大腸ポリープ患者に対する乳酸菌生成エキス (大豆乳酸菌発酵抽出液) の効果 : 二重盲験比較試験によるパイロット試験
大腸がんは世界的に発症例が増え, その予防と治療に多大な努力がなされている。その予防対策として重視されているのが大腸ポリープ対策であり, 次世代型の予防対策として大腸ポリープの内視鏡による摘出から, 大腸ポリープを発症させない予防, あるいは外科的侵襲のないポリープ対策が期待される。その中で天然素材由来の成分や食事は, がんの予防・リスク低減に向けて広く研究が進められている。これまでに, 乳酸菌生成エキス (大豆乳酸菌発酵エキス, LDS) の経口摂取は, 大腸がん発生モデルマウスにおいて, 初期大腸腺腫および微小腺腫の発症率を著しく低下させることが明らかとなっている。本研究では, 大腸ポリー...
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| Published in | 日本食生活学会誌 Vol. 25; no. 1; pp. 20 - 25 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本食生活学会
2014
|
| Online Access | Get full text |
| ISSN | 1346-9770 1881-2368 |
| DOI | 10.2740/jisdh.25.20 |
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| Abstract | 大腸がんは世界的に発症例が増え, その予防と治療に多大な努力がなされている。その予防対策として重視されているのが大腸ポリープ対策であり, 次世代型の予防対策として大腸ポリープの内視鏡による摘出から, 大腸ポリープを発症させない予防, あるいは外科的侵襲のないポリープ対策が期待される。その中で天然素材由来の成分や食事は, がんの予防・リスク低減に向けて広く研究が進められている。これまでに, 乳酸菌生成エキス (大豆乳酸菌発酵エキス, LDS) の経口摂取は, 大腸がん発生モデルマウスにおいて, 初期大腸腺腫および微小腺腫の発症率を著しく低下させることが明らかとなっている。本研究では, 大腸ポリープ患者に対するLDSの経口摂取による治癒効果を二重盲験比較試験により検証した。その結果, 被験成分摂取群 (LDS 10mL/日摂取, 6か月間) において, ポリープの消失もしくは縮小が8症例中5症例で確認された。なお, 被験成分を含まないプラセボ摂取群では, すべての症例において変化は認められなかった。これらの結果は, LDSの経口摂取は, 副作用に大腸ポリープの治癒あるいは予防に有効であることを示すものである。 |
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| AbstractList | 大腸がんは世界的に発症例が増え, その予防と治療に多大な努力がなされている。その予防対策として重視されているのが大腸ポリープ対策であり, 次世代型の予防対策として大腸ポリープの内視鏡による摘出から, 大腸ポリープを発症させない予防, あるいは外科的侵襲のないポリープ対策が期待される。その中で天然素材由来の成分や食事は, がんの予防・リスク低減に向けて広く研究が進められている。これまでに, 乳酸菌生成エキス (大豆乳酸菌発酵エキス, LDS) の経口摂取は, 大腸がん発生モデルマウスにおいて, 初期大腸腺腫および微小腺腫の発症率を著しく低下させることが明らかとなっている。本研究では, 大腸ポリープ患者に対するLDSの経口摂取による治癒効果を二重盲験比較試験により検証した。その結果, 被験成分摂取群 (LDS 10mL/日摂取, 6か月間) において, ポリープの消失もしくは縮小が8症例中5症例で確認された。なお, 被験成分を含まないプラセボ摂取群では, すべての症例において変化は認められなかった。これらの結果は, LDSの経口摂取は, 副作用に大腸ポリープの治癒あるいは予防に有効であることを示すものである。 |
| Author | 貴家, 康尋 福井, 勝 丸山, 徹 深田, 光敬 藤野, 武彦 若菜, 智香子 斉藤, 和之 小田代, 敬太 |
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| References | 21) Iliev D I, Kitazawa H, Shimosato T, Katoh S, Morita H, He F, Hosoda M, Saito T: Strong immunostimulation in murine immune cells byLactobacillus rhamnosusGG DNA containing noveloligodeoxynucleotide pattern, Cell Microbiol, 7, 403-414 (2005 12) Heuvelin E, Lebreton C, Grangette C, Pot B. Cerf-Bensussan N, Heyman M: Mechanisms involved in alleviation of intestinal inflammation by Bifidobacteruim breve soluble factors, PLoS ONE, 4, e5184 (2009 13) Fukui M, Fujino T, Tsutsui K, Maruyama T, Yoshimura H, Shinohara T, Fukui M, Nada O: The tumor-preventing effect of a mixture of several lactic acid bacteria on 1,2-dimethylhydrazine-induced colon carcinogenesis in mice, Oncol Rep, 8, 1073-1078 (2001 22) Dubé, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D: The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. preventive services task force, Ann Intern Med, 146, 365-375 (2007 3) Kozu T, Iinuma G, Ohashi Y, Saito Y, Akasu T, Saito D, Alexander DB, Ligo M, Kakizoe T, Tsuda H: Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial, Cancer Prev Res, 2, 975-983 (2009 4) Wollowski I, Rechekemmer G, Pool-Zobel BL: Protective role of probiotics and prebiotics in colon cancer, Am J Clin Nutr, 73 (suppl), 451S-455S (2001 10) Ménard S, Candalh C, Bambou JC, Terpend K, Cerf-Bensussan N, Hyman M : Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport, Gut, 53, 821-828 (2004 23) Rostom A, Dubé, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D: Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the US preventive services task force, Ann Intern Med, 146, 376-389 (2007 6) Parvez S, Malik KA, Ah Kang S, Kim H-Y: Probiotics and their fermented food products are beneficial for health, J Apple Microbiol, 100, 1171-1185 (2006 7) Damaskos D, Kolios G: Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope', Br J Clin Pharmacol, 65, 453-467 (2008 2) Liong M-T: Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in-vivo evidence, Int J Mol Sci, 9, 854-863 (2008 1) Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM : Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008, Int J Cancer, 127, 2893-2917 (2010 19) Matsuguchi T, Takagi A, Matsuzaki T, Nagaoka M, Ishikawa K, Yokokura T, Yoshikai Y: Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through toll-like receptor 2, Clin Diagn Lab Immunol, 10, 259-266 (2003 17) Foligne B, Zoumpopoulou G, Dewulf J, Younes AB, Chareyre F, Sirard J-C, Pot B, Grangette C: A key role of dendritic cells in probiotic functionality, PLoS ONE, 32, e313 (2007 20) Sparwasser T, Koch E S, Vabulas R M, Heeg K, Lipford G B, Ellwart J W, Wagne R H: Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells, Eur J Immunol, 28, 2045-2054 (1998 15) Nagao F, Nakayama M, Muto T, Okumura K: Effects of fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects, Biocsi Biotechnol Biochem, 64, 2706-2708 (2000 18) PeañA., Versalovic J: Lactobacillus rhamnosus GG decreases TNF-a production in lipopolysaccharide-activated murine macrophages by a contact-independent mechanism, Cell Microbiol, 5, 277-285 (2003 14) Takahashi S, Kawamura T, Kanda Y, Taniguchi T, Nishizawa T, Iiai T, Hatakeyama K, Abo T: Activation of CD1d-independent NK1. 1+ T cells in the large intestine by Lactobacilli, Immunol Lett, 102, 74-78 (2006 9) Chenoll E, Casinos B, Bataller E, Astals P, Echevarra J, Iglesias JR, Balbarie P, Ramón D, Genovs S: Novel probiotic bifidobacterium bifidum CECT7366 strain active against the pathogenic bacterium Helicobacter pylori, Apple Environ Microbiol, 77, 1335-1343 (2011 11) Zeuthen LH, Christensen HR, Frøkiær H: Lactic acid bacteria inducing a weak interleukin-12 and tumor necrosis factor alpha response in human dendritic cells inhibit strongly stimulating lactic acid bacteria but act synergistically with gram-negative bacteria, Clin Vaccine Immunol, 13, 365-375 (2006 24) Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D, Tappenden P: Chemoprevention of colorectal cancer: systematic review and economic evaluation, Health Technol Assess, 14, 1-206 (2010 8) Lee DK, Jang S, Baek EH, Kim MJ, Lee KS, Shin HS, Chung MJ, Kim JE, Lee KO, Ha NJ: Lactic acid bacteria affect serum cholesterol levels, harmful fecal enzyme activity, and fecal water content, Lipids Health Dis, 8, 21 (2009 5) Yamano T, Iino H, Takada M, Blum S, Rochat F, Fukushima Y: Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsonii La1, Br J Nutr, 95, 303-312 (2006 16) Galdeano CM, Perdigón G: The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity, Clin Vaccine Immunol, 13, 219-226 (2006 |
| References_xml | – reference: 23) Rostom A, Dubé, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D: Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the US preventive services task force, Ann Intern Med, 146, 376-389 (2007) – reference: 14) Takahashi S, Kawamura T, Kanda Y, Taniguchi T, Nishizawa T, Iiai T, Hatakeyama K, Abo T: Activation of CD1d-independent NK1. 1+ T cells in the large intestine by Lactobacilli, Immunol Lett, 102, 74-78 (2006) – reference: 22) Dubé, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D: The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. preventive services task force, Ann Intern Med, 146, 365-375 (2007) – reference: 4) Wollowski I, Rechekemmer G, Pool-Zobel BL: Protective role of probiotics and prebiotics in colon cancer, Am J Clin Nutr, 73 (suppl), 451S-455S (2001) – reference: 12) Heuvelin E, Lebreton C, Grangette C, Pot B. Cerf-Bensussan N, Heyman M: Mechanisms involved in alleviation of intestinal inflammation by Bifidobacteruim breve soluble factors, PLoS ONE, 4, e5184 (2009) – reference: 17) Foligne B, Zoumpopoulou G, Dewulf J, Younes AB, Chareyre F, Sirard J-C, Pot B, Grangette C: A key role of dendritic cells in probiotic functionality, PLoS ONE, 32, e313 (2007) – reference: 19) Matsuguchi T, Takagi A, Matsuzaki T, Nagaoka M, Ishikawa K, Yokokura T, Yoshikai Y: Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through toll-like receptor 2, Clin Diagn Lab Immunol, 10, 259-266 (2003) – reference: 20) Sparwasser T, Koch E S, Vabulas R M, Heeg K, Lipford G B, Ellwart J W, Wagne R H: Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells, Eur J Immunol, 28, 2045-2054 (1998) – reference: 6) Parvez S, Malik KA, Ah Kang S, Kim H-Y: Probiotics and their fermented food products are beneficial for health, J Apple Microbiol, 100, 1171-1185 (2006) – reference: 10) Ménard S, Candalh C, Bambou JC, Terpend K, Cerf-Bensussan N, Hyman M : Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport, Gut, 53, 821-828 (2004) – reference: 1) Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM : Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008, Int J Cancer, 127, 2893-2917 (2010) – reference: 8) Lee DK, Jang S, Baek EH, Kim MJ, Lee KS, Shin HS, Chung MJ, Kim JE, Lee KO, Ha NJ: Lactic acid bacteria affect serum cholesterol levels, harmful fecal enzyme activity, and fecal water content, Lipids Health Dis, 8, 21 (2009) – reference: 11) Zeuthen LH, Christensen HR, Frøkiær H: Lactic acid bacteria inducing a weak interleukin-12 and tumor necrosis factor alpha response in human dendritic cells inhibit strongly stimulating lactic acid bacteria but act synergistically with gram-negative bacteria, Clin Vaccine Immunol, 13, 365-375 (2006) – reference: 16) Galdeano CM, Perdigón G: The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity, Clin Vaccine Immunol, 13, 219-226 (2006) – reference: 7) Damaskos D, Kolios G: Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope', Br J Clin Pharmacol, 65, 453-467 (2008) – reference: 5) Yamano T, Iino H, Takada M, Blum S, Rochat F, Fukushima Y: Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsonii La1, Br J Nutr, 95, 303-312 (2006) – reference: 18) PeañA., Versalovic J: Lactobacillus rhamnosus GG decreases TNF-a production in lipopolysaccharide-activated murine macrophages by a contact-independent mechanism, Cell Microbiol, 5, 277-285 (2003) – reference: 21) Iliev D I, Kitazawa H, Shimosato T, Katoh S, Morita H, He F, Hosoda M, Saito T: Strong immunostimulation in murine immune cells byLactobacillus rhamnosusGG DNA containing noveloligodeoxynucleotide pattern, Cell Microbiol, 7, 403-414 (2005) – reference: 24) Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D, Tappenden P: Chemoprevention of colorectal cancer: systematic review and economic evaluation, Health Technol Assess, 14, 1-206 (2010) – reference: 2) Liong M-T: Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in-vivo evidence, Int J Mol Sci, 9, 854-863 (2008) – reference: 9) Chenoll E, Casinos B, Bataller E, Astals P, Echevarra J, Iglesias JR, Balbarie P, Ramón D, Genovs S: Novel probiotic bifidobacterium bifidum CECT7366 strain active against the pathogenic bacterium Helicobacter pylori, Apple Environ Microbiol, 77, 1335-1343 (2011) – reference: 13) Fukui M, Fujino T, Tsutsui K, Maruyama T, Yoshimura H, Shinohara T, Fukui M, Nada O: The tumor-preventing effect of a mixture of several lactic acid bacteria on 1,2-dimethylhydrazine-induced colon carcinogenesis in mice, Oncol Rep, 8, 1073-1078 (2001) – reference: 15) Nagao F, Nakayama M, Muto T, Okumura K: Effects of fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects, Biocsi Biotechnol Biochem, 64, 2706-2708 (2000) – reference: 3) Kozu T, Iinuma G, Ohashi Y, Saito Y, Akasu T, Saito D, Alexander DB, Ligo M, Kakizoe T, Tsuda H: Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial, Cancer Prev Res, 2, 975-983 (2009) |
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| Snippet | 大腸がんは世界的に発症例が増え, その予防と治療に多大な努力がなされている。その予防対策として重視されているのが大腸ポリープ対策であり, 次世代型の予防対策として大腸ポリープの内視鏡による摘出から, 大腸ポリープを発症させない予防,... |
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| Title | 大腸ポリープ患者に対する乳酸菌生成エキス (大豆乳酸菌発酵抽出液) の効果 : 二重盲験比較試験によるパイロット試験 |
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