モノクローナル抗体を用いたヒト血小板由来成長因子のラジオイムノアッセイの基礎的検討およびその臨床応用

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Published in動脈硬化 Vol. 17; no. 5; pp. 703 - 707
Main Authors 荻原, 俊男, 大西, 利夫, 白石, 恒人, 森本, 茂人
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本動脈硬化学会 01.10.1989
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ISSN0386-2682
2185-8284
DOI10.5551/jat1973.17.5_703

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Author 大西, 利夫
森本, 茂人
白石, 恒人
荻原, 俊男
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  fullname: 大西, 利夫
  organization: 大阪大学医学部老年病医学講座
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  fullname: 白石, 恒人
  organization: 大阪大学医学部老年病医学講座
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  fullname: 森本, 茂人
  organization: 大阪大学医学部老年病医学講座
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References 1) Ross, R.: Platelet-derived growth factor. Ann. Rev. Med., 38: 71-79 (1987).
16) 杉原圭亮, 益子秀行, 山内忠一, 菅原敏行, 馬場正博: 合成ペプチドを免疫原とした単クローン性抗ヒトPDGF抗体の作成. 動脈硬化, 16: 37-39 (1988).
13) Bowen-Pope, D. F., Malpass, T. W., Foster, D. M. and Ross, R.: Platelet-derived growth factor in vitro: Levels, activity, and rate of clearance. Blood, 64: 458-469 (1984).
8) Antoniades, H. N. and Scher, C. D.: Radioimmunoassay of a human serum growth factor for Balb-c-3T3 cells: Derivation from platelets. Proc. Natl. Acad. Sci. U.S.A., 74: 1973-1977 (1977).
3) Johnsson, A., Heldin, C. H., Wasteson, A., Westermark, B., Deuel, T. F., Huang, J. S., Seeburg, P. H., Gray, G., Ullrich, A., Scrace, G., Stroobant, P. and Waterfield, M. D.: The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J., 3: 921-928 (1984).
17) Levine, S. P. and Krentz, L. S.: Development of a radioimmunoassay for human platelet factor 4. Thromb. Res., 11: 673-686 (1977).
5) Kaplan, K. L., Broekman, M. J., Chernoff, A., Lesznik, G. R, and Drillings, M.: Platelet alphagranule proteins: Studies on release and subcellular localization. Blood, 53: 604-618 (1979).
18) Vogel, A., Raines, E., Kariya, B., Rivest, M. J. and Ross, R.: Coordinate control of 3T3 cell proliferation by platelet-derived growth factor and plasma components. Proc. Natl. Acad. Sci. U.S.A., 75: 2810-2814 (1978).
9) Ross, R., Glomset, J., Kariya, B. and Harker, L.: A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. U.S.A., 71: 1207-1210 (1974).
15) Huang, J. S., Huang, S. S. and Deuel, T. F.: Human platelet-derived growth factor: Radioimmunoassay and discovery of a specific plasma-binding protein. J. Cell. Biol., 97: 383-388 (1983).
2) Johnsson, A., Heldin, C. H., Westermark, B. and Wasteson, A.: Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem. Biophys. Res. Commun., 104: 66-74 (1982).
7) Kohler, N. and Lipton, A.: Platelets as a source of fibroblast growth-promoting activity. Exp. Cell. Res., 87: 297-301 (1974).
6) Gerrard, J. M., Phillips, D. R., Rao, G. H. R., Plow, E. F., Walz, D. A., Ross, R., Harker, L. A. and White, J. G.: Biochemical studies of two patients with the gray platelet syndrome. J. Clin. Invest., 66: 102-109 (1980).
19) Niman, H. and Houghten, R. A.: Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera. Science, 226: 701-703 (1984).
10) Ross, R. and Glomset, J. A.: The pathogenesis of atherosclerosis. N. Engl. J. Med., 295: 369-377, 420-425 (1976).
12) Bowen-Pope, D. F. and Ross, R.: Platelet-derived growth factor II. Specific binding to cultured cells. J. Biol. Chem., 257: 5161-5171 (1982).
4) Kaplan, D. R., Chao, F. C., Stiles, C. D., Antoniades, H. N. and Scher, C. D.: Platelet alphagranules contain a growth factor for fibroblasts. Blood, 53: 1043-1052 (1979).
11) Singh, J. P., Chaikin, M. A. and Stiles, C. D.: Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J. Cell. Biol., 95: 667-671 (1982).
14) Heldin, C. H., Westermark, B. and Wasteson, A.: Demonstration of an antibody against plateletderived growth factor. Exp. Cell. Res., 136: 255-261 (1981).
References_xml – reference: 3) Johnsson, A., Heldin, C. H., Wasteson, A., Westermark, B., Deuel, T. F., Huang, J. S., Seeburg, P. H., Gray, G., Ullrich, A., Scrace, G., Stroobant, P. and Waterfield, M. D.: The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J., 3: 921-928 (1984).
– reference: 4) Kaplan, D. R., Chao, F. C., Stiles, C. D., Antoniades, H. N. and Scher, C. D.: Platelet alphagranules contain a growth factor for fibroblasts. Blood, 53: 1043-1052 (1979).
– reference: 9) Ross, R., Glomset, J., Kariya, B. and Harker, L.: A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. U.S.A., 71: 1207-1210 (1974).
– reference: 7) Kohler, N. and Lipton, A.: Platelets as a source of fibroblast growth-promoting activity. Exp. Cell. Res., 87: 297-301 (1974).
– reference: 2) Johnsson, A., Heldin, C. H., Westermark, B. and Wasteson, A.: Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem. Biophys. Res. Commun., 104: 66-74 (1982).
– reference: 5) Kaplan, K. L., Broekman, M. J., Chernoff, A., Lesznik, G. R, and Drillings, M.: Platelet alphagranule proteins: Studies on release and subcellular localization. Blood, 53: 604-618 (1979).
– reference: 15) Huang, J. S., Huang, S. S. and Deuel, T. F.: Human platelet-derived growth factor: Radioimmunoassay and discovery of a specific plasma-binding protein. J. Cell. Biol., 97: 383-388 (1983).
– reference: 12) Bowen-Pope, D. F. and Ross, R.: Platelet-derived growth factor II. Specific binding to cultured cells. J. Biol. Chem., 257: 5161-5171 (1982).
– reference: 16) 杉原圭亮, 益子秀行, 山内忠一, 菅原敏行, 馬場正博: 合成ペプチドを免疫原とした単クローン性抗ヒトPDGF抗体の作成. 動脈硬化, 16: 37-39 (1988).
– reference: 19) Niman, H. and Houghten, R. A.: Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera. Science, 226: 701-703 (1984).
– reference: 8) Antoniades, H. N. and Scher, C. D.: Radioimmunoassay of a human serum growth factor for Balb-c-3T3 cells: Derivation from platelets. Proc. Natl. Acad. Sci. U.S.A., 74: 1973-1977 (1977).
– reference: 13) Bowen-Pope, D. F., Malpass, T. W., Foster, D. M. and Ross, R.: Platelet-derived growth factor in vitro: Levels, activity, and rate of clearance. Blood, 64: 458-469 (1984).
– reference: 1) Ross, R.: Platelet-derived growth factor. Ann. Rev. Med., 38: 71-79 (1987).
– reference: 10) Ross, R. and Glomset, J. A.: The pathogenesis of atherosclerosis. N. Engl. J. Med., 295: 369-377, 420-425 (1976).
– reference: 11) Singh, J. P., Chaikin, M. A. and Stiles, C. D.: Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J. Cell. Biol., 95: 667-671 (1982).
– reference: 6) Gerrard, J. M., Phillips, D. R., Rao, G. H. R., Plow, E. F., Walz, D. A., Ross, R., Harker, L. A. and White, J. G.: Biochemical studies of two patients with the gray platelet syndrome. J. Clin. Invest., 66: 102-109 (1980).
– reference: 18) Vogel, A., Raines, E., Kariya, B., Rivest, M. J. and Ross, R.: Coordinate control of 3T3 cell proliferation by platelet-derived growth factor and plasma components. Proc. Natl. Acad. Sci. U.S.A., 75: 2810-2814 (1978).
– reference: 14) Heldin, C. H., Westermark, B. and Wasteson, A.: Demonstration of an antibody against plateletderived growth factor. Exp. Cell. Res., 136: 255-261 (1981).
– reference: 17) Levine, S. P. and Krentz, L. S.: Development of a radioimmunoassay for human platelet factor 4. Thromb. Res., 11: 673-686 (1977).
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Title モノクローナル抗体を用いたヒト血小板由来成長因子のラジオイムノアッセイの基礎的検討およびその臨床応用
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