断続的断眠誘発性衝動性様行動における海馬α2A受容体の関与

• Published in: 日本薬理学会年会要旨集 p. 3-P-286
• Main Authors: 八百板, 富紀枝, 名村, 幸大, 柴田, 楓, 菅原, 彩, 土谷, 昌広, 只野, 武, 丹野, 孝一
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2020
• Subjects: adrenergic alpha receptor; hippocampus
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.93.0_3-P-286

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. In this study, we investigated whether intermittent sleep deprivation (SD) caused changes in impulsive-like behaviors and expression levels of alpha2A-adrenoceptors (alpha2A-R) in the hippocampus (HP) and frontal cortex of mice using an elevated plus maze (EPM) test. Mice were deprived of REM sleep intermittently by using the platform method (20 h/day) for 3 days. The % of time spent in the open arm (TOA) and alpha2A-R expression in HP were significantly increased and decreased, respectively, by SD. The increase in the % of TOA was significantly improved by oxymetazoline (OXY, an alpha2A-R agonist), methylphenidate, and atomoxetine, which are clinically used to treat ADHD symptoms. Moreover, these positive effects of OXY were attenuated by yohimbine a selective alpha2-R antagonist and BRL44408 a selective alpha2A-R antagonist. These results suggest that the increase in the % of TOA induced by SD may serve as a model of the impulsivity-like behavior in ADHD. Furthermore, the SD eliciting impulsive behaviors may be linked to alpha2A-R signaling, and as indicated by a decrease in alpha2A-R, particularly in the mouse HP of mice.