First-in-Human Studies of [ 18 F] Fluorohydroxyphenethylguanidines

• Published in: Circulation. Cardiovascular imaging Vol. 11; no. 12; p. e007965
• Main Authors: Raffel, David M, Jung, Yong-Woon, Koeppe, Robert A, Jang, Keun Sam, Gu, Guie, Scott, Peter J H, Murthy, Venkatesh L, Rothley, Jill, Frey, Kirk A
• Format: Journal Article
• Language: English
• Published: United States 01.12.2018
• Subjects: Adult; Female; Fluorine Radioisotopes; Guanidines - pharmacokinetics; Heart Conduction System - diagnostic imaging; Heart Conduction System - metabolism; Heart Failure - diagnosis; Heart Failure - metabolism; Humans; Male; Middle Aged; Phenethylamines - pharmacokinetics; Positron-Emission Tomography - methods; Sympathetic Nervous System - diagnostic imaging; Sympathetic Nervous System - metabolism; Tissue Distribution; Young Adult; heart failure; positron-emission tomography; sympathetic nervous system; defibrillator

Disease-induced damage to cardiac autonomic nerve populations is associated with an increased risk of sudden cardiac death. The extent of cardiac sympathetic denervation, assessed using planar scintigraphy or positron emission tomography, has been shown to predict the risk of arrhythmic events in he...