自殺者死後脳における5-HT2A受容体およびM1ムスカリン性アセチルコリン受容体を介するG(alpha)q蛋白の機能的活性化

• Published in: 日本薬理学会年会要旨集 p. 2-O-19
• Main Authors: F., Callado Luis, 小田垣, 雄二, A., García-Sevilla Jesús, Javier, Meana J., 木下, 雅一, 太田, 敏男
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2019
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.92.0_2-O-19

Suicide is a major public health concern and often associated with mental disorders, such as depression, bipolar illness, and schizophrenia. Although psychosocial stressors are major risk factors of suicide behavior, abnormalities in neurobiological mechanisms have been supposed to be another risk factor. In the present study, functional coupling of G(alpha)q proteins with 5-HT2A receptor and M1 muscarinic acetylcholine receptor (mAChR) was determined by means of [35S]GTPγS binding/immunoprecipitation assay in postmortem human brain membranes, and the effects of suicide on these measures were evaluated. Postmortem human brains were obtained from 20 patients with bipolar disorder, 20 depression, 20 schizophrenia, and 20 control subjects, and the patients groups included suicide victims in 14, 17, and 10 subjects, respectively. When these 80 subjects were divided into suicide victims (n = 41) and non-suicide (n = 39), there were no significant differences in %Emax, pEC50, and slope factor values for each of the two measures between them. Our results indicate that 5-HT2A receptor- and M1 mAChR-mediated signaling through G(alpha)q proteins is unaltered in suicide victims.