My Experience in Mercury Toxicology: Behavioral Teratology Study of the Effects of Prenatal Exposure to Environmental Pollutants
I would like to express sincere thanks to all the people involved in awarding the 2005 Congress Award. It is a great honor to be given the prize. I have been interested in mercury toxicology since I was a graduate student and mercury toxicology has been my main subject of focus for 30 years. I am pr...
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| Published in | Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) Vol. 62; no. 3; pp. 881 - 887 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
The Japanese Society for Hygiene
01.05.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5082 1882-6482 |
| DOI | 10.1265/jjh.62.881 |
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| Abstract | I would like to express sincere thanks to all the people involved in awarding the 2005 Congress Award. It is a great honor to be given the prize. I have been interested in mercury toxicology since I was a graduate student and mercury toxicology has been my main subject of focus for 30 years. I am proud to continue the research in this field. In this presentation I would like to summarize some of my research works and to talk anecdotes related to the research works. Soon after I became involved in this research field, I came across “behavioral teratology”, which is a novel field of study whose focus is understanding the postnatal consequences of exposure to harmful agents in utero. Spyker and her colleagues clearly showed postnatal behavioral deviations in mouse offspring exposed to a low dose of methylmercury prenatally. In various animal experiments, I elucidated the subtle consequences that appear postnatally. I found that these consequences are modified by many factors such as selenium status, PCBs, and heat, because the degree of exposure to produce these consequences can be extremely small. These experiments simulate actual human life and the results will be useful to assess the risk of methylmercury exposure through fish consumption in the human population, since fish eating populations are exposed to these factors at a low dose. Recently, cohort studies elucidating the possible effects of prenatal exposure to environmental pollutants in the postnatal period have been established and ongoing. When a conclusion is drawn, it is expected to serve as basic information that is useful for the risk assessment of methylmercury and other environmental pollutants. This will give great gratification to scientists in environmental health and preventive medicine. |
|---|---|
| AbstractList | I would like to express sincere thanks to all the people involved in awarding the 2005 Congress Award. It is a great honor to be given the prize. I have been interested in mercury toxicology since I was a graduate student and mercury toxicology has been my main subject of focus for 30 years. I am proud to continue the research in this field. In this presentation I would like to summarize some of my research works and to talk anecdotes related to the research works. Soon after I became involved in this research field, I came across "behavioral teratology", which is a novel field of study whose focus is understanding the postnatal consequences of exposure to harmful agents in utero. Spyker and her colleagues clearly showed postnatal behavioral deviations in mouse offspring exposed to a low dose of methylmercury prenatally. In various animal experiments, I elucidated the subtle consequences that appear postnatally. I found that these consequences are modified by many factors such as selenium status, PCBs, and heat, because the degree of exposure to produce these consequences can be extremely small. These experiments simulate actual human life and the results will be useful to assess the risk of methylmercury exposure through fish consumption in the human population, since fish eating populations are exposed to these factors at a low dose. Recently, cohort studies elucidating the possible effects of prenatal exposure to environmental pollutants in the postnatal period have been established and ongoing. When a conclusion is drawn, it is expected to serve as basic information that is useful for the risk assessment of methylmercury and other environmental pollutants. This will give great gratification to scientists in environmental health and preventive medicine.I would like to express sincere thanks to all the people involved in awarding the 2005 Congress Award. It is a great honor to be given the prize. I have been interested in mercury toxicology since I was a graduate student and mercury toxicology has been my main subject of focus for 30 years. I am proud to continue the research in this field. In this presentation I would like to summarize some of my research works and to talk anecdotes related to the research works. Soon after I became involved in this research field, I came across "behavioral teratology", which is a novel field of study whose focus is understanding the postnatal consequences of exposure to harmful agents in utero. Spyker and her colleagues clearly showed postnatal behavioral deviations in mouse offspring exposed to a low dose of methylmercury prenatally. In various animal experiments, I elucidated the subtle consequences that appear postnatally. I found that these consequences are modified by many factors such as selenium status, PCBs, and heat, because the degree of exposure to produce these consequences can be extremely small. These experiments simulate actual human life and the results will be useful to assess the risk of methylmercury exposure through fish consumption in the human population, since fish eating populations are exposed to these factors at a low dose. Recently, cohort studies elucidating the possible effects of prenatal exposure to environmental pollutants in the postnatal period have been established and ongoing. When a conclusion is drawn, it is expected to serve as basic information that is useful for the risk assessment of methylmercury and other environmental pollutants. This will give great gratification to scientists in environmental health and preventive medicine. I would like to express sincere thanks to all the people involved in awarding the 2005 Congress Award. It is a great honor to be given the prize. I have been interested in mercury toxicology since I was a graduate student and mercury toxicology has been my main subject of focus for 30 years. I am proud to continue the research in this field. In this presentation I would like to summarize some of my research works and to talk anecdotes related to the research works. Soon after I became involved in this research field, I came across "behavioral teratology", which is a novel field of study whose focus is understanding the postnatal consequences of exposure to harmful agents in utero. Spyker and her colleagues clearly showed postnatal behavioral deviations in mouse offspring exposed to a low dose of methylmercury prenatally. In various animal experiments, I elucidated the subtle consequences that appear postnatally. I found that these consequences are modified by many factors such as selenium status, PCBs, and heat, because the degree of exposure to produce these consequences can be extremely small. These experiments simulate actual human life and the results will be useful to assess the risk of methylmercury exposure through fish consumption in the human population, since fish eating populations are exposed to these factors at a low dose. Recently, cohort studies elucidating the possible effects of prenatal exposure to environmental pollutants in the postnatal period have been established and ongoing. When a conclusion is drawn, it is expected to serve as basic information that is useful for the risk assessment of methylmercury and other environmental pollutants. This will give great gratification to scientists in environmental health and preventive medicine. |
| Author | SATOH, Hiroshi |
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| References | (27) Nakai K, Satoh H. Developmental neurotoxicity following prenatal exposures to methylmercury and PCBs in humans from epidemiological studies. Tohoku J Exp Med. 2002 ; 196 : 89-98. (36) Yoshida M, Satoh H, Kojima S, Yamamura Y. Metallothionein concentrations and organ retention of mercury in the liver and kidney of the neonatal guinea pig after exposure to mercury vapor. Tohoku J Exp Med. 1991 ; 164 : 13-22. (37) Yoshida M, Satoh H, Kishimoto T, Yamamura Y. Exposure to mercury via breast milk in suckling offspring of maternal guinea pigs exposed to mercury vapor after parturition. J Toxicol Environ Health. 1992 ; 35 : 135-139. (1) 佐藤 洋. 水銀. 佐藤 洋編著. Toxicology Today中毒学から生体防御の科学へ. 京都 : 金芳堂, 1994 : 71-78. (8) Nobunaga T, Satoh H, Suzuki T. Effects of sodium selenite on methylmercury embryotoxicity and tertogenicity. Toxicol Appl Pharmacol. 1979 ; 47 : 79-88. (13) Satoh H, Shimai S, Yasuda N. Mercury metabolism and development of mice offspring perinatally exposed to methylmercury and selenite. Nutr Res. 1985 ; Supplement I : 580-586. (44) Satoh H. Occupational and environmental toxicology of mercury and its compounds. Ind Health. 2000 ; 38 : 153-164. (19) Sugawara N, Nakai K, Nakamura T, Ohba T, Suzuki K, Kameo S, Satoh C, Satoh H. Developmental and neurobehavioral effects of perinatal exposure to polychlorinated biphenyls in mice. Arch Toxicol. 2006 ; 80 : 286-292. (4) 食品安全委員会. 魚介類等に含まれるメチル水銀について. http://www.fsc.go.jp/hyouka/iken.html#04/hy-hyoukamethylmercury.pdf (24) Davidson PW, Kost J, Myers GJ, Cox C, Clarkson TW, Shamlaye CF. Methylmercury and neurodevelopment: reanalysis of the Seychelles Child Development Study outcomes at 66 months of age. JAMA. 2001 ; 285 : 1291-1293. (40) Yoshida M, Watanabe C, Satoh H, Kishimoto T, Yamamura Y. Milk transfer and tissue uptake of mercury in suckling offspring after exposure of lactating maternal guinea pigs to inorganic or methylmercury. Arch Toxicol. 1994 ; 68 : 174-178. (9) Werboff J, Havlena J. Postnatal behavioral effects of tranquilizers administered to the gravid rat. Exp Neurol. 1962 ; 6 : 263-269. (2) Broad WJ. Sir Isaac Newton: mad as a hatter. Science. 1981 ; 213 : 1341-2, 1344. (35) Yoshida M, Satoh H, Kojima S, Yamamura Y. Retention and distribution of mercury in organs of neonatal guinea pigs after in utero exposure to mercury vapor. Journal of Trace Elements in Experimental Medicine. 1990 ; 3 : 219-226. (39) Kishi R, Doi R, Fukuchi Y, Satoh H, Satoh T, Ono A, Moriwaka F, Tashiro K, Takahata N, Sasatani H, Shirakashi H, Kamada T, Nakagawa K. Residual neurobehavioural effects associated with chronic exposure to mercury vapour. Occup Environ Med. 1994 ; 51 : 35-41. (12) Satoh H, Yasuda N, Shimai S. Development of reflexes in neonatal mice perinatally exposed to methylmercury and selenite. Toxicol Lett. 1985 ; 25 : 199-203. (31) Satoh H, Suzuki T, Nobunaga T, Naganuma A, Imura N. Effects of sodium selenite on distribution and placental transfer of mercuric mercury in mice of late gestational period. J Pharmacobio-dyn. 1981 ; 4 : 191-196. (32) Yoshida M, Yamamura Y, Satoh H. Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation. Arch Toxicol. 1986 ; 58 : 225-228. (16) Yin K, Watanabe C, Inaba H, Satoh H. Growth and behavioral changes in mice prenatally exposed to methylmercury and heat. Neurotoxicol Teratol. 1997 ; 19 : 1-7. (3) 佐藤 洋, 鈴木継美. 無機水銀. 祖父江逸朗, 鈴木継美, 村井由之, 池田正之, 兼高達貳, 藤沢 洌編. 産業内科学 神経・筋／消化器・代謝系. 東京 : 医歯薬出版株式会社, 1989 : 64-72. (15) Shimai S, Satoh H. Behavioral teratogenesis of heavy metals: Problems in experimental researches. Congenital Anomaly. 1985 ; 25 : 367-376. (20) Sugawara N, Nakai K, Kameo S, Ohba T, Shimada M, Satoh H. Lesson from an animal experiment of combined exposures to methylmercury and PCBs on neurobehavioral influences in mice. Abstract Book of NIMD Forum 2006, 5. (42) Yamamoto R, Satoh H, Suzuki T, Naganuma A, Imura N. The applicable condition of Magos' method for mercury measurement under coexistence of selenium. Anal Biochem. 1980 ; 101 : 254-259. (5) Ganther HE, Goudie C, Sunde ML, Kopecky MJ, Wagner P. Selenium: relation to decreased toxicity of methylmercury added to diets containing tuna. Science. 1972 ; 175 : 1122-1124. (17) Watanabe C, Yin K, Kasanuma Y, Satoh H. In utero exposure to methylmercury and Se deficiency converge on the neurobehavioral outcome in mice. Neurotoxicol Teratol. 1999 ; 21 : 83-88. (10) Spyker JM, Sparber SB, Goldberg AM. Subtle consequences of methylmercury exposure: behavioral deviations in offspring of treated mothers. Science. 1972 ; 177 : 621-623. (34) Yoshida M, Satoh H, Aoyama H, Kojima S, Yamamura Y. Distribution of mercury in neonatal guinea pigs after exposure to mercury vapor. Bull Environ Contam Toxicol. 1989 ; 43 : 697-704. (26) Nakai K, Okamura K, Kumamoto K, Hosokawa T, Sakai T, Nakamura T, Sukeno N, Satoh H. Effects of perinatal exposure to environmentally persistent organic pollutants and heavy metals on neurobehavioral development in Japanese children: an interim report. Organohalogen Compounds. 2001 ; 53 : 254-255. (11) Shimai S, Satoh H, Yasuda N. Taste aversion learning and perinatal methylmercury exposure in mice. Ind Health. 1984 ; 22 : 41-44. (7) Satoh H, Suzuki T. Embryonic and fetal death after in utero methylmercury exposure and resultant organ mercury concentrations in mice. Ind Health. 1983 ; 21 : 19-24. (14) Shimai S, Satoh H. Behavioral teratology of methylmercury. J Toxicol Sci. 1985 ; 10 : 199-216. (29) Suzuki K, Nakai K, Oka T, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Satoh H. Effect of perinatal exposure to environmentally persistent organic pollutants and heavy metals on neurobehavioral development in Japanese children: IV. Thyroid hormones and neonatal neurobehavioral status. Organohalogen Compounds. 2004 ; 66 : 3150-3156. (22) Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997 ; 19 : 417-428. (23) Debes F, Budtz-Jorgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol. 2006 ; 28 : 536-547. (28) Nakai K, Oka T, Suzuki K, Okamura K, Hosokawa T, Sakai T, Nakamura T, Takahashi M, Satoh H. Effects of perinatal exposure to environmentally persistent organic pollutants and heavy metals on neurobehavioral development in Japanese children: II. Protocol and description of study cohort. Organohalogen Compounds. 2002 ; 59 : 389-390. (30) Nakai K, Suzuki K, Oka T, Murata K, Sakamoto M, Okamura K, Hosokawa T, Sakai T, Nakamura T, Saito Y, Kurokawa N, Kameo S, Satoh H. The Tohoku Study of Child Development: a cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children. Tohoku J Exp Med. 2004 ; 202 : 227-237. (18) Watanabe C, Yoshida K, Kasanuma Y, Yin K, Satoh H. In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain. Environ Res. 1999 ; 80 : 208-214. (21) Kim C-Y, Nakai K, Kasanuma Y, Satoh H. Comparison of neurobehavioral changes in three inbred strains of mice prenatally exposed to methylmercury. Neurotoxicol Teratol. 2000 ; 22 : 397-403. (43) Watanabe C, Satoh H. Evolution of our understanding of methylmercury as a health threat. Environ Health Perspect. 1996 ; 104 Suppl. 2 : 367-379. (6) Satoh H, Suzuki T. Effects of sodium selenite on methylmercury distribution in mice of late gestational period. Arch Toxicol. 1979 ; 42 : 275-279. (41) Naganuma A, Satoh H, Yamamoto R, Suzuki T, Imura N. Effects of selenium on determination of mercury in animal tissues. Anal Biochem. 1979 ; 98 : 287-292. (45) Satoh H. Behavioral teratology of mercury and its compounds. Tohoku J Exp Med. 2003 ; 201 : 1-9. (33) Yoshida M, Aoyama H, Satoh H, Yamamura Y. Binding of mercury to metallothinein-like protein in fetal liver of the guinea pig following in utero exposure to mercury vapor. Toxicol Lett. 1987 ; 37 : 1-6. (38) Kishi R, Doi R, Fukuchi Y, Satoh H, Satoh T, Ono A, Moriwaka F, Tashiro K, Takahata N. Subjective symptoms and neurobehavioral performances of ex-mercury miners at an average of 18 years after the cessation of chronic exposure to mercury vapor. Environ Res. 1993 ; 62 : 289-302. (25) Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari E, Sloane-Reeves J, Wilding GE, Kost J, Huang L-S, Clarkson TW. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet. 2003 ; 361 : 1686-1692. |
| References_xml | – reference: (17) Watanabe C, Yin K, Kasanuma Y, Satoh H. In utero exposure to methylmercury and Se deficiency converge on the neurobehavioral outcome in mice. Neurotoxicol Teratol. 1999 ; 21 : 83-88. – reference: (29) Suzuki K, Nakai K, Oka T, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Satoh H. Effect of perinatal exposure to environmentally persistent organic pollutants and heavy metals on neurobehavioral development in Japanese children: IV. Thyroid hormones and neonatal neurobehavioral status. Organohalogen Compounds. 2004 ; 66 : 3150-3156. – reference: (10) Spyker JM, Sparber SB, Goldberg AM. Subtle consequences of methylmercury exposure: behavioral deviations in offspring of treated mothers. Science. 1972 ; 177 : 621-623. – reference: (5) Ganther HE, Goudie C, Sunde ML, Kopecky MJ, Wagner P. Selenium: relation to decreased toxicity of methylmercury added to diets containing tuna. Science. 1972 ; 175 : 1122-1124. – reference: (1) 佐藤 洋. 水銀. 佐藤 洋編著. Toxicology Today中毒学から生体防御の科学へ. 京都 : 金芳堂, 1994 : 71-78. – reference: (20) Sugawara N, Nakai K, Kameo S, Ohba T, Shimada M, Satoh H. Lesson from an animal experiment of combined exposures to methylmercury and PCBs on neurobehavioral influences in mice. Abstract Book of NIMD Forum 2006, 5. – reference: (32) Yoshida M, Yamamura Y, Satoh H. Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation. Arch Toxicol. 1986 ; 58 : 225-228. – reference: (38) Kishi R, Doi R, Fukuchi Y, Satoh H, Satoh T, Ono A, Moriwaka F, Tashiro K, Takahata N. Subjective symptoms and neurobehavioral performances of ex-mercury miners at an average of 18 years after the cessation of chronic exposure to mercury vapor. Environ Res. 1993 ; 62 : 289-302. – reference: (18) Watanabe C, Yoshida K, Kasanuma Y, Yin K, Satoh H. In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain. Environ Res. 1999 ; 80 : 208-214. – reference: (12) Satoh H, Yasuda N, Shimai S. Development of reflexes in neonatal mice perinatally exposed to methylmercury and selenite. Toxicol Lett. 1985 ; 25 : 199-203. – reference: (9) Werboff J, Havlena J. Postnatal behavioral effects of tranquilizers administered to the gravid rat. Exp Neurol. 1962 ; 6 : 263-269. – reference: (19) Sugawara N, Nakai K, Nakamura T, Ohba T, Suzuki K, Kameo S, Satoh C, Satoh H. Developmental and neurobehavioral effects of perinatal exposure to polychlorinated biphenyls in mice. Arch Toxicol. 2006 ; 80 : 286-292. – reference: (34) Yoshida M, Satoh H, Aoyama H, Kojima S, Yamamura Y. Distribution of mercury in neonatal guinea pigs after exposure to mercury vapor. Bull Environ Contam Toxicol. 1989 ; 43 : 697-704. – reference: (15) Shimai S, Satoh H. Behavioral teratogenesis of heavy metals: Problems in experimental researches. Congenital Anomaly. 1985 ; 25 : 367-376. – reference: (26) Nakai K, Okamura K, Kumamoto K, Hosokawa T, Sakai T, Nakamura T, Sukeno N, Satoh H. Effects of perinatal exposure to environmentally persistent organic pollutants and heavy metals on neurobehavioral development in Japanese children: an interim report. Organohalogen Compounds. 2001 ; 53 : 254-255. – reference: (35) Yoshida M, Satoh H, Kojima S, Yamamura Y. Retention and distribution of mercury in organs of neonatal guinea pigs after in utero exposure to mercury vapor. Journal of Trace Elements in Experimental Medicine. 1990 ; 3 : 219-226. – reference: (2) Broad WJ. Sir Isaac Newton: mad as a hatter. Science. 1981 ; 213 : 1341-2, 1344. – reference: (40) Yoshida M, Watanabe C, Satoh H, Kishimoto T, Yamamura Y. Milk transfer and tissue uptake of mercury in suckling offspring after exposure of lactating maternal guinea pigs to inorganic or methylmercury. Arch Toxicol. 1994 ; 68 : 174-178. – reference: (4) 食品安全委員会. 魚介類等に含まれるメチル水銀について. http://www.fsc.go.jp/hyouka/iken.html#04/hy-hyoukamethylmercury.pdf – reference: (13) Satoh H, Shimai S, Yasuda N. Mercury metabolism and development of mice offspring perinatally exposed to methylmercury and selenite. Nutr Res. 1985 ; Supplement I : 580-586. – reference: (30) Nakai K, Suzuki K, Oka T, Murata K, Sakamoto M, Okamura K, Hosokawa T, Sakai T, Nakamura T, Saito Y, Kurokawa N, Kameo S, Satoh H. The Tohoku Study of Child Development: a cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children. Tohoku J Exp Med. 2004 ; 202 : 227-237. – reference: (8) Nobunaga T, Satoh H, Suzuki T. Effects of sodium selenite on methylmercury embryotoxicity and tertogenicity. Toxicol Appl Pharmacol. 1979 ; 47 : 79-88. – reference: (37) Yoshida M, Satoh H, Kishimoto T, Yamamura Y. Exposure to mercury via breast milk in suckling offspring of maternal guinea pigs exposed to mercury vapor after parturition. J Toxicol Environ Health. 1992 ; 35 : 135-139. – reference: (22) Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997 ; 19 : 417-428. – reference: (6) Satoh H, Suzuki T. Effects of sodium selenite on methylmercury distribution in mice of late gestational period. Arch Toxicol. 1979 ; 42 : 275-279. – reference: (11) Shimai S, Satoh H, Yasuda N. Taste aversion learning and perinatal methylmercury exposure in mice. Ind Health. 1984 ; 22 : 41-44. – reference: (43) Watanabe C, Satoh H. Evolution of our understanding of methylmercury as a health threat. Environ Health Perspect. 1996 ; 104 Suppl. 2 : 367-379. – reference: (7) Satoh H, Suzuki T. Embryonic and fetal death after in utero methylmercury exposure and resultant organ mercury concentrations in mice. Ind Health. 1983 ; 21 : 19-24. – reference: (45) Satoh H. Behavioral teratology of mercury and its compounds. Tohoku J Exp Med. 2003 ; 201 : 1-9. – reference: (39) Kishi R, Doi R, Fukuchi Y, Satoh H, Satoh T, Ono A, Moriwaka F, Tashiro K, Takahata N, Sasatani H, Shirakashi H, Kamada T, Nakagawa K. Residual neurobehavioural effects associated with chronic exposure to mercury vapour. Occup Environ Med. 1994 ; 51 : 35-41. – reference: (41) Naganuma A, Satoh H, Yamamoto R, Suzuki T, Imura N. Effects of selenium on determination of mercury in animal tissues. Anal Biochem. 1979 ; 98 : 287-292. – reference: (44) Satoh H. Occupational and environmental toxicology of mercury and its compounds. Ind Health. 2000 ; 38 : 153-164. – reference: (16) Yin K, Watanabe C, Inaba H, Satoh H. Growth and behavioral changes in mice prenatally exposed to methylmercury and heat. Neurotoxicol Teratol. 1997 ; 19 : 1-7. – reference: (21) Kim C-Y, Nakai K, Kasanuma Y, Satoh H. Comparison of neurobehavioral changes in three inbred strains of mice prenatally exposed to methylmercury. Neurotoxicol Teratol. 2000 ; 22 : 397-403. – reference: (23) Debes F, Budtz-Jorgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol. 2006 ; 28 : 536-547. – reference: (27) Nakai K, Satoh H. Developmental neurotoxicity following prenatal exposures to methylmercury and PCBs in humans from epidemiological studies. Tohoku J Exp Med. 2002 ; 196 : 89-98. – reference: (42) Yamamoto R, Satoh H, Suzuki T, Naganuma A, Imura N. The applicable condition of Magos' method for mercury measurement under coexistence of selenium. 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| Snippet | I would like to express sincere thanks to all the people involved in awarding the 2005 Congress Award. It is a great honor to be given the prize. I have been... |
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| SubjectTerms | Animals Behavior - drug effects behavioral teratology Environmental Pollutants - poisoning Female Fishes Food Contamination Humans methylmercury Methylmercury Compounds - poisoning Pregnancy Prenatal Exposure Delayed Effects risk assessment |
| Title | My Experience in Mercury Toxicology: Behavioral Teratology Study of the Effects of Prenatal Exposure to Environmental Pollutants |
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