Long QT syndrome followed by torasades de pointes due to fluconazole in remission induction chemotherapy for acute myelogenous leukemia

• Published in: Japanese Journal of Chemotherapy Vol. 53; no. 7; pp. 412 - 416
• Main Authors: Fujimoto, Yoshinori, Umeda, Masanori, Ishihara, Susumu, Nagase, Daisuke, Arai, Chiaki, Kuraishi, Yasunobu, Sugasawa, Yasuyuki, Kato, Motohiro, Natori, Kazuhiko, Izumi, Haruka, Okuda, Shinya
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 2005; 公益社団法人 日本化学療法学会
• Subjects: acute myelogenous leukemia; fluconazole; QT-prolongation; torasades de pointes
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.53.412

A 48-year-old man diagnosed with acute myeloid leukemia in November 1999 and undergoing bone marrow suppression after remission induction chemotherapy suffered fungal pneumonia treated with anti fungal fluconazole (FLCZ). On day 14 of the anti fungal treatment, he suffering from torsades de points, evidenced by a typical ECG pattern sign curve, was compatible with torasades de points. He felt palpitations and unclear conciousness and we found prolonged QT time on ECG and low serum Ca, grtimenormalized when was FLCZ discontinued and was serum Ca was corrected. This very rare disorder is potentially fatal, and long QT time syndrome should be considered in pastients being treated with FLCZ for fungal infection.