BF3·OEt2-AgSCF3 Mediated Trifluoromethylthiolation/Cascade Cyclization of Propynols: Synthesis of 4-((Trifluoromethyl)thio)-2H-chromene and 4-((Trifluoromethyl)thio)-1,2-dihydroquinoline Derivatives

• Published in: Organic letters Vol. 18; no. 7; pp. 1514 - 1517
• Main Authors: Qiu, Yi-Feng, Song, Xian-Rong, Li, Ming, Zhu, Xin-Yu, Wang, An-Qi, Yang, Fang, Han, Ya-Ping, Zhang, Heng-Rui, Jin, Dong-Po, Li, Ying-Xiu, Liang, Yong-Min
• Format: Journal Article
• Language: English
• Published: United States 01.04.2016
• Subjects: chemical structure; cyclization reactions; Lewis bases; organic compounds

A BF3·OEt2-AgSCF3 mediated direct trifluoromethylthiolation/cascade cyclization of propynols involving the SCF3 anion nucleophilic pathway is developed. This protocol also provides an opportunity to construct valuable trifluoromethylthio-substituted 2H-chromene and 1,2-dihydroquinoline systems with...