte Contre le Cancer)．http://www.unicancer.fr/. Accessed April 14, 2015.
– reference: 22) 広田茂明，内田淳正，他：滑膜肉腫の治療成績．日臨整誌 23: 1173-1178, 1988.
– reference: 2) 荒井孝和，川口智義，他：滑膜肉腫の臨床病理学的検討．日整会誌 49: 253-271, 1975.
– reference: 18) 軟部腫瘍診療ガイドライン2012. 日本整形外科学会．http://minds.jcqhc.or.jp/n/medical. Accessed April 4, 2015.
– reference: 19) NCCN ガイドライン2014．臨床研究情報センター．http://www.tri-kobe.org/nccn/index.html. Accessed April 17, 2015.
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Snippet Synovial sarcoma, a malignant tumor with a poor prognosis, most commonly occurs near limb joints and has relatively high rates of hematogenous metastases to...
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SubjectTerms 滑膜肉腫
筋突起
Title 筋突起前縁部に発生した滑膜肉腫の1例
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