Lipoprotein(a)の血小板凝集能, 粘着能におよぼす影響

• Published in: 動脈硬化 Vol. 24; no. 12; pp. 825 - 829
• Main Authors: 瀧川, 修, 小熊, 利明, 布施川, 雄一, 安藤, 泰彦, 半田, 俊之介, 多田, 博巳, 玉地, 寛光, 川田, 勉, 椎名, 豊, 後藤, 俊哉
• Format: Journal Article
• Language: Japanese
• Published: 一般社団法人 日本動脈硬化学会 1997; Japan Atherosclerosis Society
• Subjects: Glycoprotein IIb; IIIa complex; Platelet small aggregation formed spontaneously Lipoprotein(a)
• ISSN: 0386-2682; 2185-8284
• DOI: 10.5551/jat1973.24.12_825

Increased plasma level of lipoprotein (a) (Lp(a)) is associated with atherosclerosis and vascular disease. Though it is well known that there is a strong interaction between Lp(a) and resting platelets, there are no clinical studies on the relationship between Lp(a) and platelet adhesion and aggregation. We measured plasma Lp(a) concentration and platelet function in 103 normal volunteers. Small aggregations of platelets that formed spontaneously (SAG) were measured using laser light scattering. Platelet aggregation was measured by Borns method using epinephrine or ADP as an aggregate. There was no significant difference between HLP (subjects with LP(a)>12mg/dl) and LLP (Lp(a)<12mg/dl) by age, mean blood pressure, body mas index, blood glucose, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol concentrations, prothrombin time, activated partial thromboplastin time, fibrinogen or platelet counts. SAG was significantly higher in HLP than in LLP (p=0.0091). There was no significant difference between HLP and LLP in platelet aggregation when either epinephrine or ADP was used as an aggregate. Log (Lp(a)) correlated with log (SAG) positively (r=0.3116, p=0.001). SAG was inhibited by monoclonal anti glycoprotein IIb/IIIa complex anti body. We concluded that platelet glycoprotein and adhesion may contribute to the relationship between Lp(a) and atherosclerosis.