Role of phase 2 drug-metabolizing enzymes modulated by extracts from 78 herbal medicines in detoxification of electrophiles and lung cancer chemotherapy

• Published in: Journal of Traditional Medicines Vol. 27; no. 3; pp. 122 - 133
• Main Authors: Ohnuma, Tomokazu, Matsumoto, Takashi, Komatsu, Takao, Nishiyama, Takahito, Ogura, Kenichiro, Iwata, Hiroshi, Hiratsuka, Akira
• Format: Journal Article
• Language: English
• Published: Medical and Pharmaceutical Society for WAKAN-YAKU 2010
• Subjects: glutathione S-transferase; herbal medicine; NAD(P)H:quinone oxidoreductase 1; Nrf2; phase 2 drug-metabolizing enzyme

Phase 2 drug-metabolizing enzymes (DMEs), such as glutathione S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1), play a major role in the cellular detoxification of pharmaceutical agents and carcinogens. Previously, we reported the inhibitory effects of human liver microsomal cytochrom...