中性子の基礎知識:粒子線治療に伴う中性子の発生

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Published in医学物理 Vol. 42; no. 3; pp. 156 - 163
Main Authors 森, 祐太郎, 松本, 真之介
Format Journal Article
LanguageJapanese
Published 公益社団法人  日本医学物理学会 30.09.2022
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ISSN1345-5354
2186-9634
DOI10.11323/jjmp.42.3_156

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Author 松本, 真之介
森, 祐太郎
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  organization: 筑波大学 医学医療系
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  fullname: 松本, 真之介
  organization: 東京都立大学 健康福祉学部放射線学科
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References 3)水本元治:中性子源概論.中性子利用実験入門講座講義及び実習テキスト.1–11,(独)日本原子力研究開発機構原子力研修センター,2006
6)Amos TM, Doering RR, Galonsky A, et al.: Production of neutrons with protons of 22, 30, and 40 MeV in stopping targets of carbon, aluminum, copper, silver, tantalum, and lead. Nucl. Sci. Eng. 147: 73–82, 2014
12)Lee S, Lee C, Shin EH, et al.: Measurement of neutron ambient dose equivalent in proton radiotherapy with line-scanning and wobbling mode treatment system. Radiat. Prot. Dosim. 177: 382–388, 2017
1)Brenner DJ, Hall EJ: Secondary neutrons in clinical proton radiotherapy: A charged issue. Radiother. Oncol. 86: 165–170, 2008
5)中村尚司:厚い標的からの生成中性子分布(TTY).RADIOISOTOPES 68: 543–552, 2019
7)Fontenot J, Taddei P, Zheng Y, et al.: Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer. Phys. Med. Biol. 53: 1677–1688, 2008
15)Yonai S, Matsufuji N, Kanai T, et al.: Comparison of measured and calculated in-air secondary neutrons in passive carbon-ion radiotherapy. Radiat. Meas. 45: 1369–1373, 2010
18)Ciocca M, Magro G, Mastella E, et al.: Design and commissioning of the non-dedicated scanning proton beamline for ocular treatment at the synchrotron-based CNAO facility. Med. Phys. 46: 1852–1862, 2019
17)Stolarczyk L, Trinkl S, Romero-Exposito M, et al.: Dose distribution of secondary radiation in a water phantom for a proton pencil beam: EURADOS WG9 intercomparison exercise. Phys. Med. Biol. 63: 085017, 2018
4)Iwamoto Y, Taniguchi S, Nakao N, et al.: Measurement of thick target neutron yields at 0° bombarded with 140, 250 and 350 MeV protons. Nucl. Instrum. Methods Phys. Res., Sec. A 593: 298–306, 2008
9)Yonai S, Matsumoto S: Secondary neutron dose in carbon-ion radiotherapy: Investigations in QST–NIRS. J. Radiat. Prot. Res. 46: 39–47, 2021
26)Matsumoto S, Yonai S: Evaluation of neutron ambient dose equivalent in carbon-ion radiotherapy with energy scanning. Radiat. Prot. Dosim. 191: 310–318, 2020
23)Schneider U, Sumila M, Robotka J: Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy. Theor. Biol. Med. Model 8: 27, 2011
25)Zhang R, Howell RM, Taddei PJ, et al.: A comparative study on the risks of radiogenic second cancers and cardiac mortality in a set of pediatric medulloblastoma patients treated with photon or proton craniospinal irradiation. Radiother. Oncol. 113: 84–88, 2014
24)Brodin NP, Munck Af Rosenschöld P, Aznar MC, et al.: Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma. Acta Oncol. 50: 806–816, 2011
2)Hall EJ: Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int. J. Radiat. Oncol. Biol. Phys. 65(1): 1–7, 2006. Doi:10.1016/j.ijrobp.2006.01.027
21)Bjerre HL, Kronborg MB, Nielsen JC, et al.: Risk of cardiac implantable electronic device malfunctioning during pencil beam proton scanning in an in vitro setting. Int. J. Radiat. Oncol. Biol. Phys. 111: 186–195, 2021
20)Hashimoto T, Demizu Y, Numajiri H, et al: Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): A retrospective multi-institutional study. Jpn. J. Radiol. 40: 525–533, 2022
13)Matsumoto S, Yonai S: Evaluation of neutron ambient dose equivalent in intensity-modulated composite particle therapy. Radiat. Prot. Dosim. 193: 90–95, 2021
14)Trinkl S, Mares V, Englbrecht FS, et al.: Systematic out-of-field secondary neutron spectrometry and dosimetry in pencil beam scanning proton therapy. Med. Phys. 44: 1912, 2017
19)日本放射線腫瘍学会,日本循環器学会:植込み型心臓電気デバイス(CIEDs)装着患者に対する放射線治療ガイドライン.1–18, 2019
22)Schneider U, Zwahlen D, Ross D, et al.: Estimation of radiation-induced cancer from three-dimensional dose distributions: Concept of organ equivalent dose. Int. J. Radiat. Oncol. Biol. Phys. 61: 1510–1515, 2005
8)Yonai S, Matsufuji N, Kanai T, et al.: Measurement of neutron ambient dose equivalent in passive carbon-ion and proton radiotherapies. Med. Phys. 35: 4782–4792, 2008
11)Han S-E, Cho G, Lee SB: An assessment of the secondary neutron dose in the passive scattering proton beam facility of the National Cancer Center. Nucl. Eng. Technol. 49: 801–809, 2017
16)Lillhök J, Persson L, Andersen CE, et al.: Radiation protection measurements with the variance-covariance method in the stray radiation fields from photon and proton therapy facilities. Radiat. Prot. Dosim. 180: 338–341, 2018
10)Matsumoto S, Yonai S, Bolch WE: Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy: Organ doses in pediatric brain tumor treatment. Med. Phys. 46: 5824–5832, 2019
References_xml – reference: 19)日本放射線腫瘍学会,日本循環器学会:植込み型心臓電気デバイス(CIEDs)装着患者に対する放射線治療ガイドライン.1–18, 2019
– reference: 26)Matsumoto S, Yonai S: Evaluation of neutron ambient dose equivalent in carbon-ion radiotherapy with energy scanning. Radiat. Prot. Dosim. 191: 310–318, 2020
– reference: 22)Schneider U, Zwahlen D, Ross D, et al.: Estimation of radiation-induced cancer from three-dimensional dose distributions: Concept of organ equivalent dose. Int. J. Radiat. Oncol. Biol. Phys. 61: 1510–1515, 2005
– reference: 16)Lillhök J, Persson L, Andersen CE, et al.: Radiation protection measurements with the variance-covariance method in the stray radiation fields from photon and proton therapy facilities. Radiat. Prot. Dosim. 180: 338–341, 2018
– reference: 8)Yonai S, Matsufuji N, Kanai T, et al.: Measurement of neutron ambient dose equivalent in passive carbon-ion and proton radiotherapies. Med. Phys. 35: 4782–4792, 2008
– reference: 15)Yonai S, Matsufuji N, Kanai T, et al.: Comparison of measured and calculated in-air secondary neutrons in passive carbon-ion radiotherapy. Radiat. Meas. 45: 1369–1373, 2010
– reference: 4)Iwamoto Y, Taniguchi S, Nakao N, et al.: Measurement of thick target neutron yields at 0° bombarded with 140, 250 and 350 MeV protons. Nucl. Instrum. Methods Phys. Res., Sec. A 593: 298–306, 2008
– reference: 3)水本元治:中性子源概論.中性子利用実験入門講座講義及び実習テキスト.1–11,(独)日本原子力研究開発機構原子力研修センター,2006
– reference: 6)Amos TM, Doering RR, Galonsky A, et al.: Production of neutrons with protons of 22, 30, and 40 MeV in stopping targets of carbon, aluminum, copper, silver, tantalum, and lead. Nucl. Sci. Eng. 147: 73–82, 2014
– reference: 7)Fontenot J, Taddei P, Zheng Y, et al.: Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer. Phys. Med. Biol. 53: 1677–1688, 2008
– reference: 24)Brodin NP, Munck Af Rosenschöld P, Aznar MC, et al.: Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma. Acta Oncol. 50: 806–816, 2011
– reference: 9)Yonai S, Matsumoto S: Secondary neutron dose in carbon-ion radiotherapy: Investigations in QST–NIRS. J. Radiat. Prot. Res. 46: 39–47, 2021
– reference: 17)Stolarczyk L, Trinkl S, Romero-Exposito M, et al.: Dose distribution of secondary radiation in a water phantom for a proton pencil beam: EURADOS WG9 intercomparison exercise. Phys. Med. Biol. 63: 085017, 2018
– reference: 11)Han S-E, Cho G, Lee SB: An assessment of the secondary neutron dose in the passive scattering proton beam facility of the National Cancer Center. Nucl. Eng. Technol. 49: 801–809, 2017
– reference: 12)Lee S, Lee C, Shin EH, et al.: Measurement of neutron ambient dose equivalent in proton radiotherapy with line-scanning and wobbling mode treatment system. Radiat. Prot. Dosim. 177: 382–388, 2017
– reference: 20)Hashimoto T, Demizu Y, Numajiri H, et al: Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): A retrospective multi-institutional study. Jpn. J. Radiol. 40: 525–533, 2022
– reference: 25)Zhang R, Howell RM, Taddei PJ, et al.: A comparative study on the risks of radiogenic second cancers and cardiac mortality in a set of pediatric medulloblastoma patients treated with photon or proton craniospinal irradiation. Radiother. Oncol. 113: 84–88, 2014
– reference: 1)Brenner DJ, Hall EJ: Secondary neutrons in clinical proton radiotherapy: A charged issue. Radiother. Oncol. 86: 165–170, 2008
– reference: 21)Bjerre HL, Kronborg MB, Nielsen JC, et al.: Risk of cardiac implantable electronic device malfunctioning during pencil beam proton scanning in an in vitro setting. Int. J. Radiat. Oncol. Biol. Phys. 111: 186–195, 2021
– reference: 2)Hall EJ: Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int. J. Radiat. Oncol. Biol. Phys. 65(1): 1–7, 2006. Doi:10.1016/j.ijrobp.2006.01.027
– reference: 18)Ciocca M, Magro G, Mastella E, et al.: Design and commissioning of the non-dedicated scanning proton beamline for ocular treatment at the synchrotron-based CNAO facility. Med. Phys. 46: 1852–1862, 2019
– reference: 14)Trinkl S, Mares V, Englbrecht FS, et al.: Systematic out-of-field secondary neutron spectrometry and dosimetry in pencil beam scanning proton therapy. Med. Phys. 44: 1912, 2017
– reference: 5)中村尚司:厚い標的からの生成中性子分布(TTY).RADIOISOTOPES 68: 543–552, 2019
– reference: 13)Matsumoto S, Yonai S: Evaluation of neutron ambient dose equivalent in intensity-modulated composite particle therapy. Radiat. Prot. Dosim. 193: 90–95, 2021
– reference: 23)Schneider U, Sumila M, Robotka J: Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy. Theor. Biol. Med. Model 8: 27, 2011
– reference: 10)Matsumoto S, Yonai S, Bolch WE: Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy: Organ doses in pediatric brain tumor treatment. Med. Phys. 46: 5824–5832, 2019
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SubjectTerms particle therapy
radiation measurement
radiation protection
secondary neutrons
Title 中性子の基礎知識:粒子線治療に伴う中性子の発生
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