上唇に発生した孤立性線維性腫瘍の1例
In the WHO classification of soft tissue tumors, solitary fibrous tumor (SFT) belongs to fibroblastic/myofibroblastic tumors with intermediate malignancy (rarely metastasizing). Although this tumor occurs mainly in the pleura, extrapleuratic tumors have been reported in ubiquitous sites, including t...
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| Published in | 日本口腔外科学会雑誌 Vol. 56; no. 11; pp. 659 - 663 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 日本口腔外科学会
2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.56.659 |
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| Abstract | In the WHO classification of soft tissue tumors, solitary fibrous tumor (SFT) belongs to fibroblastic/myofibroblastic tumors with intermediate malignancy (rarely metastasizing). Although this tumor occurs mainly in the pleura, extrapleuratic tumors have been reported in ubiquitous sites, including the oral cavity, with a predisposition to the buccal region. We report a rare SFT arising in the upper lip. A 70-year-old man presented with a painless mass. MR images showed a homogeneously enhanced neoplasm. The tumor was resected surgically and exhibited the histopathological features of SFT. It consisted of collagen-forming, CD34-positive fibroblastic spindle cells in a haphazard arrangement, accompanied by a prominent hemangiopericytoma-like branching vascular pattern. Although there was no evidence of local recurrence or metastasis 1 year after sugery, long-term follow-up is mandatory because of the unpredictable behavior of SFT. |
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| AbstractList | In the WHO classification of soft tissue tumors, solitary fibrous tumor (SFT) belongs to fibroblastic/myofibroblastic tumors with intermediate malignancy (rarely metastasizing). Although this tumor occurs mainly in the pleura, extrapleuratic tumors have been reported in ubiquitous sites, including the oral cavity, with a predisposition to the buccal region. We report a rare SFT arising in the upper lip. A 70-year-old man presented with a painless mass. MR images showed a homogeneously enhanced neoplasm. The tumor was resected surgically and exhibited the histopathological features of SFT. It consisted of collagen-forming, CD34-positive fibroblastic spindle cells in a haphazard arrangement, accompanied by a prominent hemangiopericytoma-like branching vascular pattern. Although there was no evidence of local recurrence or metastasis 1 year after sugery, long-term follow-up is mandatory because of the unpredictable behavior of SFT. |
| Author | 今井, 智章 清水, 英孝 藤田, 源太郎 道澤, 雅裕 |
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| Copyright | 2010 社団法人 日本口腔外科学会 |
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| References | 22) Kawahara, K., Hotta, F., et al.: Solitary fibrous tumor arising from the submucosa of the cheek. Aichi- Gakuin Dental Science 16: 37-42 2003. 20) Yamashita, Y., Satoh, Y., et al.: Solitary fibrous tumour of the tongue: a case report with immunohistochemical studies. Int J Oral Maxillofac Surg 31: 681-683 2002. 28) 山本雅大, 池畑正宏, 他：切除11年後に肺転移をきたした口腔原発胸膜外孤立性線維性腫瘍の1例. 診断病理 24: 209-211 2007. 5) Fukasawa, Y., Takada, A., et al.: Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II. Pathol Int 48: 47-52 1998. 2) 久岡正典：孤立性線維性腫瘍とその類縁腫瘍. 病理と臨床 22: 132-139 2004. 12) Imai, T., Michizawa, M., et al.: Bilateral multiple spindle cell lipomas of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106: 264-269 2008. 21) Yamamoto, S., Kawasaki, G., et al.: Solitary fibrous tumour of the buccal mucosa: immunohistochemi-cal and ultrastructural observation. Asian J Oral Maxillofac Surg 15: 199-204 2003. 24) Shimoyama, T., Horie, N., et al.: Solitary fibrous tumor of the palate: a case report and review of the literature. J Oral Maxillofac Surg 62: 895-897 2004. 16) Iwai, S., Nakazawa, M., et al.: Solitary fibrous tumor of the buccal mucosa: report of a case with immunohistochemical studies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88: 461-465 1999. 13) Vallat-Decouvelaere, A.V., Dry, S.M., et al.: Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22: 1501-1511 1998. 19) Harada, T., Matsuda, H., et al.: Solitary fibrous tumours of the lower gingiva: a case report. Int J Oral Maxillofac Surg 31: 448-450 2002. 7) Suster, S. and Fisher, C.: Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. Am J Surg Pathol 21: 195-200 1997. 15) 白水敬昌, 堀田文雄, 他：頬部に発生したSolitary Fibrous Tumorの1例. 口科誌 48: 339-343 1999. 17) 岡部孝一, 宮田 勝, 他：口腔に発生した孤立性線維性腫瘍の1例. 日口外誌 47: 532-535 2001. 4) Alawi, F., Stratton, D., et al.: Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol 25: 900-910 2001. 11) Sakai, H., Kuroda, K., et al.: Coexistence of spindle cell lipoma and ordinary lipoma. J Dermatol 31: 831- 834 2004. 29) Fujii, H., Fujiwara, S., et al.: 頬粘膜の孤立性線維性腫瘍症の1例. Aichi-Gakuin Dental Science 21: 23-27 2008. 3) Fletcher, C.D.M., Unni, K., et al., eds. World Health Organization classification of tumours, pathology & genetics, tumours of soft tissue and bone. 2002, IARC Press: Lyon. 86-90. 14) Kurihara, K., Mizuseki, K., et al.: Solitary fibrous tumor of the oral cavity: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87: 223-226 1999. 10) Gruber, B.L., Kew, R.R., et al.: Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis. J Immunol 158: 2310-2317 1997. 27) Tanio, K., Ryoke, K., et al.: Solitary fibrous tumor of the buccal mucosa: a patient report. Yonago Acta Medica 48: 75-81 2005. 23) Ogawa, I., Sato, S., et al.: Solitary fibrous tumor with malignant potential arising in sublingual gland. Pathol Int 53: 40-45 2003. 30) 冨原 圭, 仲森健治, 他：頬部に発生した孤立性線維性腫瘍の1例. 日口外誌 54: 54-58 2008. 8) Chan, J.K.: Solitary fibrous tumour − everywhere, and a diagnosis in vogue. Histopathology 31: 568-576 1997. 6) 鎌田理恵, 大塚尚治, 他： DICを併発した殿部solitary fibrous tumorの1例. 日形会誌 28: 466-470 2008. 1) Klemperer, P. and Rabin, C.B.: Primary neoplasms of the pleura: a report of five cases. Arch Pathol 11: 385- 412 1931. 18) Hirano, M., Tanuma, J., et al.: Solitary fibrous tumor in the mental region. Pathol Int 51: 905-908 2001. 9) 高木正之：血管周皮腫の位置づけと鑑別診断. 病理と臨床 23: 1303-1308 2005. 25) 立花哲也, 千葉博茂, 他：耳前部に発生した孤立性線維性腫瘍の1例. 日口外誌 50: 239-242 2004. 26) Ide, F., Obara, K., et al.: Ultrastructural spectrum of solitary fibrous tumor: a unique perivascular tumor with alternative lines of differentiation. Virchows Arch 446: 646-652 2005. |
| References_xml | – reference: 15) 白水敬昌, 堀田文雄, 他：頬部に発生したSolitary Fibrous Tumorの1例. 口科誌 48: 339-343 1999. – reference: 20) Yamashita, Y., Satoh, Y., et al.: Solitary fibrous tumour of the tongue: a case report with immunohistochemical studies. Int J Oral Maxillofac Surg 31: 681-683 2002. – reference: 30) 冨原 圭, 仲森健治, 他：頬部に発生した孤立性線維性腫瘍の1例. 日口外誌 54: 54-58 2008. – reference: 13) Vallat-Decouvelaere, A.V., Dry, S.M., et al.: Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22: 1501-1511 1998. – reference: 22) Kawahara, K., Hotta, F., et al.: Solitary fibrous tumor arising from the submucosa of the cheek. Aichi- Gakuin Dental Science 16: 37-42 2003. – reference: 5) Fukasawa, Y., Takada, A., et al.: Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II. Pathol Int 48: 47-52 1998. – reference: 9) 高木正之：血管周皮腫の位置づけと鑑別診断. 病理と臨床 23: 1303-1308 2005. – reference: 18) Hirano, M., Tanuma, J., et al.: Solitary fibrous tumor in the mental region. Pathol Int 51: 905-908 2001. – reference: 21) Yamamoto, S., Kawasaki, G., et al.: Solitary fibrous tumour of the buccal mucosa: immunohistochemi-cal and ultrastructural observation. Asian J Oral Maxillofac Surg 15: 199-204 2003. – reference: 7) Suster, S. and Fisher, C.: Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. Am J Surg Pathol 21: 195-200 1997. – reference: 3) Fletcher, C.D.M., Unni, K., et al., eds. World Health Organization classification of tumours, pathology & genetics, tumours of soft tissue and bone. 2002, IARC Press: Lyon. 86-90. – reference: 4) Alawi, F., Stratton, D., et al.: Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol 25: 900-910 2001. – reference: 6) 鎌田理恵, 大塚尚治, 他： DICを併発した殿部solitary fibrous tumorの1例. 日形会誌 28: 466-470 2008. – reference: 16) Iwai, S., Nakazawa, M., et al.: Solitary fibrous tumor of the buccal mucosa: report of a case with immunohistochemical studies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88: 461-465 1999. – reference: 14) Kurihara, K., Mizuseki, K., et al.: Solitary fibrous tumor of the oral cavity: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87: 223-226 1999. – reference: 10) Gruber, B.L., Kew, R.R., et al.: Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis. J Immunol 158: 2310-2317 1997. – reference: 12) Imai, T., Michizawa, M., et al.: Bilateral multiple spindle cell lipomas of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106: 264-269 2008. – reference: 23) Ogawa, I., Sato, S., et al.: Solitary fibrous tumor with malignant potential arising in sublingual gland. Pathol Int 53: 40-45 2003. – reference: 8) Chan, J.K.: Solitary fibrous tumour − everywhere, and a diagnosis in vogue. Histopathology 31: 568-576 1997. – reference: 29) Fujii, H., Fujiwara, S., et al.: 頬粘膜の孤立性線維性腫瘍症の1例. Aichi-Gakuin Dental Science 21: 23-27 2008. – reference: 28) 山本雅大, 池畑正宏, 他：切除11年後に肺転移をきたした口腔原発胸膜外孤立性線維性腫瘍の1例. 診断病理 24: 209-211 2007. – reference: 2) 久岡正典：孤立性線維性腫瘍とその類縁腫瘍. 病理と臨床 22: 132-139 2004. – reference: 27) Tanio, K., Ryoke, K., et al.: Solitary fibrous tumor of the buccal mucosa: a patient report. Yonago Acta Medica 48: 75-81 2005. – reference: 11) Sakai, H., Kuroda, K., et al.: Coexistence of spindle cell lipoma and ordinary lipoma. J Dermatol 31: 831- 834 2004. – reference: 24) Shimoyama, T., Horie, N., et al.: Solitary fibrous tumor of the palate: a case report and review of the literature. J Oral Maxillofac Surg 62: 895-897 2004. – reference: 25) 立花哲也, 千葉博茂, 他：耳前部に発生した孤立性線維性腫瘍の1例. 日口外誌 50: 239-242 2004. – reference: 1) Klemperer, P. and Rabin, C.B.: Primary neoplasms of the pleura: a report of five cases. Arch Pathol 11: 385- 412 1931. – reference: 26) Ide, F., Obara, K., et al.: Ultrastructural spectrum of solitary fibrous tumor: a unique perivascular tumor with alternative lines of differentiation. Virchows Arch 446: 646-652 2005. – reference: 17) 岡部孝一, 宮田 勝, 他：口腔に発生した孤立性線維性腫瘍の1例. 日口外誌 47: 532-535 2001. – reference: 19) Harada, T., Matsuda, H., et al.: Solitary fibrous tumours of the lower gingiva: a case report. Int J Oral Maxillofac Surg 31: 448-450 2002. |
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| Title | 上唇に発生した孤立性線維性腫瘍の1例 |
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