閉塞性動脈硬化症患者におけるL-カルニチン補充療法の検討
要旨：L-カルニチン投与（900 mg/day，3 カ月間）による閉塞性動脈硬化症患者の自覚症状や運動能への影響を検討した。33 名の検討において疾患特異性の高いVascuQOL 日本語版のactivity ドメインで投与前に比べ3 カ月目に有意差を持って改善が認められた。脈波，AI，6 分間最大歩行距離，WIQ でも改善傾向が認められた。カルニチンは運動能とともに動脈硬化自体も改善する可能性が示唆された。...
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| Published in | 脈管学 Vol. 55; no. 8; pp. 117 - 123 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本脈管学会
2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0387-1126 1880-8840 |
| DOI | 10.7133/jca.15-00004 |
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| Abstract | 要旨：L-カルニチン投与（900 mg/day，3 カ月間）による閉塞性動脈硬化症患者の自覚症状や運動能への影響を検討した。33 名の検討において疾患特異性の高いVascuQOL 日本語版のactivity ドメインで投与前に比べ3 カ月目に有意差を持って改善が認められた。脈波，AI，6 分間最大歩行距離，WIQ でも改善傾向が認められた。カルニチンは運動能とともに動脈硬化自体も改善する可能性が示唆された。 |
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| AbstractList | 要旨：L-カルニチン投与（900 mg/day，3 カ月間）による閉塞性動脈硬化症患者の自覚症状や運動能への影響を検討した。33 名の検討において疾患特異性の高いVascuQOL 日本語版のactivity ドメインで投与前に比べ3 カ月目に有意差を持って改善が認められた。脈波，AI，6 分間最大歩行距離，WIQ でも改善傾向が認められた。カルニチンは運動能とともに動脈硬化自体も改善する可能性が示唆された。 |
| Author | 洞口, 哲 加藤, 盛人 村上, 厚文 |
| Author_xml | – sequence: 1 fullname: 洞口, 哲 organization: 国際医療福祉大学病院循環器センター血管外科 – sequence: 1 fullname: 加藤, 盛人 organization: 国際医療福祉大学病院循環器センター血管外科 – sequence: 1 fullname: 村上, 厚文 organization: 国際医療福祉大学病院循環器センター血管外科 |
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| References | 13) 児玉浩子，清水俊明，瀧谷公隆，他：特殊ミルク，経腸栄養剤使用時のピットフォール．日本小児科学会誌2012; 116: 637–653 1) Brevetti G, Diehm C, Lambert D: European multicenter study on propionyl-L-carnitine in intermittent claudication. J Am Coll Cardiol 1999; 34: 1618–1624 5) 池田俊也，小林亜美，重松博，他：日本語版WIQ（歩行障害質問票）の開発．2005; 45: 233–240 10) Brevetti G, di Lisa F, Perna S, et al: Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. Circulation 1996; 93: 1685–1689 2) Hiatt WR, Regensteiner JG, Creager MA, et al: Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. Am J Med 2001; 110: 616–622 3) Norgren L, Hiatt WR, Dormandy JA, et al: Inter-society concensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 2007; 45: S1–S67 11) Nakajima Y, Ito T, Maeda Y, et al: Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics. Tohoku J Exp Med 2010; 221: 309–313 4) 南都伸介，飯田修：閉塞性動脈硬化症（PAD）診療の実践．PAD の病態生理―間欠性跛行を中心に，南江堂，東京，2009，1–5 9) Stephens FB, Constantin-Teodosiu D, Laithwaite D, et al: An Acute Increase in skeltal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. J Clin Endocrinol 2006; 91: 5013–5018 18) Brevetti G, Chiariello M, Ferulano G, et al: Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation 1988; 77: 767–773 6) 山口拓洋，宮田哲郎，市来正孝，他：VascuQOL の信頼性と妥当性の検討．脈管学 2011; 51: 347–358 15) Brevetti G, Perna S, Sabbà C, et al: Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. Eur Heart J 1992; 13: 251–255 7) Eguchi K, Murakami A, Horaguchi T, et al: Percutaneous transluminal angioplasty for peripheral artery disease confers cardiorenal protection. J Human Hypertens 2013; 37: 1–5 20) Higuchi T, Abe M, Yamazaki T, et al: Effects of levocarnitine on brachial-ankle pulse wave velocity in hemodialysis patients: a randomized controlled trial. Nutrients 2014; 6: 5992–6004 8) 高柳正樹：カルニチンの臨床．生物試料分析 2012; 35: 281–292 14) 田附裕子，曹英樹，上野豪久，他：中心静脈栄養施行患者におけるカルニチン補充の必要性の検討．静脈経腸栄養 2010; 25: 210 17) Brevetti G, Angelini C, Rosa M, et al: Muscle carnitine deficiency in patients with severe peripheral vascular disease. Circulation 1991; 84: 1490–1495 16) Hiatt WR, Wolffl EE, Regensteiner JG, et al: Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. Am J Physiol 1992; 73: 346–353 19) Goldenberg NA, Krantz MJ, Hiatt WR: L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. Vasc Med 2012; 17: 145–154 12) Matsuda I, Ohtani Y, Ninomiya N: Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy. J Pediatr 1986; 109: 131–134 |
| References_xml | – reference: 19) Goldenberg NA, Krantz MJ, Hiatt WR: L-Carnitine plus cilostazol versus cilostazol alone for the treatment of claudication in patients with peripheral artery disease: a multicenter, randomized, double-blind, placebo-controlled trial. Vasc Med 2012; 17: 145–154 – reference: 5) 池田俊也，小林亜美，重松博，他：日本語版WIQ（歩行障害質問票）の開発．2005; 45: 233–240 – reference: 16) Hiatt WR, Wolffl EE, Regensteiner JG, et al: Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. Am J Physiol 1992; 73: 346–353 – reference: 20) Higuchi T, Abe M, Yamazaki T, et al: Effects of levocarnitine on brachial-ankle pulse wave velocity in hemodialysis patients: a randomized controlled trial. Nutrients 2014; 6: 5992–6004 – reference: 6) 山口拓洋，宮田哲郎，市来正孝，他：VascuQOL の信頼性と妥当性の検討．脈管学 2011; 51: 347–358 – reference: 8) 高柳正樹：カルニチンの臨床．生物試料分析 2012; 35: 281–292 – reference: 17) Brevetti G, Angelini C, Rosa M, et al: Muscle carnitine deficiency in patients with severe peripheral vascular disease. Circulation 1991; 84: 1490–1495 – reference: 12) Matsuda I, Ohtani Y, Ninomiya N: Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy. J Pediatr 1986; 109: 131–134 – reference: 11) Nakajima Y, Ito T, Maeda Y, et al: Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics. Tohoku J Exp Med 2010; 221: 309–313 – reference: 1) Brevetti G, Diehm C, Lambert D: European multicenter study on propionyl-L-carnitine in intermittent claudication. J Am Coll Cardiol 1999; 34: 1618–1624 – reference: 15) Brevetti G, Perna S, Sabbà C, et al: Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. Eur Heart J 1992; 13: 251–255 – reference: 2) Hiatt WR, Regensteiner JG, Creager MA, et al: Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. Am J Med 2001; 110: 616–622 – reference: 7) Eguchi K, Murakami A, Horaguchi T, et al: Percutaneous transluminal angioplasty for peripheral artery disease confers cardiorenal protection. J Human Hypertens 2013; 37: 1–5 – reference: 10) Brevetti G, di Lisa F, Perna S, et al: Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. Circulation 1996; 93: 1685–1689 – reference: 3) Norgren L, Hiatt WR, Dormandy JA, et al: Inter-society concensus for the management of peripheral arterial disease (TASC II). J Vasc Surg 2007; 45: S1–S67 – reference: 14) 田附裕子，曹英樹，上野豪久，他：中心静脈栄養施行患者におけるカルニチン補充の必要性の検討．静脈経腸栄養 2010; 25: 210 – reference: 9) Stephens FB, Constantin-Teodosiu D, Laithwaite D, et al: An Acute Increase in skeltal muscle carnitine content alters fuel metabolism in resting human skeletal muscle. J Clin Endocrinol 2006; 91: 5013–5018 – reference: 13) 児玉浩子，清水俊明，瀧谷公隆，他：特殊ミルク，経腸栄養剤使用時のピットフォール．日本小児科学会誌2012; 116: 637–653 – reference: 18) Brevetti G, Chiariello M, Ferulano G, et al: Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation 1988; 77: 767–773 – reference: 4) 南都伸介，飯田修：閉塞性動脈硬化症（PAD）診療の実践．PAD の病態生理―間欠性跛行を中心に，南江堂，東京，2009，1–5 |
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| Title | 閉塞性動脈硬化症患者におけるL-カルニチン補充療法の検討 |
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