歯牙腫を伴った象牙質形成性幻影細胞腫の1例

Dentinogenic ghost cell tumor（DGCT）is a rare benign odontogenic neoplasm classified into intraosseous and extraosseous types. The intraosseous type has been reported to feature significant osseous invasion and a high recurrence rate. Some reported DGCTs have been associated with odontoma. We report...

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Published in日本口腔外科学会雑誌 Vol. 70; no. 5; pp. 203 - 207
Main Authors 井上, 亮, 柏木, まりな, 渡邉, 拓磨, 渡辺, 猛寛, 井上, 史基, 白井, 陽子
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本口腔外科学会 20.05.2024
Subjects
歯牙腫
石灰化歯原性囊胞
象牙質形成性幻影細胞腫
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.70.203

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Abstract Dentinogenic ghost cell tumor（DGCT）is a rare benign odontogenic neoplasm classified into intraosseous and extraosseous types. The intraosseous type has been reported to feature significant osseous invasion and a high recurrence rate. Some reported DGCTs have been associated with odontoma. We report a case of DGCT in a 12-year-old female referred to our department by a local dental clinic after a radiopaque lesion was identified in the right maxilla by panoramic radiography. Intraoral examination showed delayed eruption of the right maxillary central incisor with gingival swelling. Computed tomography demonstrated tooth-like structures within the right maxilla, surrounded by a low-density area with a well-defined boundary. The area involved the crown of the right maxillary central incisor. The clinical diagnosis was calcifying odontogenic cyst associated with odontoma; therefore, surgical enucleation was performed under general anesthesia. The enucleated specimen measured approximately 20 mm in diameter, had a solid consistency, and contained several tooth-like structures. Histopathology showed the presence of ghost cells and odontogenic epithelium resembling enamel epithelium. The histopathological diagnosis was DGCT, and the tooth-like structures were confirmed as odontoma. Three years after surgery, the patient has had no tumor recurrence. Nonetheless, close follow-up is being continued.
AbstractList Dentinogenic ghost cell tumor（DGCT）is a rare benign odontogenic neoplasm classified into intraosseous and extraosseous types. The intraosseous type has been reported to feature significant osseous invasion and a high recurrence rate. Some reported DGCTs have been associated with odontoma. We report a case of DGCT in a 12-year-old female referred to our department by a local dental clinic after a radiopaque lesion was identified in the right maxilla by panoramic radiography. Intraoral examination showed delayed eruption of the right maxillary central incisor with gingival swelling. Computed tomography demonstrated tooth-like structures within the right maxilla, surrounded by a low-density area with a well-defined boundary. The area involved the crown of the right maxillary central incisor. The clinical diagnosis was calcifying odontogenic cyst associated with odontoma; therefore, surgical enucleation was performed under general anesthesia. The enucleated specimen measured approximately 20 mm in diameter, had a solid consistency, and contained several tooth-like structures. Histopathology showed the presence of ghost cells and odontogenic epithelium resembling enamel epithelium. The histopathological diagnosis was DGCT, and the tooth-like structures were confirmed as odontoma. Three years after surgery, the patient has had no tumor recurrence. Nonetheless, close follow-up is being continued.
Author 柏木, まりな
渡辺, 猛寛
渡邉, 拓磨
井上, 亮
白井, 陽子
井上, 史基
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  fullname: 白井, 陽子
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References 17) Okui T, Morioka R, et al : A rare case of dentinogenic ghost cell tumor with concomitant odontoma. Clin Case Rep 11: e7442, 2023.
23) Ramaglia L, Esposito D, et al : Dentinogenic ghost cell tumor. histopathology and clinical aspects in pediatric age. Minerva Stomatol 61: 509-517, 2012.
30) Liu G, Li J, et al : Peripheral dentinogenic ghost cell tumor of the ethmoid sinus: a case report. Medicine 99: 2020. Available at: https://doi.org/10.1097/md.0000000000018896. Accessed July 3, 2023.
6) Kokubun K, Yamamoto K, et al : Frequency of Odontogenic tumors: a single center study of 1089 cases in Japan and literature review. Head and Neck Pathology 16: 494-502, 2022.
28) Natani A, Borah S, et al : Dentinogenic ghost cell tumor of mandible in a pediatric patient with dysplastic changes. J Clin Pediatr Dent 13: 119-121, 2020.
29) Patankar S, Khetan P, et al : Dentinogenic ghost cell tumor: a case report. World J Clin Oncol 10: 192-200, 2019.
7) Escobar E, Velenzuela FG, et al : Odontogenic tumours in a Chilean population: a retrospective study of 544 cases based on 2022 WHO classification. Med Oral Patol Oral Cir Bucal 28: e596-606, 2023.
9) Buchner A : The central calcifying odontogenic cyct:an analysis of 215 cases. J Oral Maxillofac Surg 49: 330-339, 1991.
20) Gomes IP, Bastos VC, et al : The molecular basis of odontogenic cysts and tumours. J Oral Pathol Med 52: 351-356, 2023.
26) Arora S, Urs AB, et al : An expansile well-defined radiolucency in anterior mandible : Case presentation with treatment approach and literature update. Gulf J Oncolog 1: 77-81, 2017.
8) 島末　洋，久保薗和美，他：92歳の女性に生じた石灰化囊胞性歯原性腫瘍の１例．日口外誌 58: 327-331, 2012.
16) Urs AB, Jot K, et al : Dentinogenic ghost cell tumor associated with Odontoma: a unique histopathological entity and its surgical management: J Clin Pediat Dent 46: 146-151, 2022.
21) Oh KY, Hong SD, et al : Adenoid ameloblastoma shares clinical, histologic, and molecular features with dentinogenic ghost cell tumor: the histologic spectrum of WNT pathway-altered benign odontogenic tomors. Mod Pathol 36: 2023. Available at: https://doi.org/10.1016/j.modpat.2022.100051. Accessed November 10, 2023.
12) Alzaid MA, Kavarodi AM, et al : Recurrent dentinogenic ghost cell tumor: a case report. Am J Case Rep 23: e936787, 2022.
10) Sun G, Huang X, et al : The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg 38: 1179-1183, 2009.
32) Ravi B, Kamath G, et al : Dentinogenic ghost cell tumor-a rare case report.J Stomatol Oral Maxillofac Surg 121: 186-188, 2020.
14) Bavle RM, Muniswamappa S, et al : Variations in aggressive and indolent behaviour of central dentinogenic ghost cell tumor. Case Rep Dent 2020: 2020. Available at: https://doi.org/10.1155/2020/8837507. Accessed July 3, 2023.
19) Noda Y, Ohe C, et al : Useful diagnostic histogenetic features of ectopic odontogenic ghost cell tumors. BMC Oral Health 22: 134, 2022.
25) Yun KI, Lee JA, et al : Dentinogenic ghost cell tumors. J Oral Maxillofac Surg 65: 1816-1819, 2007.
18) Gwartzman B, Trinh K, et al : Dentinogenic ghost cell tumor associated with odontoma: report of a rare case and review of literature. Quintessence International 54: 8, 2023.
24) Cicciu M, Herford AS, et al : Protein-signaled guided bone regeneration using titanium mesh and rh-BMP2 in oral surgery: a case report involving left mandibular reconstruction after tumor resection. Open Dent J 6: 51-55, 2012.
5) Franklin JRB, Vieira EL, et al : Epidemiological evaluation of jaw cysts according to the new WHO classification: a 30-year retrospective analysis. Braz Oral Res 35: e129, 2021.
22) Park HR, Min JH, et al : Distant metastasis of intraosseous dentinogenic ghost cell tumour to the donor site of a bone graft. Dentomaxillofac Radiol 42: 2013.
2) 武田泰典，高田　隆：WHO による歯原性腫瘍の新たな組織分類とそれに関連する上皮性囊胞について．日口外誌 52: 54-61, 2006.
3) El-Naggar AK, Chan JK, et al : WHO claasification of tumours of the head and neck. 4th ed. IARC Press; 203-60, 2017.
13) Satish V, Prabhadevi MC, et al : Odontome: a brief overview. Int J Clin Pediatr Dent 4: 177-185, 2011.
15) Hogge M, Velez I, et al : Ghost cell odontogenic tumor associated with Odontoma-report of two rare cases. J Clin Pediatr Dent 36: 373-376, 2012.
31) Agrawal Y, Naidu GN, et al : Dentinogenic ghost cell tumor-a rare case report with review of literature. Quant Imaging Med Surg 7: 598-604, 2017.
27) Tekkesin MS, Erdem MA, et al : Intraosseous and extraosseous variants of dentinogenic ghost cell tumor: two case reports. J Istanb Univ Fac Dent 49: 56-60, 2015.
1) de Arruda JAA, Monterio JLGC, et al : Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontgenic carcinoma. J Oral Pathol Med 47: 721-30, 2018.
4) Praetrius F and Ledesma-Montes C : Calcifying cyctic odontogenic tumor, Dentinogenic ghost cell tumor． In Barnes L, Eveson JW, eds；WHO Classification of tumors, Pathology and Genetics of Head and Neck Tumors. IARC Press, Lyon, 2005, p313-314.
11) Juneja M and George J : Dentinogenic ghost cell tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107: 17-22, 2009.
References_xml – reference: 24) Cicciu M, Herford AS, et al : Protein-signaled guided bone regeneration using titanium mesh and rh-BMP2 in oral surgery: a case report involving left mandibular reconstruction after tumor resection. Open Dent J 6: 51-55, 2012.
– reference: 23) Ramaglia L, Esposito D, et al : Dentinogenic ghost cell tumor. histopathology and clinical aspects in pediatric age. Minerva Stomatol 61: 509-517, 2012.
– reference: 26) Arora S, Urs AB, et al : An expansile well-defined radiolucency in anterior mandible : Case presentation with treatment approach and literature update. Gulf J Oncolog 1: 77-81, 2017.
– reference: 11) Juneja M and George J : Dentinogenic ghost cell tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107: 17-22, 2009.
– reference: 10) Sun G, Huang X, et al : The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg 38: 1179-1183, 2009.
– reference: 14) Bavle RM, Muniswamappa S, et al : Variations in aggressive and indolent behaviour of central dentinogenic ghost cell tumor. Case Rep Dent 2020: 2020. Available at: https://doi.org/10.1155/2020/8837507. Accessed July 3, 2023.
– reference: 29) Patankar S, Khetan P, et al : Dentinogenic ghost cell tumor: a case report. World J Clin Oncol 10: 192-200, 2019.
– reference: 27) Tekkesin MS, Erdem MA, et al : Intraosseous and extraosseous variants of dentinogenic ghost cell tumor: two case reports. J Istanb Univ Fac Dent 49: 56-60, 2015.
– reference: 28) Natani A, Borah S, et al : Dentinogenic ghost cell tumor of mandible in a pediatric patient with dysplastic changes. J Clin Pediatr Dent 13: 119-121, 2020.
– reference: 31) Agrawal Y, Naidu GN, et al : Dentinogenic ghost cell tumor-a rare case report with review of literature. Quant Imaging Med Surg 7: 598-604, 2017.
– reference: 20) Gomes IP, Bastos VC, et al : The molecular basis of odontogenic cysts and tumours. J Oral Pathol Med 52: 351-356, 2023.
– reference: 1) de Arruda JAA, Monterio JLGC, et al : Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontgenic carcinoma. J Oral Pathol Med 47: 721-30, 2018.
– reference: 8) 島末　洋，久保薗和美，他：92歳の女性に生じた石灰化囊胞性歯原性腫瘍の１例．日口外誌 58: 327-331, 2012.
– reference: 4) Praetrius F and Ledesma-Montes C : Calcifying cyctic odontogenic tumor, Dentinogenic ghost cell tumor． In Barnes L, Eveson JW, eds；WHO Classification of tumors, Pathology and Genetics of Head and Neck Tumors. IARC Press, Lyon, 2005, p313-314.
– reference: 9) Buchner A : The central calcifying odontogenic cyct:an analysis of 215 cases. J Oral Maxillofac Surg 49: 330-339, 1991.
– reference: 18) Gwartzman B, Trinh K, et al : Dentinogenic ghost cell tumor associated with odontoma: report of a rare case and review of literature. Quintessence International 54: 8, 2023.
– reference: 3) El-Naggar AK, Chan JK, et al : WHO claasification of tumours of the head and neck. 4th ed. IARC Press; 203-60, 2017.
– reference: 25) Yun KI, Lee JA, et al : Dentinogenic ghost cell tumors. J Oral Maxillofac Surg 65: 1816-1819, 2007.
– reference: 21) Oh KY, Hong SD, et al : Adenoid ameloblastoma shares clinical, histologic, and molecular features with dentinogenic ghost cell tumor: the histologic spectrum of WNT pathway-altered benign odontogenic tomors. Mod Pathol 36: 2023. Available at: https://doi.org/10.1016/j.modpat.2022.100051. Accessed November 10, 2023.
– reference: 22) Park HR, Min JH, et al : Distant metastasis of intraosseous dentinogenic ghost cell tumour to the donor site of a bone graft. Dentomaxillofac Radiol 42: 2013.
– reference: 13) Satish V, Prabhadevi MC, et al : Odontome: a brief overview. Int J Clin Pediatr Dent 4: 177-185, 2011.
– reference: 30) Liu G, Li J, et al : Peripheral dentinogenic ghost cell tumor of the ethmoid sinus: a case report. Medicine 99: 2020. Available at: https://doi.org/10.1097/md.0000000000018896. Accessed July 3, 2023.
– reference: 16) Urs AB, Jot K, et al : Dentinogenic ghost cell tumor associated with Odontoma: a unique histopathological entity and its surgical management: J Clin Pediat Dent 46: 146-151, 2022.
– reference: 2) 武田泰典，高田　隆：WHO による歯原性腫瘍の新たな組織分類とそれに関連する上皮性囊胞について．日口外誌 52: 54-61, 2006.
– reference: 6) Kokubun K, Yamamoto K, et al : Frequency of Odontogenic tumors: a single center study of 1089 cases in Japan and literature review. Head and Neck Pathology 16: 494-502, 2022.
– reference: 7) Escobar E, Velenzuela FG, et al : Odontogenic tumours in a Chilean population: a retrospective study of 544 cases based on 2022 WHO classification. Med Oral Patol Oral Cir Bucal 28: e596-606, 2023.
– reference: 12) Alzaid MA, Kavarodi AM, et al : Recurrent dentinogenic ghost cell tumor: a case report. Am J Case Rep 23: e936787, 2022.
– reference: 15) Hogge M, Velez I, et al : Ghost cell odontogenic tumor associated with Odontoma-report of two rare cases. J Clin Pediatr Dent 36: 373-376, 2012.
– reference: 19) Noda Y, Ohe C, et al : Useful diagnostic histogenetic features of ectopic odontogenic ghost cell tumors. BMC Oral Health 22: 134, 2022.
– reference: 5) Franklin JRB, Vieira EL, et al : Epidemiological evaluation of jaw cysts according to the new WHO classification: a 30-year retrospective analysis. Braz Oral Res 35: e129, 2021.
– reference: 17) Okui T, Morioka R, et al : A rare case of dentinogenic ghost cell tumor with concomitant odontoma. Clin Case Rep 11: e7442, 2023.
– reference: 32) Ravi B, Kamath G, et al : Dentinogenic ghost cell tumor-a rare case report.J Stomatol Oral Maxillofac Surg 121: 186-188, 2020.
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Snippet Dentinogenic ghost cell tumor（DGCT）is a rare benign odontogenic neoplasm classified into intraosseous and extraosseous types. The intraosseous type has been...
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SubjectTerms 歯牙腫
石灰化歯原性囊胞
象牙質形成性幻影細胞腫
Title 歯牙腫を伴った象牙質形成性幻影細胞腫の1例
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