舌扁平上皮癌と悪性リンパ腫の同時性重複がんに対し集学的な治療を行った1例

Squamous cell carcinoma (SCC) is the most common malignancy in the head and neck region, while malignant lymphoma (ML) is relatively rare. According to reporting, synchronous double cancer of squamous cell carcinoma and malignant lymphoma in the head and neck is extremely rare.　A 61-year-old man was...

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Published in日本口腔外科学会雑誌 Vol. 69; no. 1; pp. 15 - 21
Main Authors 小畑, 協一, 伊原木, 聰一郎, 竜門, 省二, 岸本, 晃治, 金本, 栄華, 佐々木, 朗
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本口腔外科学会 20.01.2023
Subjects
同時性重複がん
悪性リンパ腫
扁平上皮癌
濾胞性リンパ腫
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.69.15

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Abstract Squamous cell carcinoma (SCC) is the most common malignancy in the head and neck region, while malignant lymphoma (ML) is relatively rare. According to reporting, synchronous double cancer of squamous cell carcinoma and malignant lymphoma in the head and neck is extremely rare.　A 61-year-old man was referred to our department because of a tongue mass. The mass was elastic-hard and located on the right border of the tongue. Various imaging examinations revealed multiple lymphadenopathies throughout the body. Biopsy resulted in a diagnosis of synchronous double cancer of squamous cell carcinoma of the tongue and follicular lymphoma (FL). During a tumor clinical therapeutic conference, it was decided to prioritize tongue cancer treatment. Following preoperative chemotherapy, we performed a right-sided modified radical neck dissection, tongue cancer resection, and reconstruction using a pectoral major musculocutaneous flap. He was then given chemotherapy for the FL at the Department of Hematology and made good progress.　Since the prognosis for synchronous double cancers is affected to a large degree by the order of treatment, it is very important to collaborate with the relevant specialized departments to provide multidisciplinary treatment.
AbstractList Squamous cell carcinoma (SCC) is the most common malignancy in the head and neck region, while malignant lymphoma (ML) is relatively rare. According to reporting, synchronous double cancer of squamous cell carcinoma and malignant lymphoma in the head and neck is extremely rare.　A 61-year-old man was referred to our department because of a tongue mass. The mass was elastic-hard and located on the right border of the tongue. Various imaging examinations revealed multiple lymphadenopathies throughout the body. Biopsy resulted in a diagnosis of synchronous double cancer of squamous cell carcinoma of the tongue and follicular lymphoma (FL). During a tumor clinical therapeutic conference, it was decided to prioritize tongue cancer treatment. Following preoperative chemotherapy, we performed a right-sided modified radical neck dissection, tongue cancer resection, and reconstruction using a pectoral major musculocutaneous flap. He was then given chemotherapy for the FL at the Department of Hematology and made good progress.　Since the prognosis for synchronous double cancers is affected to a large degree by the order of treatment, it is very important to collaborate with the relevant specialized departments to provide multidisciplinary treatment.
Author 佐々木, 朗
竜門, 省二
金本, 栄華
伊原木, 聰一郎
小畑, 協一
岸本, 晃治
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References 12) Devan J, Janikova A, et al : New concepts in follicular lymphoma biology : From BCL2 to epigenetic regulators and non-coding RNAs. Semin Oncol 45: 291-302, 2018.
28) 佐藤慎太郎， 柿添亜矢， 他：頭頸部扁平上皮癌・悪性リンパ腫同時重複2例．耳鼻臨床 96: 73-78, 2003.
34) Ma TM, Kang H, et al : Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report. Cancers Head Neck 3: 2018.
16) Seymour JF, Marcus R, et al : Association of early disease progression and very poor survival in the GALLIUM study in follicular lymphoma: benefit of obinutuzumab in reducing the rate of early progression. Haematologica 104: 1202-1208, 2019.
10) Yu Y, Shi X, et al : Second malignant neoplasms in lymphomas, secondary lymphomas and lymphomas in metabolic disorders/diseases. Cell Biosci 12: 2022.
3) 天野智子， 薮田良三， 他：上顎癌と頭頸部悪性リンパ腫の重複悪性腫瘍の一例．耳鼻臨床 74: 2151-2155, 1981.
6) 首藤敦史， 竹信俊彦， 他：下顎歯肉扁平上皮癌と頸部原発悪性リンパ腫の同時性重複がんの1例．日口外誌 63: 45-50, 2017.
36) 吉田祥子， 岸本晃治， 他：舌扁平上皮癌における新TNM分類 (UICC：第8版) の実用性．口腔腫瘍 30: 151-157, 2018.
25) Morton LM, Curtis RE, et al : Second malignancy risks after non-Hodgkin’s lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype. J Clin Oncol 28: 4935-4944, 2010.
14) Muto R, Miyoshi H, et al : Epidemiology and secular trends of malignant lymphoma in Japan: Analysis of 9426 cases according to the World Health Organization classification. Cancer Med 7: 5843-5858, 2018.
27) Sacchi S, Marcheselli L, et al : Secondary malignancies after treatment for indolent non-Hodgkin’s lymphoma: a 16-year follow-up study. Haematologica 93: 398-404, 2008.
17) Grigg A, Dyer MJ, et al : Safety and efficacy of obinutuzumab with CHOP or bendamustine in previously untreated follicular lymphoma. Haematologica 102: 765-772, 2017.
23) Gluckman JL, Crissman JD, et al : Multicentric squamous-cell carcinoma of the upper aerodigestive tract: Head Neck Surg 3: 90-96, 1980.
22) 鹿嶋光司， 有馬良治， 他：頭頸部癌患者における重複癌の検討．口科誌 42: 316-323, 1993.
11) Hu L, Luo D, et al : The association between non-Hodgkin lymphoma and organophosphate pesticides exposure: A meta-analysis. Environ Pollut 231: 319-328, 2017.
19) 日本口腔腫瘍学会：6 多発癌 重複癌 ; 口腔癌取り扱い規約．第2版， 金原出版， 東京， 2019, 7 頁
24) Singh NJ, Tripathy N, et al : Simultaneous triple primary head and neck malignancies: A rare case report. Head Neck Pathol 10: 233-236, 2016.
1) Morita Y, Kimoto N, et al : Squamous cell carcinoma and malignant lymphoma as synchronous malignant tumours in the oral cavity. Asian J Oral Maxillofac Surg 21: 64-68, 2009.
20) 水本　結， 齋藤祐毅， 他：口腔癌における重複癌のリスク因子に関する検討．頭頸部外 31: 141-146, 2021.
30) Millwaters M, Khan N, et al : Simultaneous lymphoma and squamous cell carcinoma presenting as a neck lump. Br J Oral Maxillofac Surg 46: 144-145, 2008.
4) 土井理恵子， 小谷　勇， 他：悪性リンパ腫の第二癌としてみられた下顎歯肉癌の2例．口腔腫瘍 26: 113-121, 2014.
13) Zapater E, Bagán JV, et al : Malignant lymphoma of the head and neck. Oral Dis 16: 119-128, 2010.
33) Watanabe N, Inohara H, et al : Synchronous squamous cell carcinoma and malignant lymphoma in the head and neck region. Auris Nasus Larynx 34: 273-276, 2007.
29) Stack BC Jr, Ridley MB, et al : Simultaneous squamous cell carcinoma of the head and neck and reticuloendothelial malignancies. Am J Otolaryngol 17: 178-183, 1996.
15) Freedman A and Jacobsen E : Follicular lymphoma: 2020 update on diagnosis. Am J Hematol 95: 316-327, 2020.
26) 中村和正， 大曲淳一， 他：非ホジキンリンパ腫における重複癌症例の検討．癌の臨 45: 467-470, 1999.
9) Jaffe ES and Wilson WH : Lymphomatoid granulomatosis. In Steven H, Swerdlow SH, et al eds; WHO classification of tumours of haematopoietic and lymphoid tissues, IRAC Press, Lyon, 2017, p121-126.
5) 阿部　厚， 足立守安， 他：悪性リンパ腫と下顎歯肉癌の同時性重複癌の1例．日口診誌 27: 257-261, 2014.
7) 日本血液学会：Ⅱ悪性リンパ腫 / 濾胞性リンパ腫 ; 造血器腫瘍診療ガイドライン 2018 年版補訂版．金原出版， 東京， 2020, 166-189 頁
31) Tezer MS, Tuncel U, et al : Coexistence of laryngeal squamous cell carcinoma and non-Hodgkin’s lymphoma with nasopharyngeal involvement. J Laryngol Otol 120: e2, 2006.
2) 川俣　綾， 水谷美保， 他：口腔領域に初発症状を呈した悪性リンパ腫の臨床的検討－本邦における報告例の考察－．口腔腫瘍 27: 119-125, 2015.
8) 山村佳子， 真野隆充， 他：口腔領域に発生した悪性リンパ腫の臨床的検討．口腔腫瘍 33: 35-40, 2021.
21) 井口広義， 楠木　誠， 他：頭頸部癌症例における重複悪性腫瘍の臨床的検討．癌の臨 49: 1411-1415, 2003.
35) 安松隆治， 内　龍太郎， 他：新TNM分類に基づいた舌扁平上皮癌の臨床検討．頭頸部外 29: 273-278, 2019.
18) 道　泰之， 村嶋真由子， 他：口腔扁平上皮癌患者における重複癌の臨床的検討．口腔腫瘍 24: 1-7, 2012.
32) Joo YH, Jung CK, et al : Synchronous laryngeal squamous cell carcinoma and Hodgkin lymphoma of the head and neck region. Auris Nasus Larynx 36: 501-504, 2009.
References_xml – reference: 22) 鹿嶋光司， 有馬良治， 他：頭頸部癌患者における重複癌の検討．口科誌 42: 316-323, 1993.
– reference: 36) 吉田祥子， 岸本晃治， 他：舌扁平上皮癌における新TNM分類 (UICC：第8版) の実用性．口腔腫瘍 30: 151-157, 2018.
– reference: 21) 井口広義， 楠木　誠， 他：頭頸部癌症例における重複悪性腫瘍の臨床的検討．癌の臨 49: 1411-1415, 2003.
– reference: 12) Devan J, Janikova A, et al : New concepts in follicular lymphoma biology : From BCL2 to epigenetic regulators and non-coding RNAs. Semin Oncol 45: 291-302, 2018.
– reference: 20) 水本　結， 齋藤祐毅， 他：口腔癌における重複癌のリスク因子に関する検討．頭頸部外 31: 141-146, 2021.
– reference: 7) 日本血液学会：Ⅱ悪性リンパ腫 / 濾胞性リンパ腫 ; 造血器腫瘍診療ガイドライン 2018 年版補訂版．金原出版， 東京， 2020, 166-189 頁．
– reference: 23) Gluckman JL, Crissman JD, et al : Multicentric squamous-cell carcinoma of the upper aerodigestive tract: Head Neck Surg 3: 90-96, 1980.
– reference: 14) Muto R, Miyoshi H, et al : Epidemiology and secular trends of malignant lymphoma in Japan: Analysis of 9426 cases according to the World Health Organization classification. Cancer Med 7: 5843-5858, 2018.
– reference: 18) 道　泰之， 村嶋真由子， 他：口腔扁平上皮癌患者における重複癌の臨床的検討．口腔腫瘍 24: 1-7, 2012.
– reference: 26) 中村和正， 大曲淳一， 他：非ホジキンリンパ腫における重複癌症例の検討．癌の臨 45: 467-470, 1999.
– reference: 16) Seymour JF, Marcus R, et al : Association of early disease progression and very poor survival in the GALLIUM study in follicular lymphoma: benefit of obinutuzumab in reducing the rate of early progression. Haematologica 104: 1202-1208, 2019.
– reference: 3) 天野智子， 薮田良三， 他：上顎癌と頭頸部悪性リンパ腫の重複悪性腫瘍の一例．耳鼻臨床 74: 2151-2155, 1981.
– reference: 6) 首藤敦史， 竹信俊彦， 他：下顎歯肉扁平上皮癌と頸部原発悪性リンパ腫の同時性重複がんの1例．日口外誌 63: 45-50, 2017.
– reference: 8) 山村佳子， 真野隆充， 他：口腔領域に発生した悪性リンパ腫の臨床的検討．口腔腫瘍 33: 35-40, 2021.
– reference: 19) 日本口腔腫瘍学会：6 多発癌 重複癌 ; 口腔癌取り扱い規約．第2版， 金原出版， 東京， 2019, 7 頁．
– reference: 30) Millwaters M, Khan N, et al : Simultaneous lymphoma and squamous cell carcinoma presenting as a neck lump. Br J Oral Maxillofac Surg 46: 144-145, 2008.
– reference: 34) Ma TM, Kang H, et al : Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report. Cancers Head Neck 3: 2018.
– reference: 9) Jaffe ES and Wilson WH : Lymphomatoid granulomatosis. In Steven H, Swerdlow SH, et al eds; WHO classification of tumours of haematopoietic and lymphoid tissues, IRAC Press, Lyon, 2017, p121-126.
– reference: 15) Freedman A and Jacobsen E : Follicular lymphoma: 2020 update on diagnosis. Am J Hematol 95: 316-327, 2020.
– reference: 32) Joo YH, Jung CK, et al : Synchronous laryngeal squamous cell carcinoma and Hodgkin lymphoma of the head and neck region. Auris Nasus Larynx 36: 501-504, 2009.
– reference: 1) Morita Y, Kimoto N, et al : Squamous cell carcinoma and malignant lymphoma as synchronous malignant tumours in the oral cavity. Asian J Oral Maxillofac Surg 21: 64-68, 2009.
– reference: 35) 安松隆治， 内　龍太郎， 他：新TNM分類に基づいた舌扁平上皮癌の臨床検討．頭頸部外 29: 273-278, 2019.
– reference: 13) Zapater E, Bagán JV, et al : Malignant lymphoma of the head and neck. Oral Dis 16: 119-128, 2010.
– reference: 25) Morton LM, Curtis RE, et al : Second malignancy risks after non-Hodgkin’s lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype. J Clin Oncol 28: 4935-4944, 2010.
– reference: 2) 川俣　綾， 水谷美保， 他：口腔領域に初発症状を呈した悪性リンパ腫の臨床的検討－本邦における報告例の考察－．口腔腫瘍 27: 119-125, 2015.
– reference: 28) 佐藤慎太郎， 柿添亜矢， 他：頭頸部扁平上皮癌・悪性リンパ腫同時重複2例．耳鼻臨床 96: 73-78, 2003.
– reference: 11) Hu L, Luo D, et al : The association between non-Hodgkin lymphoma and organophosphate pesticides exposure: A meta-analysis. Environ Pollut 231: 319-328, 2017.
– reference: 17) Grigg A, Dyer MJ, et al : Safety and efficacy of obinutuzumab with CHOP or bendamustine in previously untreated follicular lymphoma. Haematologica 102: 765-772, 2017.
– reference: 24) Singh NJ, Tripathy N, et al : Simultaneous triple primary head and neck malignancies: A rare case report. Head Neck Pathol 10: 233-236, 2016.
– reference: 10) Yu Y, Shi X, et al : Second malignant neoplasms in lymphomas, secondary lymphomas and lymphomas in metabolic disorders/diseases. Cell Biosci 12: 2022.
– reference: 31) Tezer MS, Tuncel U, et al : Coexistence of laryngeal squamous cell carcinoma and non-Hodgkin’s lymphoma with nasopharyngeal involvement. J Laryngol Otol 120: e2, 2006.
– reference: 29) Stack BC Jr, Ridley MB, et al : Simultaneous squamous cell carcinoma of the head and neck and reticuloendothelial malignancies. Am J Otolaryngol 17: 178-183, 1996.
– reference: 33) Watanabe N, Inohara H, et al : Synchronous squamous cell carcinoma and malignant lymphoma in the head and neck region. Auris Nasus Larynx 34: 273-276, 2007.
– reference: 4) 土井理恵子， 小谷　勇， 他：悪性リンパ腫の第二癌としてみられた下顎歯肉癌の2例．口腔腫瘍 26: 113-121, 2014.
– reference: 5) 阿部　厚， 足立守安， 他：悪性リンパ腫と下顎歯肉癌の同時性重複癌の1例．日口診誌 27: 257-261, 2014.
– reference: 27) Sacchi S, Marcheselli L, et al : Secondary malignancies after treatment for indolent non-Hodgkin’s lymphoma: a 16-year follow-up study. Haematologica 93: 398-404, 2008.
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Snippet Squamous cell carcinoma (SCC) is the most common malignancy in the head and neck region, while malignant lymphoma (ML) is relatively rare. According to...
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SubjectTerms 同時性重複がん
悪性リンパ腫
扁平上皮癌
濾胞性リンパ腫
Title 舌扁平上皮癌と悪性リンパ腫の同時性重複がんに対し集学的な治療を行った1例
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