An O2 Self‐Supplementing and Reactive‐Oxygen‐Species‐Circulating Amplified Nanoplatform via H2O/H2O2 Splitting for Tumor Imaging and Photodynamic Therapy

• Published in: Advanced functional materials Vol. 27; no. 43
• Main Authors: Zhang, Chi, Chen, Wei‐Hai, Liu, Li‐Han, Qiu, Wen‐Xiu, Yu, Wu‐Yang, Zhang, Xian‐Zheng
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 17.11.2017
• Subjects: Biocompatibility; Decomposition; Hydrogen peroxide; Hydroxyl radicals; hypoxic tumors; Infrared radiation; Magnetic resonance imaging; Manganese dioxide; Materials science; Nanocomposites; Nanostructure; Penetration depth; Photodynamic therapy; reactive oxygen species; Singlet oxygen; Titanium oxides; Upconversion; upconversion nanoparticles; Water splitting

Conventional photodynamic therapy (PDT) has limited applications in clinical cancer therapy due to the insufficient O2 supply, inefficient reactive oxygen species (ROS) generation, and low penetration depth of light. In this work, a multifunctional nanoplatform, upconversion nanoparticles (UCNPs)@Ti...