被膜に著明な石灰化と骨形成を認めた顎下腺多形腺腫の1例

We report a rare case of pleomorphic adenoma with dystrophic calcification and bone formation in the capsule of the submandibular gland. A 48-year-old man visited our hospital because of a mass in the submandibular gland. CT and FDG-PET images showed a well-defined round mass 20 mm in diameter in th...

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Published in日本口腔外科学会雑誌 Vol. 58; no. 4; pp. 217 - 221
Main Authors 岩井, 聡一, 雨河, 茂樹, 米川, 敦子, 小川, 芙美, 永川, 賢治, 大西, 徹郎
Format Journal Article
LanguageJapanese
Published 社団法人 日本口腔外科学会 20.04.2012
Subjects
唾液腺腫瘍
多形腺腫
異栄養性石灰化
骨形成
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.58.217

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Abstract We report a rare case of pleomorphic adenoma with dystrophic calcification and bone formation in the capsule of the submandibular gland. A 48-year-old man visited our hospital because of a mass in the submandibular gland. CT and FDG-PET images showed a well-defined round mass 20 mm in diameter in the right submandibular gland. It was covered with a calcified substance. The clinical diagnosis was a submandibular tumor, and the patient underwent extirpation of the right submandibular gland. The tumor was histopathologically diagnosed as a pleomorphic adenoma. Histopathologically, the tumor was composed of epithelial and mesenchymal structures including myxomatous and chondroid areas. Dystrophic calcification was observed in the entire periphery of the tumor, and bone formation was seen in contact with the calcified structure.
AbstractList We report a rare case of pleomorphic adenoma with dystrophic calcification and bone formation in the capsule of the submandibular gland. A 48-year-old man visited our hospital because of a mass in the submandibular gland. CT and FDG-PET images showed a well-defined round mass 20 mm in diameter in the right submandibular gland. It was covered with a calcified substance. The clinical diagnosis was a submandibular tumor, and the patient underwent extirpation of the right submandibular gland. The tumor was histopathologically diagnosed as a pleomorphic adenoma. Histopathologically, the tumor was composed of epithelial and mesenchymal structures including myxomatous and chondroid areas. Dystrophic calcification was observed in the entire periphery of the tumor, and bone formation was seen in contact with the calcified structure.
Author 岩井, 聡一
小川, 芙美
雨河, 茂樹
永川, 賢治
米川, 敦子
大西, 徹郎
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  fullname: 雨河, 茂樹
  organization: 市立池田病院歯科口腔外科
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  fullname: 米川, 敦子
  organization: 大阪大学大学院歯学研究科顎口腔病因病態制御学講座口腔外科学第二教室
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  fullname: 小川, 芙美
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  fullname: 永川, 賢治
  organization: 市立池田病院歯科口腔外科
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  fullname: 大西, 徹郎
  organization: 市立池田病院歯科口腔外科
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References 22) Kusafuka K, Yamaguchi A, et al : Expression of bone matrix proteins, Osteonectin and Osteopontin, in salivary pleomorphic adenomas. Pathol Res Pract 195: 733-739, 1999.
10) Yates PO and Paget GE : A mixed tumor of salivary gland showing bone formation, with a histochemical study of the tumor mucoids. J Pathol Bacteriol 64: 881-887, 1952.
18) 渡邊武寛, 清水貴子, 他：骨組織形成を伴う多形性腺腫の1症例. 松本歯学 32: 133-137, 2006.
4) 石川梧郎, 秋吉正豊：口腔病理学II. 改訂版, 永末書店, 京都, 1982, 716-762頁.
1) 内山英樹, 杉原一正, 他：多形性腺腫の臨床的統計観察. 口科誌 44: 257-260, 1995.
21) Kusafuka K, Yamaguchi A, et al : Expression of bone morphogenetic proteins in salivary pleomorphic adenomas. Virchows Arch 432: 247-253, 1998.
12) Takeda Y and Yamamoto H : Stromal bone formation in pleomorphic adenoma of minor salivary gland origin. J Nihon Univ Sch Dent 38: 102-104, 1996.
17) Xu H, Shimizu Y, et al : Pleomorphic adenoma of the submandibular salivary glands with marked ossification. J Oral Pathol Med 32: 499-501, 2003.
24) Kusafuka K, Yamaguchi A, et al : Immunohistchemical localization of members of transforming growth factor （TGF）-beta superfamily in normal human salivary glands and pleomorphic adenomas. J Oral Pathol Med 30: 413-420, 2001.
13) Hamakawa H, Takarada M, et al : Bone-forming pleomorphic adenoma of the upper lip: report of a case. J Oral Maxillofac Surg 55: 1471-1475, 1997.
25) Rotter N, Oder J, et al : Isolation and characterization of adult stem cells from human salivary grands. Stem Cells Dev 17: 509-518, 2008.
8) 小村　健 : 唾液腺腫瘍の外科療法. 口腔腫瘍 23: 73-81, 2011.
3) 鈴木美保, 道　泰之, 他：多形性腺腫104例の臨床的検討. 口科誌 55: 34-41, 2006.
20) 森永正二郎：唾液腺の解剖と腫瘍の組織発生. 病理と臨床 7: 545-559, 1989.
2) 山中康嗣, 桐田忠昭, 他：唾液腺腫瘍90例の臨床統計的検討. 口腔腫瘍 11: 1-10, 1999.
6) 川野真太郎, 大部一成, 他：唾液腺腫瘍151例の臨床統計的検討. 日口外誌 52: 393-400, 2006.
14) Chen YK, Lin LM, et al : Palatal pleomorphic adenoma in a child with osteoid formation: report of case. J Dent Child 65: 209-211, 1998.
23) Kusafuka K, Yamaguchi A, et al : Immunohistchemical localization of the bone morphogenetic protein-6 in salivary pleomorphic adenomas. Pathol Int 49: 1023-1027, 1999.
7) Ellis GL and Auclair PL : Atlas of tumor pathology 17. tumors of the salivary glands. 3rd Ed, Armed Forces Institute of Pathology, Washington D.C., 1997, p411-440.
11) Lee KC, Chan JK, et al : Ossifying pleomorphic adenoma of the maxillary antrum. J Laryngol Otol 106: 50-52, 1992.
26) Peiguo C and Lawrence M : Expression of Cytokeratin 5/6 in Epithelial Neoplasms: An Immunohistechemical Study of 509 Cases. Mod Pathol 15: 6-10, 2002.
19) Mandal S, Dhingra K, et al : Extensive bone with marrow formation in pleomorphic adenoma. ANZ J Surg 78: 323-324, 2008.
5) 矢郷　香, 朝波惣一郎, 他：唾液腺腫瘍56例の臨床・病理組織学的検討. 口科誌 56: 356-366, 2007.
9) 長尾孝一：唾液腺腫瘍の鑑別診断（1）. 病理と臨床 4: 1307-1311, 1986.
15) Shigeishi H, Hayashi K, et al : Pleomorphic adenoma of the parotid gland with extensive bone formation. Pathol Int 51: 883-886, 2001.
16) 荒井康仁, 佐久間洋子, 他：著明な骨形成を認めた多形性腺腫の1例. 日口外誌 49: 272-275, 2003.
References_xml – reference: 25) Rotter N, Oder J, et al : Isolation and characterization of adult stem cells from human salivary grands. Stem Cells Dev 17: 509-518, 2008.
– reference: 26) Peiguo C and Lawrence M : Expression of Cytokeratin 5/6 in Epithelial Neoplasms: An Immunohistechemical Study of 509 Cases. Mod Pathol 15: 6-10, 2002.
– reference: 20) 森永正二郎：唾液腺の解剖と腫瘍の組織発生. 病理と臨床 7: 545-559, 1989.
– reference: 21) Kusafuka K, Yamaguchi A, et al : Expression of bone morphogenetic proteins in salivary pleomorphic adenomas. Virchows Arch 432: 247-253, 1998.
– reference: 17) Xu H, Shimizu Y, et al : Pleomorphic adenoma of the submandibular salivary glands with marked ossification. J Oral Pathol Med 32: 499-501, 2003.
– reference: 18) 渡邊武寛, 清水貴子, 他：骨組織形成を伴う多形性腺腫の1症例. 松本歯学 32: 133-137, 2006.
– reference: 3) 鈴木美保, 道　泰之, 他：多形性腺腫104例の臨床的検討. 口科誌 55: 34-41, 2006.
– reference: 5) 矢郷　香, 朝波惣一郎, 他：唾液腺腫瘍56例の臨床・病理組織学的検討. 口科誌 56: 356-366, 2007.
– reference: 15) Shigeishi H, Hayashi K, et al : Pleomorphic adenoma of the parotid gland with extensive bone formation. Pathol Int 51: 883-886, 2001.
– reference: 8) 小村　健 : 唾液腺腫瘍の外科療法. 口腔腫瘍 23: 73-81, 2011.
– reference: 16) 荒井康仁, 佐久間洋子, 他：著明な骨形成を認めた多形性腺腫の1例. 日口外誌 49: 272-275, 2003.
– reference: 13) Hamakawa H, Takarada M, et al : Bone-forming pleomorphic adenoma of the upper lip: report of a case. J Oral Maxillofac Surg 55: 1471-1475, 1997.
– reference: 14) Chen YK, Lin LM, et al : Palatal pleomorphic adenoma in a child with osteoid formation: report of case. J Dent Child 65: 209-211, 1998.
– reference: 1) 内山英樹, 杉原一正, 他：多形性腺腫の臨床的統計観察. 口科誌 44: 257-260, 1995.
– reference: 10) Yates PO and Paget GE : A mixed tumor of salivary gland showing bone formation, with a histochemical study of the tumor mucoids. J Pathol Bacteriol 64: 881-887, 1952.
– reference: 6) 川野真太郎, 大部一成, 他：唾液腺腫瘍151例の臨床統計的検討. 日口外誌 52: 393-400, 2006.
– reference: 9) 長尾孝一：唾液腺腫瘍の鑑別診断（1）. 病理と臨床 4: 1307-1311, 1986.
– reference: 24) Kusafuka K, Yamaguchi A, et al : Immunohistchemical localization of members of transforming growth factor （TGF）-beta superfamily in normal human salivary glands and pleomorphic adenomas. J Oral Pathol Med 30: 413-420, 2001.
– reference: 2) 山中康嗣, 桐田忠昭, 他：唾液腺腫瘍90例の臨床統計的検討. 口腔腫瘍 11: 1-10, 1999.
– reference: 12) Takeda Y and Yamamoto H : Stromal bone formation in pleomorphic adenoma of minor salivary gland origin. J Nihon Univ Sch Dent 38: 102-104, 1996.
– reference: 7) Ellis GL and Auclair PL : Atlas of tumor pathology 17. tumors of the salivary glands. 3rd Ed, Armed Forces Institute of Pathology, Washington D.C., 1997, p411-440.
– reference: 22) Kusafuka K, Yamaguchi A, et al : Expression of bone matrix proteins, Osteonectin and Osteopontin, in salivary pleomorphic adenomas. Pathol Res Pract 195: 733-739, 1999.
– reference: 19) Mandal S, Dhingra K, et al : Extensive bone with marrow formation in pleomorphic adenoma. ANZ J Surg 78: 323-324, 2008.
– reference: 23) Kusafuka K, Yamaguchi A, et al : Immunohistchemical localization of the bone morphogenetic protein-6 in salivary pleomorphic adenomas. Pathol Int 49: 1023-1027, 1999.
– reference: 4) 石川梧郎, 秋吉正豊：口腔病理学II. 改訂版, 永末書店, 京都, 1982, 716-762頁.
– reference: 11) Lee KC, Chan JK, et al : Ossifying pleomorphic adenoma of the maxillary antrum. J Laryngol Otol 106: 50-52, 1992.
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Snippet We report a rare case of pleomorphic adenoma with dystrophic calcification and bone formation in the capsule of the submandibular gland. A 48-year-old man...
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SubjectTerms 唾液腺腫瘍
多形腺腫
異栄養性石灰化
骨形成
Title 被膜に著明な石灰化と骨形成を認めた顎下腺多形腺腫の1例
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