OECD化学物質対策の動向(第3報)(Topics on Regulatory Toxicology (15))
1998年10月に第8回, 1999年6～7月に第9回のOECD高生産量化学物質初期評価会議が行われた。日本からはそれぞれ4物質および6物質の初期評価文書を提出, 発表し, その結果, 第8回会議では3物質(benzyl chloride, pentaerythritol, 2, 6-dichlorotoluene), また, 第9回会議では4物質(isocyanuric acid, 2, 2 azobis(2-methylpropionitrile), dimethyl 2, 6-naphthalenedicarboxylate, 4-hydroxybenzoic acid)の評価結果につい...
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| Published in | Journal of toxicological sciences Vol. 25; no. 2; pp. App83 - App96 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本毒性学会
11.05.2000
|
| Online Access | Get full text |
| ISSN | 0388-1350 1880-3989 |
| DOI | 10.2131/jts.25.App83 |
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| Abstract | 1998年10月に第8回, 1999年6～7月に第9回のOECD高生産量化学物質初期評価会議が行われた。日本からはそれぞれ4物質および6物質の初期評価文書を提出, 発表し, その結果, 第8回会議では3物質(benzyl chloride, pentaerythritol, 2, 6-dichlorotoluene), また, 第9回会議では4物質(isocyanuric acid, 2, 2 azobis(2-methylpropionitrile), dimethyl 2, 6-naphthalenedicarboxylate, 4-hydroxybenzoic acid)の評価結果について合意が得られた。本稿では, 第8および9回会議で合意の得られた上記7物質の初期評価文書のヒトへの健康影響部分について, その要旨を紹介し, 続いて, benzyl chlorideとisocyanuric acidについてはその内容について紹介した。Benzyl chlorideは日本から提出された物質としては初めて"今後の対策が必要"との結論になったものであり, isocyanuric acidについては, 消費者暴露が明確であり, 暴露シナリオを用いてリスクが評価された。 |
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| AbstractList | 1998年10月に第8回, 1999年6～7月に第9回のOECD高生産量化学物質初期評価会議が行われた。日本からはそれぞれ4物質および6物質の初期評価文書を提出, 発表し, その結果, 第8回会議では3物質(benzyl chloride, pentaerythritol, 2, 6-dichlorotoluene), また, 第9回会議では4物質(isocyanuric acid, 2, 2 azobis(2-methylpropionitrile), dimethyl 2, 6-naphthalenedicarboxylate, 4-hydroxybenzoic acid)の評価結果について合意が得られた。本稿では, 第8および9回会議で合意の得られた上記7物質の初期評価文書のヒトへの健康影響部分について, その要旨を紹介し, 続いて, benzyl chlorideとisocyanuric acidについてはその内容について紹介した。Benzyl chlorideは日本から提出された物質としては初めて"今後の対策が必要"との結論になったものであり, isocyanuric acidについては, 消費者暴露が明確であり, 暴露シナリオを用いてリスクが評価された。 |
| Author | 黒川, 雄二 菅野, 誠一郎 高月, 峰夫 長谷川, 隆一 小泉, 睦子 鎌田, 栄一 広瀬, 明彦 |
| Author_xml | – sequence: 1 fullname: 菅野, 誠一郎 – sequence: 1 fullname: 黒川, 雄二 – sequence: 1 fullname: 鎌田, 栄一 – sequence: 1 fullname: 長谷川, 隆一 – sequence: 1 fullname: 小泉, 睦子 – sequence: 1 fullname: 広瀬, 明彦 – sequence: 1 fullname: 高月, 峰夫 |
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| References | Landsteiner, K. and Jacobs, J. (1936): Studies on the sensitization of animals with simple chemical compounds. II. J. Exp. Med., 64, 625-639. Wheeler, A. G., Barbee, S. J., Hammond, B. G., Inoue, T., Ishida, N., Cascieri, T. and Schardein, J.L. (1985): Three generation reproduction study in rats administered cyanurate. Toxicologist, 5, 189. Skowronski, G. and Abdel Rahman, M. S. (1986): Teratogenicity of benzyl chloride in the rat. J. Toxicol. Environ. Health, 17, 51-56. Booth, S.C., Mould, A. J., Shaw, A. and Garner, R. C. (1983): The biological activity of 4-chloromethylbiphenyl, benzyl chloride and 4-hydroxymethylbiphenyl in 4 short-term tests for carcinogenicity. A report of an individual study in the UKEMS genotoxicity trial 1981. Mutat. Res. 119, 121-133. 厚生省(1997d): 化学物質毒性試験報告 (2, 6-ナフタレンジカルボン酸ジメチルエステル: CAS 840-65-3) vol.5, pp.499-524, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. Hammond, B. G., Barbee, S. J., Wheeler, A. G. and Cascieri, T. (1985): Absence of mutagenic activity for monosodium cyanurate. Fundam. Appl. Toxicol., 5, 655-664. Industry Ad hoc Committee for Isocyanurates (1981b): SRI International, Project LSC 2923, Task 1. 厚生省(1997c): 化学物質毒性試験報告 (イソシアヌル酸: CAS 108-80-5) vol.5, pp.407-428, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. Ashby, J., Gaunt, C. and Robinson, M. (1982): Carcinogenicity bioassay of 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB) and benzyl chloride (BC) on mouse skin: Interim (7 month) report. Mutat. Res., 100, 399-401. Hartley, A. B. (1982) :Investigation of the cytogenetic effects of BC and 4CMB on human peripheral lymphocytes in vitro. Mutat. Res., 100, 295-296. Sobti, R. C., Krishan, A. and Pfaffenberger, C. D. (1981): Cytogenetic monitoring of environmental pollutants in South Florida, AACR Abstracts, 435. 厚生省(1997b): 化学物質毒性試験報告 (4-ヒドロキシ安息香酸: CAS99-96-7) vol.5, pp.247-274, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. Allen, M. L., Briggle, T. V. and Pfaffenberger, C. D. (1982): Absorption and excretion of cyanuric acid in long-distance swimmers. Drug Metab. Rev., 13, 499-516. Fahmy, M. J. and Fahmy, O. G. (1982): Genetic activities of 4-chloromethylbiphenyl, the 4-hydroxy derivative and benzyl chloride in the soma and germ line of Drosophila melanogaster. Mutat. Res., 100, 339-344. Lijinsky, W. (1986): Chronic bioassay of benzyl chloride in F344 rats and (C57BL 6J×BALB c) F1 mice. J. Natl. Cancer Inst, 76, 1231-1237. NORSOLOR APC (1977): Inductest performed by Institut Pasteur de Paris (M. Hofnung) , Contract 133. Cascieri, T., Barbee, S. J., Hammond, B. G., Inoue, T., Ishida, N. and Wheeler, A. G. (1985): Comprehensive evaluation of the urinary tract after chronic exposure to cyanurate in drinking water. Toxicologist, 5, 58. North, T. A. and Parry, J. M. (1982): A comparison of the response to 4CMB, 4HMB and BC of 5 yeast strains differing in their radiosensitivities. Mutat. Res. 100, 113-117. Druckrey, H., Kruse, H., Preussmann, R., Ivankovic, S. and Landschutz, C. (1970): Cancerogenic alkylating substances. 3. Alkyl-halogenides, -sulfates, -sulfonates and strained heterocyclic compounds. Z. Krebsforsch. Klin. Onkol. Cancer Res. Clin. Oncol., 74, 241-273. Barbee, S. J., Cascieri, T., Hammond, B. G., Inoue, T., Ishida, N., Wheeler, A. G., Chadwick, M., Hayes, D., Macauley, J. and McComish, A. (1983): Metabolism and disposition of sodium cyanurate. Toxicologist, 3, 80. Schmuck, G., Lieb, G., Wild, D., Schiffmann, D. and Henschler, D. (1988): Characterization of an in vitro micronucleus assay with Syrian hamster embryo fibroblasts. Mutat. Res., 203, 397-404. 長谷川隆一, 鎌田栄一, 広瀬明彦, 菅野誠一郎, 福間康之臣, 高月峰夫, 中舘正弘, 黒川雄二(1999b): OECD化学物質対策の動向(第2報). J. Toxicol. Sci., 24, app. 85-92. Hemminki, K., Falck, K. and Linnainmaa, K. (1983): Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives. J. Appl. Toxicol., 3, 203-207. 厚生省(2000): 化学物質毒性試験報告 (2, 6-ジクロロトルエン: CAS 118-69-4) 印刷中, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. Datta, P. R. (1979): Hazard Evaluation Division Report prepared for Special Pesticide Review Division, p1. Golaszewski, G. and Seux, R. (1994): He kinetics of the action of chloroisocyanurates on three bacteria: Pseudomonas aeruginosa, Streptococcus faecalis and Staphylococcus aureus. Water Res., 28, 207-217. von Oettigen, W. F. (1955): The halogenated aliphatic, olefinic, cyclic, aromatic and aliphaticaromatic hydrocarbons including the halogenated insecticides, their toxicity and potential dangers. Pp. 300-302. Hodge, H. C., Panner, B. J., Downs, W. L. and Maynard, E. A. (1965): Toxicity of sodium cyanurate. Toxicol. Appl. Pharmacol., 7, 667-674. FMC Corporation (1972) : Industrial Bio Test, Report E 756. Coombs, M. M. (1982a) : Attempts to initiate skin tumours in mice in the 2-stage system using 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB), and benzyl chloride (BC). Report of the experiment at 10 months. Mutat. Res., 100, 403-405. Mikhailova, T. V. (1964): Comparative toxicity of chlorous toluene compounds-benzyl chloride, benzal chloride and benzotrichloride. Gig. Tr. Prof. Zabol., 8, 14-19. Hammond, B. G., Barbee, S. J., Inoue, T., Ishida, N., Levinskas, G. J., Stevens, M. W., Wheeler, A. G. and Cascieri, T. (1986): A review of toxicology studies on cyanurate and its chlorinated derivatives. Environ. Health Perspect., 69, 287-292. Poirier, L. A., Stoner, G. D. and Shimkin, M. B. (1975): Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice. Cancer Res., 35, 1411-1415. Haworth, S., Lawlor, T., Mortelmans, K., Speck, W. and Zeiger, E. (1983): Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen., 5, Suppl 1, 1-142. Coombs, M. M. (1982b): The UKEMS genotoxicity trial. A summary of the assays for skin tumour induction in mice, the subcutaneous implant test and the sebaceous gland suppression test. Mutat. Res., 100, 407-409. Industry Ad hoc Committee for Isocyanurates (1986): Hazleton laboratories, Report 2169. Fukuda, K., Matsushita, H., Sakabe, H. and Takemoto, K. (1981): Carcinogenicity of benzyl chloride, benzal chloride, benzotrichloride and benzoyl chloride in mice by skin application. Gann, 72, 655-664. Moody, R. P. (1993): In vitro dermal absorption of pesticides: A cross-species comparison including test skin. J. Toxicol., Cutaneous Ocul. Toxicol., 12, 197-202. Danford, N. and Parry, J. M. (1982): The effects of 4CMB, 4HMB and BC in the micronucleus test. Mutat. Res., 100, 353-356. Scott, K. and Topham, J. C. (1982): Sperm head abnormality test. Mutat. Res., 100, 345-350. Venitt, S., Crofton Sleigh, C. and Bosworth, D. A. (1982): UKEMS trial: Bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2 uvrA (pKM101) and S. typhimurium TA98 and TA100. Mutat. Res., 100, 39-43. 長谷川隆一, 中舘正弘, 黒川雄二 (1999a): OECD化学物質対策の動向. J. Toxicol. Sci., 24, app. 11-19. 厚生省 (1997a): 化学物質毒性試験報告 (2, 2'-アゾビス (2-メチルプロピオニトリル): CAS78-67-1) vol.5, pp.65-94, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. Zissu, D. (1995): Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals. J. Appl. Toxicol. 15, 207-213. Hoy, C. A., Salazar, E. P. and Thompson, L. H. (1984): Rapid detection of DNA-damaging agents using repair-deficient CHO cells. Mutat. Res., 130, 321-332. Babayan, A. A - and Aleksandryan, A. V. (1985) Toxicological characteristics of melamine cyanurate, melamine and cyanuric acid. Zh. Eksp. Klin. Med., 25, 345. Toxikologische Bewertung (1993): Heidelberg, Berufsgenossenschaft der chemischen Industrie, 103, 28p. Indutry Ad hoc Committee for Isocyanurates (1981a): Research Institute Int., Project 013-312-582-7. 厚生省(1995): 化学物質毒性試験報告 (ペンタエリスリトール: CAS115-77-5) vol. 3, pp.259-284, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. D'Auria, F. D., Simonetti, G. and Strippoli, V. (1989): Antimicrobial activity exerted by sodium ichloroisocyanurate. Ann. Ig., 1, 1445-1458. Hazleton, U. S. (Vienna) (1982): Thirteen week toxicity study in mice - Sodium monocyanurate, Report 2169. Mirzayans, F., Davies, P. J. and Parry, J. M. (1982): The cytotoxic and mutagenic effects of 4CMB, BC and 4HMB in V79 Chinese hamster cells. Mutat. Res. 100, 239-244. |
| References_xml | – reference: Golaszewski, G. and Seux, R. (1994): He kinetics of the action of chloroisocyanurates on three bacteria: Pseudomonas aeruginosa, Streptococcus faecalis and Staphylococcus aureus. Water Res., 28, 207-217. – reference: 長谷川隆一, 中舘正弘, 黒川雄二 (1999a): OECD化学物質対策の動向. J. Toxicol. Sci., 24, app. 11-19. – reference: North, T. A. and Parry, J. M. (1982): A comparison of the response to 4CMB, 4HMB and BC of 5 yeast strains differing in their radiosensitivities. Mutat. Res. 100, 113-117. – reference: Skowronski, G. and Abdel Rahman, M. S. (1986): Teratogenicity of benzyl chloride in the rat. J. Toxicol. Environ. Health, 17, 51-56. – reference: Hartley, A. B. (1982) :Investigation of the cytogenetic effects of BC and 4CMB on human peripheral lymphocytes in vitro. Mutat. Res., 100, 295-296. – reference: D'Auria, F. D., Simonetti, G. and Strippoli, V. (1989): Antimicrobial activity exerted by sodium ichloroisocyanurate. Ann. Ig., 1, 1445-1458. – reference: von Oettigen, W. F. (1955): The halogenated aliphatic, olefinic, cyclic, aromatic and aliphaticaromatic hydrocarbons including the halogenated insecticides, their toxicity and potential dangers. Pp. 300-302. – reference: Indutry Ad hoc Committee for Isocyanurates (1981a): Research Institute Int., Project 013-312-582-7. – reference: NORSOLOR APC (1977): Inductest performed by Institut Pasteur de Paris (M. Hofnung) , Contract 133. – reference: Industry Ad hoc Committee for Isocyanurates (1986): Hazleton laboratories, Report 2169. – reference: Venitt, S., Crofton Sleigh, C. and Bosworth, D. A. (1982): UKEMS trial: Bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2 uvrA (pKM101) and S. typhimurium TA98 and TA100. Mutat. Res., 100, 39-43. – reference: Zissu, D. (1995): Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals. J. Appl. Toxicol. 15, 207-213. – reference: Datta, P. R. (1979): Hazard Evaluation Division Report prepared for Special Pesticide Review Division, p1. – reference: 厚生省(1997d): 化学物質毒性試験報告 (2, 6-ナフタレンジカルボン酸ジメチルエステル: CAS 840-65-3) vol.5, pp.499-524, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. – reference: Hemminki, K., Falck, K. and Linnainmaa, K. (1983): Reactivity, SCE induction and mutagenicity of benzyl chloride derivatives. J. Appl. Toxicol., 3, 203-207. – reference: 厚生省(2000): 化学物質毒性試験報告 (2, 6-ジクロロトルエン: CAS 118-69-4) 印刷中, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. – reference: Landsteiner, K. and Jacobs, J. (1936): Studies on the sensitization of animals with simple chemical compounds. II. J. Exp. Med., 64, 625-639. – reference: Poirier, L. A., Stoner, G. D. and Shimkin, M. B. (1975): Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice. Cancer Res., 35, 1411-1415. – reference: Coombs, M. M. (1982a) : Attempts to initiate skin tumours in mice in the 2-stage system using 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB), and benzyl chloride (BC). Report of the experiment at 10 months. Mutat. Res., 100, 403-405. – reference: Coombs, M. M. (1982b): The UKEMS genotoxicity trial. A summary of the assays for skin tumour induction in mice, the subcutaneous implant test and the sebaceous gland suppression test. Mutat. Res., 100, 407-409. – reference: 厚生省 (1997a): 化学物質毒性試験報告 (2, 2'-アゾビス (2-メチルプロピオニトリル): CAS78-67-1) vol.5, pp.65-94, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. – reference: Booth, S.C., Mould, A. J., Shaw, A. and Garner, R. C. (1983): The biological activity of 4-chloromethylbiphenyl, benzyl chloride and 4-hydroxymethylbiphenyl in 4 short-term tests for carcinogenicity. A report of an individual study in the UKEMS genotoxicity trial 1981. Mutat. Res. 119, 121-133. – reference: Danford, N. and Parry, J. M. (1982): The effects of 4CMB, 4HMB and BC in the micronucleus test. Mutat. Res., 100, 353-356. – reference: Mikhailova, T. V. (1964): Comparative toxicity of chlorous toluene compounds-benzyl chloride, benzal chloride and benzotrichloride. Gig. Tr. Prof. Zabol., 8, 14-19. – reference: Toxikologische Bewertung (1993): Heidelberg, Berufsgenossenschaft der chemischen Industrie, 103, 28p. – reference: Wheeler, A. G., Barbee, S. J., Hammond, B. G., Inoue, T., Ishida, N., Cascieri, T. and Schardein, J.L. (1985): Three generation reproduction study in rats administered cyanurate. Toxicologist, 5, 189. – reference: Druckrey, H., Kruse, H., Preussmann, R., Ivankovic, S. and Landschutz, C. (1970): Cancerogenic alkylating substances. 3. Alkyl-halogenides, -sulfates, -sulfonates and strained heterocyclic compounds. Z. Krebsforsch. Klin. Onkol. Cancer Res. Clin. Oncol., 74, 241-273. – reference: Barbee, S. J., Cascieri, T., Hammond, B. G., Inoue, T., Ishida, N., Wheeler, A. G., Chadwick, M., Hayes, D., Macauley, J. and McComish, A. (1983): Metabolism and disposition of sodium cyanurate. Toxicologist, 3, 80. – reference: Hazleton, U. S. (Vienna) (1982): Thirteen week toxicity study in mice - Sodium monocyanurate, Report 2169. – reference: Allen, M. L., Briggle, T. V. and Pfaffenberger, C. D. (1982): Absorption and excretion of cyanuric acid in long-distance swimmers. Drug Metab. Rev., 13, 499-516. – reference: Hodge, H. C., Panner, B. J., Downs, W. L. and Maynard, E. A. (1965): Toxicity of sodium cyanurate. Toxicol. Appl. Pharmacol., 7, 667-674. – reference: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W. and Zeiger, E. (1983): Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen., 5, Suppl 1, 1-142. – reference: Schmuck, G., Lieb, G., Wild, D., Schiffmann, D. and Henschler, D. (1988): Characterization of an in vitro micronucleus assay with Syrian hamster embryo fibroblasts. Mutat. Res., 203, 397-404. – reference: Ashby, J., Gaunt, C. and Robinson, M. (1982): Carcinogenicity bioassay of 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB) and benzyl chloride (BC) on mouse skin: Interim (7 month) report. Mutat. Res., 100, 399-401. – reference: Mirzayans, F., Davies, P. J. and Parry, J. M. (1982): The cytotoxic and mutagenic effects of 4CMB, BC and 4HMB in V79 Chinese hamster cells. Mutat. Res. 100, 239-244. – reference: Fahmy, M. J. and Fahmy, O. G. (1982): Genetic activities of 4-chloromethylbiphenyl, the 4-hydroxy derivative and benzyl chloride in the soma and germ line of Drosophila melanogaster. Mutat. Res., 100, 339-344. – reference: 厚生省(1997b): 化学物質毒性試験報告 (4-ヒドロキシ安息香酸: CAS99-96-7) vol.5, pp.247-274, 厚生省生活衛生局企画課生活化学安全対策室監修, 化学物質点検推進協議会発行. – reference: Cascieri, T., Barbee, S. J., Hammond, B. G., Inoue, T., Ishida, N. and Wheeler, A. G. (1985): Comprehensive evaluation of the urinary tract after chronic exposure to cyanurate in drinking water. 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| Snippet | 1998年10月に第8回, 1999年6～7月に第9回のOECD高生産量化学物質初期評価会議が行われた。日本からはそれぞれ4物質および6物質の初期評価文書を提出, 発表し, その結果, 第8回会議では3物質(benzyl chloride, pentaerythritol, 2,... |
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| Title | OECD化学物質対策の動向(第3報)(Topics on Regulatory Toxicology (15)) |
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