脊髄損傷後の歩行機能回復に向けた新しいビジョン 神経の再生・修復から機能回復まで

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Published in脊髄外科 Vol. 27; no. 2; pp. 125 - 129
Main Authors 河島, 則天, 緒方, 徹
Format Journal Article
LanguageJapanese
Published 日本脊髄外科学会 2013
Subjects
Online AccessGet full text
ISSN0914-6024
1880-9359
DOI10.2531/spinalsurg.27.125

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Author 緒方, 徹
河島, 則天
Author_FL KAWASHIMA Noritaka
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  fullname: 緒方, 徹
  organization: 国立障害者リハビリテーションセンター研究所運動機能系障害研究部
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DocumentTitleAlternate A New Approach for the Restoration of Locomotor Function after Spinal Cord Injury
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References 8) Pearson KG : Proprioceptive regulation of locomotion. Curr Opinion Neurobiol 5 : 786-791, 1995
11) Dobkin BH, Harkema S, Requeio P, et al : Modulation of locomotor-like EMG activity in subjects with complete and incomplete spinal cord injury. J Neuro Rehab 119 : 183-190, 1995
10) Kawashima N, Nozaki D, Abe OM, et al : Alternative leg movements amplify locomotor-like muscle activity in spinal cord injured persons. J Neurophysiol 93 : 777-785, 2005
4) Tsuji O, Miura K, Okada Y, et al : Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci 107 : 12704-12709, 2010
1) Raineteau O, Schwab ME : Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci 2 : 263-273, 2001
13) Dietz V, Müller R, Colombo G, et al : Locomotor activity in spinal man : significance of afferent input from joint and load receptors. Brain 125 : 2626-2634, 2002
6) Courtine G, Song B, Roy RR, et al : Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat Med 14 : 69-74, 2008
3) Zörner B, Schwab ME : Anti-Nogo on the go : from animal models to a clinical trial. Ann N Y Acad Sci 1198 (Suppl 1) : E22-34, 2010
12) Dietz V, Colombo G, Jensen L, et al : Locomotor activity in spinal man. Lancet 344 : 1260-1263, 1994
15) Gorassini MA, Norton JA, Nevett-Duchcherer J, et al : Changes in locomotor muscle activity after treadmill training in subjects with incomplete spinal cord injury. J Neurophysiol 101 : 969-979, 2009
17) Colombo G, Wirz M, Dietz V, et al : Driven gait orthosis for improvement of locomotor training in paraplegic patients. Spinal Cord 39 : 252-255, 2001
5) Iwatsuki K, Yoshimine T, Kishima H, et al : Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats. Neuroreport 19 : 1249-1252, 2008
7) Wickelgren I : Teaching the spinal cord to walk. Science 279 : 319-321, 1998
16) Yang JF, Norton J, Nevett-Duchcherer J, et al : Volitional muscle strength in the legs predicts changes in walking speed following locomotor training in people with chronic spinal cord injury. Phys Ther 91 : 931-943, 2011
14) Dobkin BH, Apple D, Barbeau H, et al : Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI. Neurology 66 : 484-493, 2006
2) David S, Aguayo AJ : Axonal elongation into peripheral nervous system “bridges” after central nervous system injury in adult rats. Science 214 : 931-933, 1981
9) Harkema SJ, Hurley SL, Patel UK, et al : Human lumbosacral spinal cord interprets loading during stepping. J Neurophysiol 77 : 797-811, 1997
References_xml – reference: 6) Courtine G, Song B, Roy RR, et al : Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat Med 14 : 69-74, 2008
– reference: 4) Tsuji O, Miura K, Okada Y, et al : Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci 107 : 12704-12709, 2010
– reference: 14) Dobkin BH, Apple D, Barbeau H, et al : Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI. Neurology 66 : 484-493, 2006
– reference: 7) Wickelgren I : Teaching the spinal cord to walk. Science 279 : 319-321, 1998
– reference: 11) Dobkin BH, Harkema S, Requeio P, et al : Modulation of locomotor-like EMG activity in subjects with complete and incomplete spinal cord injury. J Neuro Rehab 119 : 183-190, 1995
– reference: 16) Yang JF, Norton J, Nevett-Duchcherer J, et al : Volitional muscle strength in the legs predicts changes in walking speed following locomotor training in people with chronic spinal cord injury. Phys Ther 91 : 931-943, 2011
– reference: 2) David S, Aguayo AJ : Axonal elongation into peripheral nervous system “bridges” after central nervous system injury in adult rats. Science 214 : 931-933, 1981
– reference: 8) Pearson KG : Proprioceptive regulation of locomotion. Curr Opinion Neurobiol 5 : 786-791, 1995
– reference: 17) Colombo G, Wirz M, Dietz V, et al : Driven gait orthosis for improvement of locomotor training in paraplegic patients. Spinal Cord 39 : 252-255, 2001
– reference: 3) Zörner B, Schwab ME : Anti-Nogo on the go : from animal models to a clinical trial. Ann N Y Acad Sci 1198 (Suppl 1) : E22-34, 2010
– reference: 13) Dietz V, Müller R, Colombo G, et al : Locomotor activity in spinal man : significance of afferent input from joint and load receptors. Brain 125 : 2626-2634, 2002
– reference: 1) Raineteau O, Schwab ME : Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci 2 : 263-273, 2001
– reference: 12) Dietz V, Colombo G, Jensen L, et al : Locomotor activity in spinal man. Lancet 344 : 1260-1263, 1994
– reference: 5) Iwatsuki K, Yoshimine T, Kishima H, et al : Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats. Neuroreport 19 : 1249-1252, 2008
– reference: 9) Harkema SJ, Hurley SL, Patel UK, et al : Human lumbosacral spinal cord interprets loading during stepping. J Neurophysiol 77 : 797-811, 1997
– reference: 15) Gorassini MA, Norton JA, Nevett-Duchcherer J, et al : Changes in locomotor muscle activity after treadmill training in subjects with incomplete spinal cord injury. J Neurophysiol 101 : 969-979, 2009
– reference: 10) Kawashima N, Nozaki D, Abe OM, et al : Alternative leg movements amplify locomotor-like muscle activity in spinal cord injured persons. J Neurophysiol 93 : 777-785, 2005
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StartPage 125
SubjectTerms 歩行機能回復
神経再生
神経可塑性
脊髄CPG
Subtitle 神経の再生・修復から機能回復まで
Title 脊髄損傷後の歩行機能回復に向けた新しいビジョン
URI https://www.jstage.jst.go.jp/article/spinalsurg/27/2/27_125/_article/-char/ja
https://cir.nii.ac.jp/crid/1573105975978274816
Volume 27
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